Killing three birds with one stone: Near-infrared light triggered nitric oxide release for enhanced photodynamic and anti-inflammatory therapy in refractory keratitis

Zhang, Hengrui; Jiang, Wenya; Peng, Yaou; Yang, Jie; Chu, Xiaoying; Long, Ziyue; Li, Renlong; Liang, Qiuwei; Suo, Hao; Wang, Zhen; Yang, Mei; Qi, Ji; Yang, Ying‐Wei; Wang, Bailiang

doi:10.1016/j.biomaterials.2022.121577

Cited by 52 publications

(25 citation statements)

References 53 publications

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“…The antibacterial property in vitro was tested through traditional spread plate method, and the bacteriostasis was evaluated intuitively by comparing the number of viable bacteria ( Zhang et al, 2022a ). The bacterial growth in the plate was recorded and the antimicrobial rate of TTVP was calculated.…”

Section: Resultsmentioning

confidence: 99%

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

Cai

Shen²,

Wang³

et al. 2023

Front. Chem.

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Bacterial keratitis (BK) is an acute infection of the cornea, accompanied by uneven epithelium boundaries with stromal ulceration, potentially resulting in vision loss. Topical antibiotic is the regular treatment for BK. However, the incidence rate of multidrug-resistant bacteria limits the application of traditional antibiotics. Therefore, a cationic aggregation-induced emission luminogens (AIEgens) named TTVP is utilized for the treatment of BK. TTVP showed no obvious cytotoxicity in maintaining the normal cell morphology and viability under a limited concentration, and revealed the ability to selectively combine with bacteria in normal ocular environment. After light irradiation, TTVP produced reactive oxygen species (ROS), thus exerting efficient antibacterial ability in vitro. What’s more, in rat models of Staphylococcus aureus (S. aureus) infection, the therapeutic intervention of TTVP lessens the degree of corneal opacity and inflammatory infiltration, limiting the spread of inflammation. Besides, TTVP manifested superior antibacterial efficacy than levofloxacin in acute BK, endowing its better vision salvage ability than conventional method. This research demonstrates the efficacy and advantages of TTVP as a photodynamic drug in the treatment of BK and represents its promise in clinical application of ocular infections.

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Section: Resultsmentioning

confidence: 99%

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

Cai

Shen²,

Wang³

et al. 2023

Front. Chem.

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“…Recently, several in vivo applications based on APDT to treat bacterial keratitis have been reported. These applications have employed traditional PS such as the Rose Bengal [191] and Chlorin e6, [157,192] organic dyes like boron dipyrromethene (BODIPY) [60,187] and aggregated‐induced emission molecules [193,194] …”

Section: In Vivo Applications Of Apdtmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Xin

Kwek

et al. 2023

ChemPlusChem

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The emergence of multi‐drug resistant bacteria strains has been an uphill battle in modern healthcare worldwide, due to the increasing difficulty of killing them. The evolving pathogenicity of bacteria has led to researchers searching for more effective antimicrobial therapeutics to successfully eliminate them without undesirable consequences to the human body. In recent years, antimicrobial photodynamic therapy (APDT), an obsolete technique for cancer treatments, has been reported to eradicate bacteria and biofilm‐related infections. The principle of antimicrobial photodynamic therapy solely relies on the photosensitizers (PSs) generating reactive oxygen species, in the presence of oxygen and light, to destroy pathogens. Thus, it can target a broad spectrum of microorganisms, owing to the indirect interaction between PSs and the bacteria, resulting in the less likelihood for the development of drug resistant bacteria strains. This review will focus on the recent progress of APDT in the last five years and some future perspectives of APDT. The mechanism of APDT against bacteria and biofilms, various PSs used for APDT, and some common multidrug‐resistant bacteria strains will be briefly introduced. The reported in vivo applications of APDT in the several types of bacterial infections that includes periodontitis, wound infections, keratitis, endophthalmitis and tuberculosis in the last five years will be summarized in detail.

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“…41 However, due to the short lifetime and diffusion distance of both O À 2 and NO, the in situ efficient formation of ONOO À becomes a big challenge. [42][43][44][45][46][47] Therefore, it would be a promising and practical strategy to combine photosensitizers and NO donors, which can not only achieve in situ controllable formation of ONOO À in the infected region during the phototherapeutic process, but also cooperate with 1 O 2 from the Type-II PDT to enhance antibacterial efficiency of phototherapy.…”

Section: Introductionmentioning

confidence: 99%

In situ generation of peroxynitrite (ONOO⁻) for enhanced antibacterial photodynamic therapy

et al. 2023

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Killing three birds with one stone: Near-infrared light triggered nitric oxide release for enhanced photodynamic and anti-inflammatory therapy in refractory keratitis

Cited by 52 publications

References 53 publications

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

In situ generation of peroxynitrite (ONOO⁻) for enhanced antibacterial photodynamic therapy

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Killing three birds with one stone: Near-infrared light triggered nitric oxide release for enhanced photodynamic and anti-inflammatory therapy in refractory keratitis

Cited by 52 publications

References 53 publications

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

In situ generation of peroxynitrite (ONOO−) for enhanced antibacterial photodynamic therapy

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Product

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About

In situ generation of peroxynitrite (ONOO⁻) for enhanced antibacterial photodynamic therapy