Kikuchi-Fujimoto disease: a rare but important differential diagnosis for lymphadenopathy

Srikantharajah, Mukunthan; Mahendra, Prem; Vydianath, Bindu; Lowe, Gillian

doi:10.1136/bcr-2014-205470

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…As with other case reports,8 18 we would like to highlight the importance of a proper differential diagnosis for lymphadenopathy. Our initial diagnostic suspicion was lymphoma; however, the histopathological features led us to the definitive diagnosis.…”

Section: Discussionmentioning

confidence: 66%

Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition

Carretero¹,

Brugera

Rebollo-Aparicio

et al. 2016

BMJ Case Reports

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Kimura disease is a benign rare chronic inflammatory disorder of unknown aetiology. This disease is mainly endemic in Asia, although cases have also been reported in Europe and America. We describe a case in a 34-year-old Chinese man presenting with severe eosinophilia and multiple lymphadenopathy. Since our initial aim was to rule out the diagnosis of lymphoma, and given the limitations of our laboratory, we decided to perform an excision of one of the cervical lymph nodes. The histological diagnosis was consistent with Kimura disease. We review the epidemiology, the aetiology and clinical features of this entity.

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Section: Discussionmentioning

confidence: 66%

Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition

Carretero¹,

Brugera

Rebollo-Aparicio

et al. 2016

BMJ Case Reports

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“…Other microorganisms such as herpes simplex, CMV, varicela zoster, HIV, Rubella, Measles, Coxsackie vírus, Hepatitis A (HAV) and HBV, Influenza virus, Leptospira and Chlamydia were also related [6]. An association with SLE, mixed connective tissue disease and Still's disease has also been postulated [19]. It is believed to be one of the self-limited causes of cervical lymphadenopathy, that is often under diagnosed [20].…”

Section: Discussionmentioning

confidence: 99%

“…This disorder is characterized by destruction of lymph node parenchyma, and typical findings include patchy areas of coagulative necrosis in the cortical and paracortical areas of enlarged lymph nodes, together with nuclear debris or extensive karyorrhexis [24]. Microscopic examination can also demonstrate paracortical foci of histiocytic infiltrate, with characteristic absence of neutrophils and eosinophils with few or no plasma cells [19]. The immunohistologic landscape of KFD is complex and characterized by increased numbers of plasmacytoid dendritic cells that frequently cluster around apoptotic/necrotic foci, increased cytotoxic T-cells, and substantial distortion of follicular dendritic cell mesh works [25].…”

Section: Sporadic Cases Of Kikuchi's Disease Have Been Reported Inmentioning

confidence: 99%

Kikuchi Fujimoto disease: A rare case of recurrence

Azevedo¹

2022

J Clin Images Med Case Rep

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Background: Kikuchi-Fujimoto’s Disease (KFD) is rare, benign and more frequent in Asia. It is characterized by the appearance of lymphadenopathies and fever. Histological examination of the lymph nodes make the diagnosis. It is a self-limited disease. Relapses rarely occur. Case presentation: We described a case in Europe, with the particularity of having presented recurrence. Man, 66-year-old, leukodermic, admitted for weight loss, fever, multiple lymphadenopathies, hepato-splenomegaly, severe bicytopenia and acute kidney injury. Infectious, autoimmune and haematological diseases were excluded. Histological examination of cervical lymphadenopathy was compatible with necrotic KFD. After corticosteroid therapy, the condition resolved. Two years later, he was hospitalized for similar symptoms, hepato-splenomegaly, mediastinal and lumboaortic lymphadenopathies. Recurrence of KFD was admitted Conclusions: This case report is intended to alert to the difficulty of diagnosing a rare cause of lymphadenopathies in the western world. The diagnosis isn´t obvious, required the exclusion of other, much more frequent causes and whose treatment is more specific.

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TB or not to be? Kikuchi-Fujimoto disease: a rare but important differential for TB

McKenna¹,

Whitfield

Patel

et al. 2017

BMJ Case Reports

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A 29-year-old British Pakistani woman presented with a 2-month history of drenching fevers, night sweats, lethargy and tender cervical and axillary lymphadenopathy. Initial investigations, bloods and imaging were unremarkable. Fever persisted during her admission, and treatment for tuberculosis (TB) lymphadenitis was started postbiopsy until histology confirmed a diagnosis of Kikuchi-Fujimoto's disease (KFD). KFD has a non-specific presentation of fever, night sweats and lymphadenopathy and commonly raises a clinical suspicion of a number of other serious conditions such as TB, lymphoma, HIV, systemic lupus erythematous, toxoplasmosis and infectious mononucleosis. Although rare, KFD should be considered to be a differential diagnosis for fever of unknown origin and tender lymphadenopathy in otherwise well individuals. This case demonstrates the importance of a timely histological biopsy diagnosis to prevent an incorrect diagnosis and administration of unnecessary medications.

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Kikuchi-Fujimoto disease: a rare but important differential diagnosis for lymphadenopathy

Cited by 5 publications

References 6 publications

Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition

Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition

Kikuchi Fujimoto disease: A rare case of recurrence

TB or not to be? Kikuchi-Fujimoto disease: a rare but important differential for TB

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