Kidney cancer. Heavy metals as a risk factor

Sá, Isabel; Semedo, M.; Cunha, Mónica Elisabete

doi:10.1016/j.pbj.2016.03.006

Cited by 32 publications

(11 citation statements)

References 18 publications

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“…However, in our study, no findings related to liver cancer were encountered. Literature information has shown that heavy metals can cause cancer (Sá et al, 2016), but our study suggests that there is no cancer in the liver and that mussels are fed to rats for a short time, such as 30 days. Rats fed with mussels for a longer period may think that cancer may occur in the liver tissue.…”

Section: Heavy Metal Analysis Resultscontrasting

confidence: 58%

Effect of Mediterranean Mussels (Mytilus galloprovincialis) From Polluted Areas on Hepatotoicity in Rats by Immunuhistochemical Method

Çakına

İrkin

Özdemir³

et al. 2021

Acta Aquatica Turcica

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Mussels (Mytilus galloprovincialis) are aquatic organisms that can accumulate all the factors that pollute the fresh and saltwater environment. Although the Dardanelles has been exposed to environmental pollution for many years, it is also an important region for crustaceans. We aimed to investigate the histopathological changes in the liver parenchyma which is an important gland of the digestive system by feeding these mussels to rats. Twenty-four male Wistar albino were used in the study. The first group (control): fed with standard rat feed, the second group (experiment 1): 4/5 mussel + 1/5 standard rat feed daily; third group (experiment 2): 4/5 mussel + 1/5 standard rat feed every other day, the fourth group (experiment 3): groups were formed with 4/5 mussel + 1/5 standard rat feed every three days. All liver tissue samples taken from the experimental and control groups were stained with hematoxylin-eosin, and immuohitochemically staining inflammatory marker TNF-α and NF-κB after routine histopathological follow-up and analyzed with a light microscope image analysis system. It was observed that mononuclear cells caused inflammation of portal areas, increased sinusoidal dilatation and congestion and degeneration due to vacuolization in hepatocytes in the liver parenchyma of mussel-fed rats. Besides, immunohistochemical staining, TNF-α, and NF-κB immunoreactivity were observed in the liver cells of especially in the second group of rats. As a result, it has been shown that the consumption of mussels obtained and marketed without considering environmental pollution may trigger important digestive system organs of liver diseases.

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Section: Heavy Metal Analysis Resultscontrasting

confidence: 58%

Effect of Mediterranean Mussels (Mytilus galloprovincialis) From Polluted Areas on Hepatotoicity in Rats by Immunuhistochemical Method

Çakına

İrkin

Özdemir³

et al. 2021

Acta Aquatica Turcica

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“…Iron is a key component of red blood cells and also plays a crucial role in gene expression [ 20 ]. On the contrary, Pb and Cd are teratogenic [ 21 , 22 ], while micronutrients once consumed in amounts beyond the international recommended levels may also lead to severe health effects.…”

Section: Introductionmentioning

confidence: 99%

Food Safety Analysis of Milk and Beef in Southwestern Uganda

Kasozi

Natabo

Namubiru

et al. 2018

Journal of Environmental and Public Health

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Background Inorganic pollutants in milk and beef are of major public health concern; however, information in Africa is still limited due to low food safety monitoring practices. In this study, we established levels of lead (Pb), zinc (Zn), cadmium (Cd), copper (Cu), and iron (Fe) in milk and beef and obtained the estimated daily intake (EDI) and incremental lifetime cancer risk (ILCR) as measures of risk to the Ugandan population. Materials and Methods This was a cross-sectional study in which a total of 40 samples of milk and beef were collected from Bushenyi district in southwestern Uganda. Samples were analyzed by atomic absorbance spectrophotometer, and the EDI and ILCR were computed using the US EPA reference values. Results and Discussion Heavy metal concentrations were highest in the order of Zn > Fe > Pb > Cu in milk samples, while in beef samples, concentrations were highest in the order of Zn > Pb > Fe > Cu and no Cd was detected. Furthermore, beef had significantly higher (P < 0.05) Pb and Fe concentrations than milk. The EDI was highest in children, and this was followed by very high ILCR levels, showing that milk and beef are not safe for children in Uganda. Bearing in mind that a high HI was shown, beef and milk from these regions are not recommended for consumption especially by children although more studies remain to be conducted. Conclusion Heavy metals in milk and beef of Uganda may predispose the indigenous community to cancer and other health-related illnesses, showing a need for improved food safety screening to promote food safety.

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“…Some specific biological functions need the presence of these elements in the syntheses of proteins to exercise their functions, like Zn and Cu, which take part as co-factors of enzymes or directly take part in several reactions in the body, and are considered essential. [2][3][4][5][6][7] *marianebutik@gmail.com…”

Section: Introductionmentioning

confidence: 99%

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Animal Tissues Using Logistic Regression

Butik¹,

Filho²,

Maciel³

et al. 2020

Rev. Virtual Quim.

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Essential metals are important in the normal functioning of the body. However, tissues or organs can be affected when there are inappropriate concentrations of these elements. In the literature, there are works indicating that essential elements may be related to the emergence of neoplasms. Therefore, it is important to determine the metal species in biological samples in order to relate the concentration of these species to the emergence of neoplasms. This study reports the application of the Flame Atomic Absorption Spectroscopy (FAAS) for the quantification of Cu, Fe, Mn and Zn in 31 samples of canine tissue (11 of mammary glands, 4 of pancreas, 3 of skin and 13 of testicles) with and without neoplasms, using alkaline solubilization as sample preparation method. The concentration of these metals was used as co-variables for the construction of models of logistic regression. The concentration of Zn in breast and Fe in pancreas was significant (p < 0.05) in the logistic models. The findings of this study describe that the elements Fe and Zn play a major role in the carcinomas development, since high levels of these metals were observed in neoplastic tissues.

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Kidney cancer. Heavy metals as a risk factor

Cited by 32 publications

References 18 publications

Effect of Mediterranean Mussels (Mytilus galloprovincialis) From Polluted Areas on Hepatotoicity in Rats by Immunuhistochemical Method

Effect of Mediterranean Mussels (Mytilus galloprovincialis) From Polluted Areas on Hepatotoicity in Rats by Immunuhistochemical Method

Food Safety Analysis of Milk and Beef in Southwestern Uganda

Comparative Trace Elemental Analysis in Cancerous and Noncancerous Animal Tissues Using Logistic Regression

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