Kimura Disease: A case report with bilateral upper lid masses and a right parotid mass

Negre, Geraldine Clare Marie P; Regala, Fatima G; Ang, Charmaine Y; Tumalad, Marco A

doi:10.1080/01676830.2022.2058022

Cited by 1 publication

(1 citation statement)

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“…To our knowledge, there are only five published cases of KD in Filipino patients, and none of them had this type of adenopathies. The reported Filipino patients showed the following clinical findings: periauricular mass and cervical adenopathies in two patients, parotid mass and periorbital inflammation in two other patients and left upper eyelid inflammation and left lacrimal gland mass in one patient (11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge

Laguna

Rodríguez-García

Molina

et al. 2023

Biochem. med. (Online)

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Kimura disease (KD) is an unusual inflammatory disease of unknown etiology. Despite being described many years ago, KD might cause diagnostic difficulty or be confused with other conditions. Here, we present a 33-year-old Filipino woman who was referred to our hospital for evaluation of persistent eosinophilia and intense pruritus. Blood analysis and peripheral blood smear review showed high eosinophil counts (3.8 x10 9 /L, 40%) that did not show morphological abnormalities. Besides, high serum IgE concentration was detected (33,528 kU/L). Serological tests were positive for Toxocara canis and treatment with albendazol was initiated. Nevertheless, increased eosinophil counts were still present after several months, alongside with high serum IgE concentrations and intense pruritus. During her follow-up, an inguinal adenopathy was detected. The biopsy revealed lymphoid hyperplasia with reactive germinal centers and massive eosinophil infiltration. Proteinaceous deposits of eosinophilic material were also observed. All these findings, together with peripheral blood eosinophilia and high IgE concentrations, confirmed the diagnosis of KD. The diagnosis of KD should be considered in the differential diagnosis of long-standing unexplained eosinophilia in association with high IgE concentrations, pruritus and lymphadenopathies.

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Section: Discussionmentioning

confidence: 99%