Kikuchi-Fujimoto disease and systemic lupus erythematosus

Baenas, Diego Federico; Diehl, Fernando A; Salinas, María Jezabel Haye; Riva, Verónica; Diller, Ana; Lemos, Pablo A

doi:10.2147/imcrj.s106396

Cited by 55 publications

(61 citation statements)

References 37 publications

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“…Baenas et al noted three patterns of presentation of association between KFD and SLE which are before the onset of SLE (30%), simultaneous occurrence of both disorders (47%), and KFD after SLE (23%) [16]. Goldblatt et al…”

Section: Discussionmentioning

confidence: 99%

Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis

Sharma

Otieno

Shah

2020

Case Reports in Medicine

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Kikuchi-Fujimoto disease (KFD) is a rare form of painful lymphadenopathy, usually cervical, which is more common in Southeast Asia and rarely reported from Africa. Symptoms are usually nonspecific (fever, night sweats, etc.), and can mimic more common diseases such as tuberculosis (TB) in endemic areas. We report a case of a 29-year-old black African woman who was admitted with headache, neck pain, fever, and lymphadenopathy. She was found to have aseptic meningitis, eventually attributed to TB based on cervical node biopsy, although further histology suggested KFD. Blood tests for systemic lupus erythematosus (SLE) were negative; she had already been commenced on anti-TB treatment and had responded well and so was continued with this therapy. She was also later diagnosed with Hashimoto's thyroiditis 3 months after her diagnosis of KFD. Five months after stopping TB treatment, she was readmitted with the same symptoms and associated painless lymphadenopathy. Repeat biopsy was morphologically similar to that of 2017, and repeat evaluation confirmed SLE. She has since been managed by a rheumatologist and continues to do well.

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Section: Discussionmentioning

confidence: 99%

Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis

Sharma

Otieno

Shah

2020

Case Reports in Medicine

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“…There are a lot of studies showing association between SLE and KFD, but the relationship is not clearly understood. 10,11,12 Histologically SLE differs from KFD in that it is associated with the presence of hematoxylin bodies, which are particles of denatured nuclear material. Londhey et al reported a case where a patient was initially diagnosed with KFD, but later went on to develop SLE, and suggested that it may precede, follow or coincide with the diagnosis of SLE.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease - A Clinical Enigma: Rare two Case Reports

Khura

Shakarwal²,

Kumar

et al. 2020

JoARM

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Background: Kikuchi-Fujimoto Disease (KFD) is a rare disease and is commonly seen in Asian population. It usually presents with prolonged fever, leukopenia and persistent cervical lymphadenopathy. It is a benign disease with a female preponderance. The cause is unknown but many theories have been postulated, like autoimmune, inflammatory, infectious agents and molecular mimicry. Most of the patients will recover themselves without any sequelae, in six-month time. However, it may rarely also convert to autoimmune disease, like SLE. The recurrence rate is very low. It is important to consider it as a differential diagnosis in chronic persistent lymphadenopathy, like tuberculosis, lymphoma, HIV and autoimmune lymphadenitis. Cases: Here we present a case of a 37-year-old female who initially went to a private practitioner with chief complaint of a persistent neck mass of approximately 6 months duration, multiple small joints pain and persistent fever. She underwent excisional biopsy for suspected lymphoma, but final pathology rendered a diagnosis of KFD. Second case also presented with multiple neck swelling and joint pains, suspect of SLE, connective tissue disorder or young-onset still's disease was made clinically but excisional biopsy revealed KFD. Both the patients improved with NSAIDS and low dose wysolone therapy. Conclusion: The purpose of this article is not only to review the literature but also to create awareness of this entity in the differential diagnosis of persistent lymphadenopathy, especially for the general otolaryngologist in a community-based setting. In addition, this review would be beneficial for other practitioners as well, specifically paediatricians, infectious disease physicians, rheumatologists, pathologists, and medical oncologists.

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“…Atypical lymphocytes may also be seen on a peripheral blood smear. 5 The origin of Kakuchi-Fujimoto Disease is unknown but a viral etiology has been hypothesized including Epstein-Barr virus, human herpes virus 6, rubella virus, parvovirus B19, varicella zoster, paromyxovirus and parainfluenza virus 4, 6 . There has been some postulation of possible genetic predisposition based on familial occurrence 6 , but this has not been clearly elucidated to date.…”

Section: Case Presentationmentioning

confidence: 99%

“…A review of 244 cases of Kakuchi-Fujimoto Disease in the literature by Kucukardali found 32 cases (13%) were associated with systemic lupus erythematosus 3 . A subsequent literature review described three patterns of presentation including KFD before the onset of SLE (30%), simultaneous occurrence of both disorders (47%) and KFD after SLE diagnosis (23%) 5 . Given this association, it is important to be aware of the possibility of these diagnoses occurring contemporaneously.…”

Section: Case Presentationmentioning

confidence: 99%

“…Ultimately, the definitive diagnosis is based on histopathology of biopsied lymph nodes, characterized by focal necrosis in cortical and paracortical areas surrounded by crescentic histiocytes, and importantly, absence of neutrophils 5 . This necrotizing lymphadenitis without neutrophils can be seen in either KFD or SLE-related lymphadenitis.…”

Section: Case Presentationmentioning

confidence: 99%

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