2004
DOI: 10.1097/01.asn.0000127865.26968.36
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Kidney Protein Dynamics and Ammoniagenesis in Humans with Chronic Metabolic Acidosis

Abstract: Abstract. To evaluate the effects of chronic metabolic acidosis on protein dynamics and amino acid oxidation in the human kidney, a combination of organ isotopic ( 14 C-leucine) and mass-balance techniques in 11 subjects with normal renal function undergoing venous catheterizations was used. Five of 11 studies were performed in the presence of metabolic acidosis. In subjects with normal acid-base balance, kidney protein degradation was 35% to 130% higher than protein synthesis, so net protein leucine balance w… Show more

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Cited by 35 publications
(17 citation statements)
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“…The kidneys play an important role in correcting acidosis by enhanced production or excretion of ammonia. A large acid load initiates ammonia excretion while a basic load initiates ammonia production (Garibotto et al, 2004). Human rhesus (Rh) proteins expressed in erythroid cells and epithelial tissues have been described as ammonia transporters.…”
Section: The Role Of the Kidneys In Nitrogen Metabolismmentioning
confidence: 99%
“…The kidneys play an important role in correcting acidosis by enhanced production or excretion of ammonia. A large acid load initiates ammonia excretion while a basic load initiates ammonia production (Garibotto et al, 2004). Human rhesus (Rh) proteins expressed in erythroid cells and epithelial tissues have been described as ammonia transporters.…”
Section: The Role Of the Kidneys In Nitrogen Metabolismmentioning
confidence: 99%
“…The net effect of these processes is the generation of NH 3 [20]. Under normal acid-base conditions, the glutamine nitrogen extraction by the kidney is greater than the amount of ammonia produced, thus indicating that nitrogen supplied by glutamine extraction is more than sufficient to account for ammonia production [17].…”
Section: Ammonium Generation and Excretionmentioning
confidence: 99%
“…The renal excretion of acid (H + ) is achieved by titratable acidity and ammonium (NH 4 + ) excretion, with the latter playing a critical role in acid-base balance, specifically when endogenous acid production is enhanced [3]. Metabolic acidosis is generated consequent to either enhanced production of endogenous acid or decreased excretion of acid by the kidney [4].…”
Section: Introductionmentioning
confidence: 99%
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“…Um aumento rápido da reabsorção de glutamato e glutamina é necessário para a produção de bicarbonato de amônio, objetivando o aumento do pH sanguíneo (Mu X 1996). Estudos em pacientes com acidose metabólica crônica mostraram aumento de glutamina e glicina no sangue arterial (Garibotto 2004).…”
Section: Metabolômicaunclassified