Kidney oxygenation during water diuresis and endothelial function in patients with type 2 diabetes and subjects at risk to develop diabetes

Economides, Panayiotis A.; Caselli, Antonella; Chen, Zuo; Sparks, Caitlin; Khaodhiar, Lalita; Katsilambros, Nicholas; Horton, Edward S.; Veves, Aristidis

doi:10.1016/j.metabol.2003.09.019

Cited by 35 publications

(26 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in subjects with early type 2 diabetic nephropathy (n=38), studied by Economides et al, 34 baseline BOLD MRI showed no difference in cortical or medullary oxygenation compared with historical controls. Cortical but not medullary oxygenation correlated with glycemic control.…”

Section: Neugarten and Golestanehmentioning

confidence: 85%

“…33 Similarly, other investigators have demonstrated that water diuresis failed to improve medullary oxygenation in early type 2 diabetic nephropathy and in healthy subjects at risk for diabetes mellitus, although cortical oxygenation increased slightly. 34 …”

Section: Water Diuresismentioning

confidence: 99%

“…53 After longer periods of reperfusion in the rat (3 days), medullary oxygenation was increased despite a reduction in medullary blood flow, with no change in cortical pO 2 . 54 Hyperoxia after ischemia/ reperfusion injury may be explained if reduced oxygen consumption due to reduced Cortex Epstein et al 33 Wang et al 50 Economides et al 34 Pruijm et al 26 …”

Section: Acute Kidney Injury Ischemia Reperfusion Injurymentioning

confidence: 99%

See 2 more Smart Citations

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

View full text Add to dashboard Cite

Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to investigate the role of hypoxia in the pathogenesis of acute kidney injury and progressive chronic kidney disease, numerous technical limitations confound interpretation of data derived from this approach. BOLD MRI has been utilized to assess intrarenal oxygenation in numerous experimental models of kidney disease and in human subjects with diabetic and nondiabetic chronic kidney disease, acute kidney injury, renal allograft rejection, contrast-associated nephropathy, and obstructive uropathy. However, confidence in conclusions based on data derived from BOLD MRI measurements will require continuing advances and technical refinements in the use of this technique.

show abstract

Section: Neugarten and Golestanehmentioning

confidence: 85%

Section: Water Diuresismentioning

confidence: 99%

Section: Acute Kidney Injury Ischemia Reperfusion Injurymentioning

confidence: 99%

See 1 more Smart Citation

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

View full text Add to dashboard Cite

show abstract

“…15,16,148,[152][153][154] Hypercholesterolemia High cholesterol levels have been shown to correlate with reduced renal oxygenation and increased kidney damage in response to ischemia. [155][156][157] One mechanism by which cholesterol likely drives these processes is through its role in determining the physical properties of the cell surface. Cholesterol constitutes the non-polar, hydrophobic lipid of the enveloping layer of the erythrocyte membrane.…”

Section: Hypertensionmentioning

confidence: 99%

Hypoxia: The Force that Drives Chronic Kidney Disease

Colgan

Shelley

2016

Clinical Medicine & Research

128

111

View full text Add to dashboard Cite

In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the elderly are disproportionally high. Consequently, as life expectancy increases and the baby-boom generation reaches retirement age, the already heavy burden imposed by ESRD on the US health care system is set to increase dramatically. ESRD represents the terminal stage of chronic kidney disease (CKD). A large body of evidence indicating that CKD is driven by renal tissue hypoxia has led to the development of therapeutic strategies that increase kidney oxygenation and the contention that chronic hypoxia is the final common pathway to end-stage renal failure. Numerous studies have demonstrated that one of the most potent means by which hypoxic conditions within the kidney produce CKD is by inducing a sustained inflammatory attack by infiltrating leukocytes. Indispensable to this attack is the acquisition by leukocytes of an adhesive phenotype. It was thought that this process resulted exclusively from leukocytes responding to cytokines released from ischemic renal endothelium. However, recently it has been demonstrated that leukocytes also become activated independent of the hypoxic response of endothelial cells. It was found that this endothelium-independent mechanism involves leukocytes directly sensing hypoxia and responding by transcriptional induction of the genes that encode the β2-integrin family of adhesion molecules. This induction likely maintains the long-term inflammation by which hypoxia drives the pathogenesis of CKD. Consequently, targeting these transcriptional mechanisms would appear to represent a promising new therapeutic strategy.

show abstract

“…These methods have been translated from brain imaging studies that employ changes in tissue R 2 * to report on neural activity via blood oxygenation [13]. Applied to renal tissue, studies have suggested that changes in cortical and medullary oxygenation can be monitored via R 2 * mapping, and that tissue oxygenation change in response to physiological perturbations (including water loading) can differ between normal and disease states [14][15][16][17][18][19], including type 2 diabetes [20,21].…”

Section: Introductionmentioning

confidence: 99%