Killed Campylobacter elicits immune response and protection when administered with an oral adjuvant

Rollwagen, Florence M.; Pacheco, Nancy D.; Clements, John D.; Pavlovskis, O R; Rollins, David M.; Walker, Richard I.

doi:10.1016/0264-410x(93)90101-3

Cited by 57 publications

(36 citation statements)

References 17 publications

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“…Formalin-or heat-killed bacterial preparations or combinations of the two have been used as oral vaccines, with or without E. coli heat-labile toxin to enhance mucosal responses. Such vaccine preparations were shown to induce protective immunity in mice, ferrets, and nonhuman primates (15,17,36,141). Subunit vaccines based on FlaA were shown to induce short-term protective immunity in mice (100), and proteomics approaches are currently being used to identify Campylobacter surface proteins that could be included in subunit vaccines (137).…”

Section: Vaccine-induced Protectionmentioning

confidence: 99%

Host-Pathogen Interactions inCampylobacterInfections: the Host Perspective

et al. 2008

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SUMMARY Campylobacter is a major cause of acute bacterial diarrhea in humans worldwide. This study was aimed at summarizing the current understanding of host mechanisms involved in the defense against Campylobacter by evaluating data available from three sources: (i) epidemiological observations, (ii) observations of patients, and (iii) experimental observations including observations of animal models and human volunteer studies. Analysis of available data clearly indicates that an effective immune system is crucial for the host defense against Campylobacter infection. Innate, cell-mediated, and humoral immune responses are induced during Campylobacter infection, but the relative importance of these mechanisms in conferring protective immunity against reinfection is unclear. Frequent exposure to Campylobacter does lead to the induction of short-term protection against disease but most probably not against colonization. Recent progress in the development of more suitable animal models for studying Campylobacter infection has opened up possibilities to study the importance of innate and adaptive immunity during infection and in protection against reinfection. In addition, advances in genomics and proteomics technologies will enable more detailed molecular studies. Such studies combined with better integration of host and pathogen research driven by epidemiological findings may truly advance our understanding of Campylobacter infection in humans.

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Section: Vaccine-induced Protectionmentioning

confidence: 99%

Host-Pathogen Interactions inCampylobacterInfections: the Host Perspective

et al. 2008

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“…Mice with limited enteric flora and/or with spontaneous or targeted alterations in immune function have also been explored as possible models for C. jejuni infection, including nude BALB/c mice, C3H and SCID-C3H limited-flora mice, C.B-17-SCID-beige mice, and 129 ϫ C57BL/6 NF-B-deficient mice (16,40,56,73). Infant and adult mice have been inoculated intragastrically, intranasally, and intraperitoneally with C. jejuni for a variety of purposes including the elucidation of colonization and/or virulence mechanisms and host responses (27,29,30,59,64,67,73), screening of natural isolates or laboratory strains carrying spontaneous or targeted mutations that are thought to affect colonization and/or virulence (6,27,31,40,42,56,66,73), and evaluation of the efficacy of vaccines or therapeutic agents (4,36,58,73). However, to date, the majority of mouse models of Campylobacter infection are colonization models; if disease develops, it is inconsistent or atypical.…”

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confidence: 99%

C57BL/6 and Congenic Interleukin-10-Deficient Mice Can Serve as Models ofCampylobacter jejuniColonization and Enteritis

Mansfield¹,

Bell²,

Wilson³

et al. 2007

Infect Immun

104

184

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“…Campylobacter vaccine studies using mice have included oral delivery of killed whole cells (2), whole-cell lysates (29), protein delivery by Salmonella vectors (34), nasal delivery of recombinant flagellin (17), or parenteral delivery of recombinant proteins (26). At present none has been developed into an effective human vaccine.…”

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confidence: 99%