Kidney injury molecule-1, a sensitive and specific marker for identifying acute proximal tubular injury, can be used to predict renal functional recovery in native renal biopsies

Yin, Wenqing; Kumar, T.; Lai, Zongshan; Xu, Zhiyong; Kanaan, Hassan; Li, Wei; Zhang, Ping L.

doi:10.1007/s11255-019-02311-1

Cited by 19 publications

(10 citation statements)

References 27 publications

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“…KIM1 protects the kidney from acute injury by down-regulating inflammation and mediating phagocytosis of apoptotic cellular debris [ 76 ]. KIM1 is up-regulated in various primary and secondary kidney diseases, and can be used as a marker for renal proximal tubule damage [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Common physiologic and proteomic biomarkers in pulmonary and coronary artery disease

et al. 2022

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Objective Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are leading causes of global morbidity and mortality. There is a well-known comorbidity between COPD and CAD, which is only partly explained by smoking and other known common risk factors. In order to better understand the relationship between COPD and CAD, we analyzed myocardial perfusion, pulmonary function and novel cardiovascular biomarkers in patients with symptoms suggesting myocardial ischemia. Methods A total of 396 subjects from the Swedish Biomarkers and Genetics CardioPulmonary Physiology Study (BiG CaPPS) were included, all of whom had been referred to myocardial perfusion imaging due to suspected myocardial ischemia. Subjects performed myocardial perfusion imaging (MPI), pulmonary function tests (PFT) and analysis of 92 proteomic biomarkers, previously associated with cardiovascular disease. Linear regression was used to study the relationship between MPI and PFT results and proteomic biomarkers. Results Subjects with CAD (n = 159) had lower diffusing capacity (DLCO) than patients without CAD (6.64 versus 7.17 mmol/(min*kPa*l); p = 0.004) in models adjusted for common covariates such as smoking, but also diabetes and brain natriuretic peptide (BNP). The association remained significant after additional adjustment for forced expiratory volume in one second (FEV1) (p = 0.009). Subjects with CAD, compared with subjects without CAD, had higher total airway resistance (0.37 vs 0.36 kPa/(l/s); p = 0.036). Among 92 protein biomarkers, nine were associated with a combined diagnosis of CAD and airflow obstruction: VSIG2, KIM1, FGF-23, REN, XCL1, GIF, ADM, TRAIL-R2 and PRSS8. Significance Diffusing capacity for carbon monoxide is decreased in patients with CAD, independently of decreased FEV1, diabetes, and elevated BNP. Several cardiovascular biomarkers are associated with co-existent CAD and airflow obstruction, but none with airflow obstruction only. The current findings indicate that the interaction between CAD and lung function is complex, including mechanisms beyond the known association between CAD and reduced ventilation.

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Section: Discussionmentioning

confidence: 99%

Common physiologic and proteomic biomarkers in pulmonary and coronary artery disease

et al. 2022

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“…Thus, a1-AGP decreases of TNF-a and IL-6 in the serum may be resultant of downregulated KIM-1 levels in the blood. Moreover, KIM-1 is mainly expressed in differentiated proximal tubular epithelial cells, and its kidney expression is significantly elevated in patients with acute renal tubular injury (42). KIM-1 plays a role in the removal of apoptotic cells and necrotic tissue fragments (41,43,44).…”

Section: Discussionmentioning

confidence: 99%

The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury

Long

Wang³

et al. 2021

Shock

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Background: Crush syndrome (CS) is the most common cause of deaths following earthquakes and other disasters. The pathogenesis of CS has yet to be fully elucidated. Thus, clinical choice of ideal drug treatments for CS remains deficient. Methods and Results: In this study, we first evaluated the relation between extrusion force and the severities of CS. Rats were exposed to different extrusion forces: 1 kg, 3 kg, 5 kg, and 8 kg, respectively. Survival rates, crushed muscle tissue edema, serum biochemical parameters, and histopathological staining were used to assess severity. Our results showed that there were no statistical differences in survival rate or changes in thigh circumference among the different extrusion forces groups. However, serum levels of potassium, creatine kinase, blood urea nitrogen, creatinine, and myoglobin were elevated at 12-and 24-h post-decompression in 5 kg and 8 kg groups, compared with 1 kg and 3 kg groups. Histopathological staining demonstrated that the degree of organ damage to kidney, muscle, and lung tissues correlated with increasing extrusion force. We next analyzed changes in serum protein profiles in 3 kg or 5 kg extrusion pressure groups. A total of 76 proteins (20 upregulated, 56 downregulated) were found to be altered at all three time points (0, 12, and 72 h) post-decompression, compared with the control group. Three common upregulated proteins alpha-1-acid glycoprotein (a1-AGP), neutrophil gelatinase-associated lipocalin (NGAL), and Haptoglobin were selected for validation of increased expression. a1-AGP was explored as a treatment for CS-induced acute kidney injury (AKI). Intraperitoneal injection of a1-AGP protected kidneys from CS-induced AKI by regulating TNF-a and IL-6 production, attenuating neutrophil recruitment, and reducing renal cell apoptosis. Conclusion: Our findings demonstrated that the severity of crush injury is causally related to extrusion pressure and increase in blood serum markers. Our identification of the biomarker and treatment candidate, a1-AGP, suggests its implication in predicting the severity of CS and its use as a mediator of CSinduced AKI, respectively.

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“…KIM-1, which is known to increase kidney damage, can be used as a sensitive marker for the identi cation of acute tubular damage, especially in proximal tubules [35]. In the results of KIM-1 expression, a statistically signi cant increase was observed in Exercise group compared to all other groups, and in Exercise+BCAA group compared to only BCAA group.…”

Section: Discussionmentioning

confidence: 94%

The Effects of Branched Chain Amino Acid Supplement on Kidney Tissue of Exercising Rats

Aydeğer¹,

Eroğlu²

2021

Preprint

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One of the supplements used in with exercise programs is branched chain amino acids (BCAAs) which preferred because of their effect on novation of muscle protein synthesis. However, BCAAs increase their amount in the blood in a short time due to their properties. In this case, the result can increase the workload of the kidneys. Based on the information, this study investigated the effects of resistance exercise and BCAA supplements on kidney tissue. A total of 24 Wistar Albino male rats were divided equally into 4 groups: Control, BCAA, Exercise and Exercise+BCAA. In six-week study, resistance swimming exercise was applied to exercise groups. BCAA groups were given BCAA supplements at doses of 2.5 mg/kg before exercise. End of the study, histological, immunochemical, and RT-PCR analyses were performed. As a result of the findings obtained, it was found that use of BCAA supplements together with exercise caused tubular necrosis (p=0.002). A significant increase was found in caspase 3 IHC staining findings in BCAA and Exercise+BCAA groups compared to Control group (p=0.011; p=0.02). Also, KIM-1 expression levels were higher in Exercise group compared to all other groups (p=0.004; p=0.003; p=0.008). As a result, BCAA consumption in combination with resistant exercise caused damage to kidney tissue.

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Kidney injury molecule-1, a sensitive and specific marker for identifying acute proximal tubular injury, can be used to predict renal functional recovery in native renal biopsies

Cited by 19 publications

References 27 publications

Common physiologic and proteomic biomarkers in pulmonary and coronary artery disease

Common physiologic and proteomic biomarkers in pulmonary and coronary artery disease

The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury

The Effects of Branched Chain Amino Acid Supplement on Kidney Tissue of Exercising Rats

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