Kidney complications in 107 Fanconi anemia patients submitted to hematopoietic cell transplantation

Cunha, Mariana Munhoz da; Barreto, Fellype Carvalho; Nichele, Samantha; Trennepohl, Joanna; Ribeiro, Lisandro; Loth, Gisele; Koliski, Adriana; Jardim, Tyane de Almeida Pinto; Mello, Adriana Lima; Pasqüini, Ricardo; Sylvestre, Lucimary de Castro; Bonfim, Carmem

doi:10.1007/s00431-021-04263-0

Cited by 5 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, stage at least 2 AKI with an eGFR at least 60 ml/min/1.73 m 2 or duration less than 28 days was not associated with long-term CKD development. The association of severe -but not mild -AKI with worsening kidney function over time in children who undergo HSCT due to malignant or nonmalignant disease is in line with observations by other research groups [90,91].…”

Section: Paediatric Oncology Haematopoietic Stem Cell Transplantation...supporting

confidence: 89%

Long-term outcomes of acute kidney injury in children

Schuermans

Eynde

Mekahli

et al. 2022

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of reviewAcute kidney injury (AKI) affects up to 35% of all critically ill children and is associated with substantial short-term morbidity and mortality. However, the link between paediatric AKI and long-term adverse outcomes remains incompletely understood. This review highlights the most recent clinical data supporting the role of paediatric AKI as a risk factor for long-term kidney and cardiovascular consequences. In addition, it stresses the need for long-term surveillance of paediatric AKI survivors.Recent findingsRecent large-scale studies have led to an increasing understanding that paediatric AKI is a significant risk factor for adverse outcomes such as hypertension, cardiovascular disease and chronic kidney disease (CKD) over time. These long-term sequelae of paediatric AKI are most often observed in vulnerable populations, such as critically ill children, paediatric cardiac surgery patients, children who suffer from severe infections and paediatric cancer patients.SummaryA growing body of research has shown that paediatric AKI is associated with long-term adverse outcomes such as CKD, hypertension and cardiovascular disease. Although therapeutic pathways tailored to individual paediatric AKI patients are yet to be validated, we provide a framework to guide monitoring and prevention in children at the highest risk for developing long-term kidney dysfunction.

show abstract

Section: Paediatric Oncology Haematopoietic Stem Cell Transplantation...supporting

confidence: 89%

Long-term outcomes of acute kidney injury in children

Schuermans

Eynde

Mekahli

et al. 2022

Current Opinion in Pediatrics

View full text Add to dashboard Cite

show abstract

“…1). Among included studies, four were prospective and 16 were retrospective [10,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. A total of 4,378 patients who underwent HSCT were included in the 20 studies, including 2,219 and 2,159 patients with and without AKI, respectively.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Acute Kidney Injury after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis

Cui,

Zhang,

2023

Blood Purif

View full text Add to dashboard Cite

Aims: The aim of this study was to identify risk factors associated with acute kidney injury (AKI) after hematopoietic stem cell transplantation (HSCT) by systematically reviewing the relevant literature. Methods: This meta-analysis surveyed relevant articles published in PubMed, Embase, and the Cochrane Library up to December 2022 to identify the reliable risk factors for AKI after HSCT, calculating odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results: Twenty studies with 4,378 patients were included. Umbilical cord blood transplantation (OR = 2.36; 95% CI: 1.77–3.15; p < 0.00001), calcineurin inhibitors (CNIs) (OR = 1.97; 95% CI: 1.06–3.67; p = 0.03), sinusoidal obstruction syndrome (SOS) (OR = 5.80; 95% CI: 3.96–8.51; p < 0.00001), allogeneic transplantation (OR = 4.27; 95% CI: 1.83–9.95; p = 0.0008), hypertension (OR = 2.07; 95% CI: 1.16–3.69; p = 0.01), amphotericin B (OR = 4.03; 95% CI: 2.54–6.40; p < 0.00001), vancomycin (OR = 2.19; 95% CI: 1.24–3.87; p = 0.007), and total body irradiation (TBI) (OR = 1.81; 95% CI: 1.27–2.57; p = 0.001) were risk factors for AKI. Conclusion: Umbilical cord blood transplantation, CNIs, SOS, allogeneic transplantation, hypertension, amphotericin B, vancomycin, and TBI were risk factors for AKI. It is important for clinical staff to be aware of these risk factors in their treatment planning with patients undergoing HSCT.

show abstract

“…This highlights the importance of renal evaluation when FA is suspected. The spectrum of urinary anomalies is heterogenous; it includes renal hypoplasia or aplasia, dysplastic or ectopic kidneys, crossed fused ectopia of kidneys, double ureters, cysts, and horseshoe kidney ( 224 , 228 ). These renal anomalies can frequently be accompanied by urinary tract infections, which are key indicators of a renal malformation particularly if present frequently and in early childhood ( 224 ).…”

Section: Dysmorphological and Oncological Phenotype Of Patients With ...mentioning

confidence: 99%

Fanconi anemia and dyskeratosis congenita/telomere biology disorders: Two inherited bone marrow failure syndromes with genomic instability

et al. 2022

View full text Add to dashboard Cite

Inherited bone marrow failure syndromes (IBMFS) are a complex and heterogeneous group of genetic diseases. To date, at least 13 IBMFS have been characterized. Their pathophysiology is associated with germline pathogenic variants in genes that affect hematopoiesis. A couple of these diseases also have genomic instability, Fanconi anemia due to DNA damage repair deficiency and dyskeratosis congenita/telomere biology disorders as a result of an alteration in telomere maintenance. Patients can have extramedullary manifestations, including cancer and functional or structural physical abnormalities. Furthermore, the phenotypic spectrum varies from cryptic features to patients with significantly evident manifestations. These diseases require a high index of suspicion and should be considered in any patient with abnormal hematopoiesis, even if extramedullary manifestations are not evident. This review describes the disrupted cellular processes that lead to the affected maintenance of the genome structure, contrasting the dysmorphological and oncological phenotypes of Fanconi anemia and dyskeratosis congenita/telomere biology disorders. Through a dysmorphological analysis, we describe the phenotypic features that allow to make the differential diagnosis and the early identification of patients, even before the onset of hematological or oncological manifestations. From the oncological perspective, we analyzed the spectrum and risks of cancers in patients and carriers.

show abstract

Kidney complications in 107 Fanconi anemia patients submitted to hematopoietic cell transplantation

Cited by 5 publications

References 43 publications

Long-term outcomes of acute kidney injury in children

Long-term outcomes of acute kidney injury in children

Risk Factors for Acute Kidney Injury after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis

Fanconi anemia and dyskeratosis congenita/telomere biology disorders: Two inherited bone marrow failure syndromes with genomic instability

Contact Info

Product

Resources

About