Killer cell immunoglobulin-like receptor genotypes in the Turkish population

Elbasi, Mehmet Onur; Virlan, Aysın Tulunay; Demiralp, Emel

doi:10.1016/j.humimm.2018.02.008

Cited by 1 publication

(2 citation statements)

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“…Although there was no significant difference in KIR haplotypes between RPL and healthy couples in our study, we found a statistically significant trend towards C2 homozygosity in the male partners of RPL couples, which might be a risk factor for the allogeneic fetus. However, the frequency of KR2DL1, a known ligand of HLA-C2, was excluded from our statistical analysis since it was detected in 100% of the sample of the general Turkish population and the RPL couples in our study [35]. Further studies to establish the genetic variants of KIR2DL1 linked to RPL would provide valuable information on the interactions between HLA-C2 and HLA-C2 ligands.…”

Section: Discussionmentioning

confidence: 97%

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Maternal killer-cell immunoglobulin-like receptors and paternal human leukocyte antigen ligands in recurrent pregnancy loss cases in Turkey

Elbasi

Tulunay

Karagozoglu³

et al. 2020

Clin Exp Reprod Med

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Objective: The survival of a semi-allogeneic fetus depends on several immunological mechanisms, and it has been suggested that recurrent pregnancy loss (RPL) could develop as a result of one or more immunological abnormalities.Methods: Compatibility between partners for human leukocyte antigen (HLA) genotypes and the relationships between maternal killer-cell immunoglobulin-like receptor (KIR) and paternal HLA-Bw4/Bw6 and HLA-C1/C2 supra-groups were investigated in 25 couples with RPL in comparison to healthy couples with children. HLA and KIR genotyping was performed using polymerase chain reaction with sequence-specific primers and/or sequence-specific oligonucleotides.Results: HLA class I incompatibility between partners, especially in HLA-B alleles, was more common in the RPL group (p= 0.01). HLA-C2 homozygosity was more frequent in the male partners of RPL couples than in other groups (p= 0.03). The KIR2DL5 gene frequency was significantly higher in both the female and male partners of RPL couples, whereas the KIR2DS3 gene frequency in male partners of RPL couples was significantly reduced (p= 0.03). The presence of KIR2DL3 in women with RPL was correlated with the presence of HLA-C2 alleles in their spouses (p= 0.03).Conclusion: Our data from a Turkish population suggest that male HLA-C2 homozygosity may play an important role in RPL. Additionally, an incidental match between male HLA-C2 and female HLA-C1 ligand KIR receptors might perturb the balance between activatory and inhibitory KIR-ligand interactions during pregnancy in couples affected by RPL. The roles of orphan KIR2DL5 and orphan KIR2DS3 in RPL remain obscure.

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Section: Discussionmentioning

confidence: 97%

“…The KIR gene frequencies were calculated by directly counting positive and negative loci, and KIR gene haplotypes were determined. Our KIR genotype data from healthy controls are available in the allele frequencies.net website with the name "Turkey KIR pop 3" [35].…”

Section: Kir Allele Typingmentioning

confidence: 99%