Kidney biopsy in the military hospital of morocco: complications and histopathological findings

Abstract

Epidemiological studies on renal biopsies are necessary to establish the pattern and trends of renal diseases in a particular geographic area. In this retrospective study, we reviewed the medical records, histopathology findings and complications of renal biopsy in a region of Morocco. We studied a total of 130 native kidney biopsies taken between January 2008 and January 2012. All biopsies were examined by light microscopy and immunofluorescence microscopy. There were 86 males (66.2%) and 44 females (33.8%), with a mean patient age of 44.82 ± 17.86 (range 8-86) years. The most common indications of renal biopsy was nephritic syndrome (61.5%), followed by renal failure of unknown etiology (30.8%) and asymptomatic urinary abnormalities (5.4%). Primary glomerulonephritis (PGN) was found in 60 (46.2%) of the patients. Among the PGN cases, the most common one was membranous nephropathy (MN) (12.3%). Secondary glomerular disease (SGN) accounted for 48 (36.9%) of the cases. The most common SGN was lupus nephritis (LN) (10%). Tubulointerstitial disease [13 (10%)] and vascular disease [9 (6.9%)] were less common. The most common complications of the procedure were pain at the biopsy site in 12.3%, gross hematuria in 12.3%, perirenal hematoma in 7.7% and hematuria requiring nephrectomy in 0.8% of the patients. The most common indication for renal biopsy was nephrotic syndrome, MN was the most frequent PGN and LN was the most frequent SGN in our report.

Results of native and transplant kidney biopsies of children in a single center over a 15 years period

“…In 1951, Inverson and Brun reported the first large series of needle biopsies of the kidney [1]. Although a renal biopsy is difficult in children because of variable sizes of kidneys and different levels of cooperation, especially with the possibility of ultrasound-guided biopsy enhanced with the latest technologies, clinicians can make a choice about biopsies undoubtedly [2].…”

A Systematic Review of Complications Associated With Percutaneous Native Kidney Biopsies in Adults in Low- and Middle-Income Countries

“…Thirty-nine articles 4,8,[15][16][17] were eligible for data extraction, reporting on 19,500 kidney biopsies performed on 19,338 patients in 18 countries located in six regions of the world (Figure 1 -Prisma flow chart). These regions include Sub-J o u r n a l P r e -p r o o f Saharan Africa (5 studies); 24,[27][28][29]52 South Asia (15 studies); 15,22,23,[30][31][32][33][34][35][36][37][38][39]54,55 Middle East and North Africa (7 studies); 8,17,25,26,[40][41][42] Latin America and Caribbean (2 studies); 50,51 Europe and Central Asia (3 studies); 48,49,53 and East Asia and Pacific (7 studies). 4,16,[44][45][46][47]56 There were 5 studies from low-income countries 15,[22][23]…”

“…1,3 Although some studies have shown that PNKB is a safe procedure and frequently showing significant complication to occur in under 1%, 4,5 higher rates of kidney biopsy-related complications have been reported from other studies. [6][7][8] In a single centre study of 1,055 adults from the U.S., major complications occurred in 6.6% of biopsies, transfusions required in 5.3% and only 1 death (0.09%) resulted following PNKB bleeding. 7 However, a 5-year nationwide study in the U.S.…”

Incidence of major complications after percutaneous native renal biopsies in adults from low-income to middle-income countries: a protocol for systematic review and meta-analysis

“… 3 However, much higher rates have been reported in other parts of the world. 4–6 In Morocco, 12.3% of patients who had undergone a percutaneous native kidney biopsy had gross haematuria and 0.8% required nephrectomy after biopsy. 4 On the other hand, a systematic review with studies mainly from high-income countries found that only 0.9% of 9474 renal biopsies required red blood cell transfusion.…”

“… 4–6 In Morocco, 12.3% of patients who had undergone a percutaneous native kidney biopsy had gross haematuria and 0.8% required nephrectomy after biopsy. 4 On the other hand, a systematic review with studies mainly from high-income countries found that only 0.9% of 9474 renal biopsies required red blood cell transfusion. 7 However, the review only included studies if renal biopsy was performed by real-time ultrasound using automatic biopsy needles.…”