Kidney stone formation and the gut microbiome are altered by antibiotics in genetic hypercalciuric stone-forming rats

Stern, Joshua M.; Burk, Robert D.; Asplin, John R.; Krieger, Nancy S.; Suadicani, Sylvia O.; Wang, Yi; Usyk, Mykhaylo; Lee, Justin A.; Chen, Luojing; Becker, Jennifer; Chan, Michaela; Bushinsky, David A.

doi:10.1007/s00240-020-01223-5

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…Exposure to antibiotics for at least two months resulted in a decrease in urine pH and urinary citrate levels, suggesting that there is a complex correlation between the gut and urinary tract in kidney stones [ 24 ]. These results were confirmed by Stern and colleagues [ 25 ]. Genetic hypercalciuric stone-forming rats were characterized by decreased urine pH and urinary citrate levels [ 25 ].…”

Section: Introductionsupporting

confidence: 83%

“…These results were confirmed by Stern and colleagues [ 25 ]. Genetic hypercalciuric stone-forming rats were characterized by decreased urine pH and urinary citrate levels [ 25 ]. Miller et al [ 26 ] confirmed previous reports which found that the multispecies bacterial network, containing, e.g., Ruminococcus , Oscillospira , Desulvovibrio and Methanobrevibacter , maintains oxalate homeostasis [ 26 ].…”

Section: Introductionsupporting

confidence: 83%

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Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Wigner

Bijak

Saluk‐Bijak

2022

Cells

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Nephrolithiasis ranks third among urological diseases in terms of prevalence, making up about 15% of cases. The continued increase in the incidence of nephrolithiasis is most probably due to changes in eating habits (high protein, sodium, and sugar diets) and lifestyle (reduced physical activity) in all developed countries. Some 80% of all kidney stones cases are oxalate urolithiasis, which is also characterized by the highest risk of recurrence. Frequent relapses of nephrolithiasis contribute to severe complications and high treatment costs. Unfortunately, there is no known effective way to prevent urolithiasis at present. In cases of diet-related urolithiasis, dietary changes may prevent recurrence. However, in some patients, the condition is unrelated to diet; in such cases, there is evidence to support the use of stone-related medications. Interestingly, a growing body of evidence indicates the potential of the microbiome to reduce the risk of developing renal colic. Previous studies have primarily focused on the use of Oxalobacterformigenes in patients with urolithiasis. Unfortunately, this bacterium is not an ideal probiotic due to its antibiotic sensitivity and low pH. Therefore, subsequent studies sought to find bacteria which are capable of oxalate degradation, focusing on well-known probiotics including Lactobacillus and Bifidobacterium strains, Eubacterium lentum, Enterococcus faecalis, and Escherichia coli.

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Section: Introductionsupporting

confidence: 83%

Section: Introductionsupporting

confidence: 83%

Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Wigner

Bijak

Saluk‐Bijak

2022

Cells

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“…Likewise, the effect of antibiotics such as ciprofloxacin and co-trimoxazole has also been studied in rats genetically predisposed to formation of calcium-based stones. Co-trimoxazole caused a decrease in urinary calcium, oxalate and citrate, an increase in urinary pH and an increase in calcification compared to ciprofloxacin [34 ▪ ]. In another study in rats where formation of calcium oxalate stones was induced by ethylene glycol, administration of an antibiotic cocktail significantly increased the presence of crystals, which was associated with a dramatic loss of bacterial diversity in feces [35 ▪ ].…”

Section: Gut Microbiome and Kidney Stone Diseasementioning

confidence: 95%

Role of microbiome in kidney stone disease

Galán-Llopis¹,

Sánchez-Pellicer

Navarro-López

2022

Current Opinion in Urology

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Purpose of reviewThe process of renal stone formation is complex, multifactorial, and variable depending on the type of stone. The microbiome, whether by direct or indirect action, is a factor that both promotes the formation and protects from developing of renal stones. It is a highly variable factor due to the great interindividual and intraindividual variability that it presents. In recent years, with the incorporation of nonculture-based techniques such as the high-throughput sequencing of 16S rRNA bacterian gene, both intestinal and urinary microbiota have been deeply studied in various diseases such as the kidney stone disease. Recent findingsThis review has examined the new insights on the influence of the intestinal and urinary microbiome in nephrolithiasis disease and its usefulness as a diagnostic and prognostic tool, highlighting its contribution to the pathogenesis, its ability to modulate it and to influence disease development.

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“…The involvement of the intestinal and urinary microbiota in the formation of calcium oxalate stone has been studied in humans [ 22 , 31 , 32 ], in rats [ 33 , 34 , 35 , 36 , 37 , 38 ], and in dogs [ 27 , 39 ], but not in cats. We hypothesized the following: (1) that mechanisms involving the microbiota, similar to those suspected in humans, might contribute to the formation of kidney calcium oxalate stones in cats, and (2) the use of antibiotics could lead to dysbiosis and thereby increase the risk of calcium oxalate stone formation.…”

Section: Introductionmentioning

confidence: 99%

Gut and Urinary Microbiota in Cats with Kidney Stones

Joubran,

Roux,

Serino

et al. 2024

Microorganisms

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Upper urinary tract urolithiasis is an emerging disease in cats, with 98% of kidney stones composed of calcium oxalate. In humans, disturbances in the intestinal and urinary microbiota are suspected to contribute to the formation of calcium oxalate stones. We hypothesized that similar mechanisms may be at play in cats. This study examines the intestinal and urinary microbiota of nine cats with kidney stones compared to nine healthy cats before, during, and after treatment with the antibiotic cefovecin, a cephalosporin. Initially, cats with kidney stones displayed a less diverse intestinal microbiota. Antibiotic treatment reduced microbiota diversity in both groups. The absence of specific intestinal bacteria could lead to a loss of the functions these bacteria perform, such as oxalate degradation, which may contribute to the formation of calcium oxalate stones. This study confirms the presence of a distinct urobiome in cats with kidney stones, characterized by greater richness and diversity compared to healthy cats. These findings highlight the potential of microbiota modulation as a strategy to prevent renal lithiasis in cats.

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Kidney stone formation and the gut microbiome are altered by antibiotics in genetic hypercalciuric stone-forming rats

Cited by 5 publications

References 38 publications

Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Role of microbiome in kidney stone disease

Gut and Urinary Microbiota in Cats with Kidney Stones

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