Kidney transplant recipients with polycystic kidney disease have a lower risk of post‐transplant <scp>BK</scp> infection than those with end‐stage renal disease due to other causes

Plafkin, Callie; Singh, Tripti; Astor, Brad C.; Parajuli, Sandesh; Bhutani, Gauri; Safdar, Nasia; Panzer, Sarah E.

doi:10.1111/tid.12974

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…Other risk factors with an increased risk of BKVAN include older age [13], ureteral stent placement [14], ABO incompatibility [15], rejection or ischemia of the transplanted kidney [16], delayed graft function [14], HLA mismatch [15], specific HLA-C alleles [17], BKV polymorphisms [18], and transplantation from an HCV-positive donor [19]. Factors associated with decreased risk include recipient HLA-B51 positivity [20], and polycystic kidney disease [21].…”

Section: Risk Factorsmentioning

confidence: 99%

BK Virus Infection and Its Management in Renal Transplantation: An Update

Chakrabarti¹,

Chaturvedy²,

Bajpai³

et al. 2023

OBM Transplant

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BK virus (BKV) is a common opportunistic pathogen in kidney transplant recipients and one of the most challenging causes of allograft dysfunction and loss. Although over-immunosuppression remains the primary risk factor for BKV infection after transplantation, male gender, older recipient age, prior rejection episodes, degree of human leukocyte antigen mismatching, prolonged cold ischemia time, BK virus serostatus and ureteral stent placement have all been implicated as risk factors. Routine screening post-renal transplant is important to prevent allograft loss in patients with BK viruria or viremia. Reduction of immunosuppression remains the mainstay of BKV nephropathy treatment and is the most studied intervention. In this review, we are going to discuss the epidemiology of BK virus infection, screening strategies, treatment options and new studies or evidence in the future.

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Section: Risk Factorsmentioning

confidence: 99%

BK Virus Infection and Its Management in Renal Transplantation: An Update

Chakrabarti¹,

Chaturvedy²,

Bajpai³

et al. 2023

OBM Transplant

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“…Recipient HLA-B51 positivity [ 55 ] and the presence of polycystic kidney disease [ 56 ] have been shown to be protective factors against the development of BKVAN. HLA-B51 positivity is associated with the presence of highly immunogenic cytotoxic T cells, which may explain the fivefold reduction in the occurrence of BKVAN in these patients [ 55 ].…”

Section: Epidemiologymentioning

confidence: 99%

BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review

Kant

Dasgupta

Bagnasco

et al. 2022

Viruses

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BK virus maintains a latent infection that is ubiquitous in humans. It has a propensity for reactivation in the setting of a dysfunctional cellular immune response and is frequently encountered in kidney transplant recipients. Screening for the virus has been effective in preventing progression to nephropathy and graft loss. However, it can be a diagnostic and therapeutic challenge. In this in-depth state-of-the-art review, we will discuss the history of the virus, virology, epidemiology, cellular response, pathogenesis, methods of screening and diagnosis, evidence-based treatment strategies, and upcoming therapeutics, along with the issue of re-transplantation in patients.

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“…When examining data from individual studies, risk factors for BKVAN can be divided into recipient-, donor- and allograft specific and include: male sex, older age of donor and recipient, cold ischemia time, delayed graft function, episodes of rejection, ureteral stent, use of anti-thymocyte globulin in induction, use of tacrolimus in maintenance therapy, ABO blood group system incompatibility, ischemia/reperfusion injury and recipient or donor seropositivity. Conversely, mTOR inhibitor use has been shown to be a protective factor [ 9 , 21 , 22 , 23 , 24 ].…”

Section: An Overview Of Bkv Infection and Bkvan In Kidney Transplamentioning

confidence: 99%

The Role of HLA and KIR Immunogenetics in BK Virus Infection after Kidney Transplantation

Kamenarić

Ivković

Vojtušek

et al. 2020

Viruses

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BK virus (BKV) is a polyomavirus with high seroprevalence in the general population with an unremarkable clinical presentation in healthy people, but a potential for causing serious complications in immunosuppressed transplanted patients. Reactivation or primary infection in kidney allograft recipients may lead to allograft dysfunction and subsequent loss. Currently, there is no widely accepted specific treatment for BKV infection and reduction of immunosuppressive therapy is the mainstay therapy. Given this and the sequential appearance of viruria-viremia-nephropathy, screening and early detection are of utmost importance. There are numerous risk factors associated with BKV infection including genetic factors, among them human leukocyte antigens (HLA) and killer cell immunoglobulin-like receptors (KIR) alleles have been shown to be the strongest so far. Identification of patients at risk for BKV infection would be useful in prevention or early action to reduce morbidity and progression to frank nephropathy. Assessment of risk involving HLA ligands and KIR genotyping of recipients in the pre-transplant or early post-transplant period might be useful in clinical practice. This review summarizes current knowledge of the association between HLA, KIR and BKV infection and potential future directions of research, which might lead to optimal utilization of these genetic markers.

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Kidney transplant recipients with polycystic kidney disease have a lower risk of post‐transplant BK infection than those with end‐stage renal disease due to other causes

Cited by 7 publications

References 22 publications

BK Virus Infection and Its Management in Renal Transplantation: An Update

BK Virus Infection and Its Management in Renal Transplantation: An Update

BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review

The Role of HLA and KIR Immunogenetics in BK Virus Infection after Kidney Transplantation

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