Kidney Function After the First Kidney Stone Event

Abstract

Objective To determine if there is a persistent decline in kidney function after the first kidney stone event. Patient and Methods Incident symptomatic stone formers and age- and sex-matched controls underwent 2 study visits 90 days apart to assess kidney function, complete a survey, and have their medical records reviewed. Kidney function was compared between stone formers and controls adjusting for clinical, blood, and urine risk factors. Results There were 384 stone formers and 457 controls. At visit 1, a median of 104 days after the stone event, stone formers compared with controls had similar serum creatinine (0.86 vs 0.84 mg/dL; P=.23), higher serum cystatin C (0.83 vs 0.72 mg/L; P<.001), higher urine protein (34.2 vs 19.7 mg/24 h; P<.001) levels, and were more likely to have albuminuria (24 h urine albumin >30 mg: 5.4% vs 2.2%; P=.02). Findings were similar after adjustment for risk factors and at visit 2, a median of 92 days after visit 1. In the 173 stone formers with serum creatinine levels from care before study participation, the mean serum creatinine level was 0.84 mg/dL before the stone event, increased to 0.97 mg/dL (P<.001) at the stone event, but returned to 0.85 mg/dL (P=.38) after the stone event (visit 1). Conclusions Incident symptomatic stone formers have a rise in serum creatinine levels that resolves. However, stone formers have sustained higher cystatin C levels and proteinuria that may affect long-term risk of chronic kidney disease.

Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones

“…Indeed, other recent publications demonstrated a correlation between dpucMGP and kidney function, leading to the hypotheses that kidney disease may lead to vitamin K deficiency or conversely, that vitamin K deficiency is a risk factor of kidney damage [24,25]. As shown previously, stone formers have an increased cystatin C levels that may be associated with the risk of chronic kidney disease [12]. While no study has directly reported an association between vitamin K status and urolithiasis, it is well-known that higher vegetables intake decrease the risk of urolithiasis [26].…”

“…The lower limit of quantification was 300 pmol/L and the upper reference range 521 pmol/L (CI 513-550 pmol/L). The other laboratory parameters were previously assessed at the Mayo Clinic in Minnesota (USA) as previously described [12]. Serum creatinine was measured by standardized isotope dilution mass spectrometry traceable enzymatic assay (Roche), and serum cystatin C by particle-enhanced turbidimetric assay (Gentian AS).…”

“…We studied 498 incident (first-time) symptomatic kidney stone-formers and 395 matched non-stone formers who had a baseline study visit to collect and bank serum at Mayo Clinic in Minnesota and Florida (USA), as previously described [12]. Symptomatic stone events required both the presence of symptoms (pain or gross hematuria) and a confirmed stone (obstructing the ureter on imaging or a voided stone) in the medical records.…”

Hubungan proteinuria dan batu saluran kemih: studi analitik

“…Hasil ini tidak berubah setelah dilakukan followup 3 bulan oleh peneliti. 4 Bergsland dkk dari University of Chicago menemukan bahwa marker protein urin dapat membedakan individu dengan risiko stone former dan non stone former. Mereka melakukan analisa elektroforesis protein urin dan berkesimpulan bahwa inter-a-trypsin inhibitor (ITI), prothrombin fragment 1 (PF1), CD59, dan calgranulin B (calB) berhubungan dengan angka kejadian dan rekurensi batu saluran kemih.…”

The mechanism of the preventive effect of Shen’an capsule on the calcium oxalate crystal‐induced early renal injury based on metabolomics

“…The prevalence of kidney stone disease is ~10% worldwide (Scales, Smith, Hanley, & Saigal, ; Wang et al, ) and is progressively increasing owing to various factors, including metabolic abnormalities caused by diet and environment (Morgan & Pearle, ). Increased incidences of acute or chronic kidney injury (Sigurjonsdottir, Runolfsdottir, Indridason, Palsson, & Edvardsson, ) resulting from renal dysfunction owing to kidney stones could jeopardize public health (Haley et al, ). In addition, nephrolithiasis has been recognized as a systemic disorder (Shadman & Bastani, ), which is associated with the development of diverse cardiovascular diseases (Alexander et al, ).…”