Kidney injury molecule‑1 levels are associated with therapeutic outcomes and renal tubulointerstitial injury severity in idiopathic membranous nephropathy

Abstract

Kidney injury molecule-1 (KIM-1) has an important role in chronic kidney disease development. The present study aimed to retrospectively analyze patients with idiopathic membranous nephrology (IMN) with different therapeutic outcomes to investigate the association between KIM-1 levels and therapeutic outcomes. A total of 51 patients with IMN and 20 healthy controls were included. Patients were classified into three groups: Spontaneous remission, remission with immunosuppressive therapy (IST) and nonremission with IST. Clinical and biochemical variables were collected. Urinary KIM-1 levels were measured by ELISA and renal KIM-1 expression was evaluated by immunohistochemistry. Patients with IMN were characterized as having elevated urinary and renal KIM-1 levels compared with those in the controls. Significantly increased urinary and renal KIM-1 levels were observed in the nonremission with IST group compared with those in the spontaneous remission group, and the same trend was observed for the plasma anti-podocyte antigen phospholipase A2 receptor antibody levels. Patients with more severe tubular injury (T2 index) presented with significantly higher urinary and renal KIM-1 levels than those with the T0 index. Urinary and renal KIM-1 levels were positively correlated with blood urea nitrogen, serum creatinine, serum cystatin-C, urinary albumin/creatinine ratio, urinary β2-microglobulin and the renal interstitial fibrosis index, and they were negatively correlated with serum albumin. Furthermore, urinary KIM-1 levels were positively correlated with the renal KIM-1 levels. In conclusion, the measurement of urinary and renal KIM-1 levels may be helpful in guiding medication selection and predicting therapeutic outcomes for patients with IMN.

Glomerulus-Targeted ROS-Responsive Polymeric Nanoparticles for Effective Membranous Nephropathy Therapy

“…Again, PPS-CPNs/CLT reduced these tubular lesions more effectively than other formulations. Kidney injury molecule-1 (KIM-1) is a transmembrane protein that is abundantly expressed only in damaged proximal tubular epithelial cells . It has been identified as a sensitive diagnostic indicator for various kidney diseases, including MN in clinical settings.…”

“…Kidney injury molecule-1 (KIM-1) is a transmembrane protein that is abundantly expressed only in damaged proximal tubular epithelial cells. 48 It has been identified as a sensitive diagnostic indicator for various kidney diseases, including MN in clinical settings. Here, we also investigated the impact of CLT formulation on the expression of KIM-1 in proximal tubular epithelial cells of PHN rats.…”

Lesión Renal Aguda y Cuidados Críticos: Avances en la Detección Temprana.

“…Inhibidor tisular de metaloproteinasas-2 (TIMP-2) y su proteína de unión al factor de crecimiento de insulina 7 (IGFBP7), interleucina (IL 18) son opciones de biomarcadores para predecir lesión renal aguda en la unidad de cuidados intensivos (15)(16)(17).…”