Kimura Disease: Diagnosis and Prognostic Factors

Iwai, Hiroshi; Nakae, Kaoru; Ikeda, Koshi; Ogura, Manabu; Miyamoto, Makoto; Omae, Mariko; Kaneko, Toshihiko; Yamashita, Toshio

doi:10.1016/j.otohns.2007.03.027

Cited by 61 publications

(46 citation statements)

References 13 publications

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“…A previous report had shown that a high PB eosinophil count can be used as a risk factor for recurrence in KD [23]. In our study, the PB eosinophil count at diagnosis was higher in patients with recurrence than in patients without recurrence, but the difference did not reach statistical significance.…”

Section: Discussioncontrasting

confidence: 86%

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Kottler

Barète

Quéreux³

et al. 2015

Dermatology

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Background: Kimura disease (KD) is a rare lymphoproliferative inflammatory disease of unknown etiology. Data regarding therapeutic modalities and pathophysiology are scarce. Objectives: Analyze therapeutic and follow-up data and compare KD with cutaneous IgG4-related disease (IgG4-RD). Methods: Multicentric retrospective study of 25 KD patients with analysis of treatment, follow-up and IgG4 immunostaining. Comparison with published cases of cutaneous IgG4-RD. Results: Patients were mostly male (84%), median-aged 42 years with lymph node, lacrimal/salivary gland and kidney involvements in 45, 24 and 12%, respectively. Surgical excision had 100% complete response and 60% relapse. Oral corticosteroids had 100% response with 50% relapse. Thalidomide, cyclosporine or interferon-α had 100% response, but 100, 20 and 50% relapse, respectively. KD showed clinicopathological similarities with 27 published cases of cutaneous IgG4-RD. Conclusion: Surgery may be used in resectable KD cases, whereas cyclosporine or thalidomide may represent interesting alternatives to oral corticosteroids in other cases. KD shares features with cutaneous IgG4-RD.

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Section: Discussioncontrasting

confidence: 86%

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Kottler

Barète

Quéreux³

et al. 2015

Dermatology

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“…Other sites such as the oral cavity, axilla, groin, limbs, and trunk have also been described, but the involvement of the respiratory tract is rare. To our knowledge, 10 cases of KD centered around the epiglottis have appeared in the English and Japanese literature [7][8][9][10][11][12][13][14][15][16]. Our case provides an additional example (Table 1).…”

Section: Discussionmentioning

confidence: 85%

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

Yamamoto

Minamiguchi

Watanabe

et al. 2013

Head and Neck Pathol

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Kimura disease (KD) affecting an unusual site is a diagnostic challenge. We report herein the case of a 62-yearold Japanese woman who presented with swelling of the epiglottis, resulting in airway narrowing. Microscopically, biopsied and resected specimens both revealed lymphoid proliferation of a reactive immunophenotype, accompanied by vascular proliferation, eosinophilic infiltration, and stromal sclerosis. Adjunctive immunohistochemistry with immunoglobulin E in addition to laboratory and histological findings led us to seriously consider a diagnosis of KD. The patient underwent surgical removal with postoperative steroid therapy and has no evidence of recurrence. Our experience suggests that KD is potentially fatal as well as showing difficulty in the histological diagnosis when occurring in the upper respiratory tract, such as the epiglottis. A literature review disclosed that our case is the 11th case so far reported in this location, and that KD of the epiglottis did not show any male preponderance, as seen in other places.

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“…Iwai et al had described blood eosinophilia at mean count of 35.2% with elevated IgE in all Kimura's cases. 5 The patient reported here also has eosinophilia and elevated serum IgE levels. Kimura's disease can be mistaken easily for a malignant tumor like acute lymphocytic leukemia, T-cell lymphoma, Hodgkin's etc., among others.…”

Section: Discussionmentioning

confidence: 61%

A rare cause of bilateral postaural lymphadenopathy: Kimura’s disease

Batra

Goyal

Goel

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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<p>Kimura’s disease (KD) is a chronic inflammatory disorder with angiolymphatic proliferation of unknown etiology, usually affecting young men of Asian race but is rare in other races. Affected Indians are very rare. Herein, we present an atypical manifestation of Kimura’s disease occurring in an Indian male who presented with bilateral postaural lymphadenopathy. The diagnosis of Kimura’s disease can be very difficult and misleading; it is important not to ignore histopathological features.</p>

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Kimura Disease: Diagnosis and Prognostic Factors

Abstract: A preoperative decision based on our diagnostic criteria and prognostic factors should lead to better therapeutic outcomes for Kimura disease, for which a definitive treatment policy has never been determined.

Cited by 61 publications

References 13 publications

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease

Kimura Disease of the Epiglottis: A Case Report and Review of Literature

A rare cause of bilateral postaural lymphadenopathy: Kimura’s disease

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