Kimura’s Disease: A Diagnostic and Therapeutic Challenge

An, Gupta; Shareef, Mohamed; Lade, Himani; Ponnusamy, Sabri Rajan; Mahajan, Anukaran

doi:10.1007/s12070-019-01601-5

Cited by 10 publications

(5 citation statements)

References 4 publications

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“…However, surgery has been considered the primary treatment for KD, and radiotherapy is used for patients with incomplete resections or recurrences. In patients who do not want to be treated by surgery, immunosuppressive medications can be used ( 3 , 19 , 20 ). However, in recent years a new therapeutic option based on the use of antibodies is emerging.…”

Section: Discussionmentioning

confidence: 99%

Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge

Laguna

Rodríguez-García

Molina

et al. 2023

Biochem. med. (Online)

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Kimura disease (KD) is an unusual inflammatory disease of unknown etiology. Despite being described many years ago, KD might cause diagnostic difficulty or be confused with other conditions. Here, we present a 33-year-old Filipino woman who was referred to our hospital for evaluation of persistent eosinophilia and intense pruritus. Blood analysis and peripheral blood smear review showed high eosinophil counts (3.8 x10 9 /L, 40%) that did not show morphological abnormalities. Besides, high serum IgE concentration was detected (33,528 kU/L). Serological tests were positive for Toxocara canis and treatment with albendazol was initiated. Nevertheless, increased eosinophil counts were still present after several months, alongside with high serum IgE concentrations and intense pruritus. During her follow-up, an inguinal adenopathy was detected. The biopsy revealed lymphoid hyperplasia with reactive germinal centers and massive eosinophil infiltration. Proteinaceous deposits of eosinophilic material were also observed. All these findings, together with peripheral blood eosinophilia and high IgE concentrations, confirmed the diagnosis of KD. The diagnosis of KD should be considered in the differential diagnosis of long-standing unexplained eosinophilia in association with high IgE concentrations, pruritus and lymphadenopathies.

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Section: Discussionmentioning

confidence: 99%

Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge

Laguna

Rodríguez-García

Molina

et al. 2023

Biochem. med. (Online)

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“…Differential diagnoses of KD include angiolymphoid hyperplasia with eosinophilia, Kikuchi‐Fujimoto disease, Sjögren's syndrome, infective parotitis, parotid neoplasms, lymphoma, lymphadenopathy, and hemangioma 19–21 . The right impression is essential to ensure optimal treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…13,18 Differential diagnoses of KD include angiolymphoid hyperplasia with eosinophilia, Kikuchi-Fujimoto disease, Sjögren's syndrome, infective parotitis, parotid neoplasms, lymphoma, lymphadenopathy, and hemangioma. [19][20][21] The right impression is essential to ensure optimal treatment outcomes. Our patient was initially diagnosed with cavernous hemangioma based on the tumors' appearance and their imaging features.…”

Section: Takenaka Et Al Proposed a Mechanism Regarding Antigens Frommentioning

confidence: 99%

Kimura's disease as a mimicker of cavernous hemangioma: A case report and literature review

Wen‐Chieh,

Kuan‐Hui,

Li‐Yu

et al. 2023

Int J of Rheum Dis

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Kimura's disease (KD) is an immune‐mediated disorder which mainly affects Asian men. It appears as head and neck subcutaneous masses, with inflammatory infiltrate and elevated serum immunoglobulin E levels. The clinical presentation of KD resembles that of various diseases. Here, we report the case of a 30‐year‐old Filipino man with KD mimicking cavernous hemangioma who was treated by surgery. Careful survey for possible KD cases is crucial. Misdiagnoses are prone to futile interventions and unwanted effects. Surgery with adjuvant therapy is superior to other forms of KD treatment.

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“…Some authors were able to diagnose Kimura’s disease on FNAC [ 13 ], whereas others have reported the swellings as lymphadenitis or malignancies [ 14 , 15 ]. The characteristic features of Kimura’s disease on FNAC are the presence of significant numbers of eosinophils in a background of lymphoid cells, with fragments of collagenous tissue, endothelial cells and occasional polykaryocytes [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Kimura’s disease: a rare cause of chronic neck lymphadenopathy

Kok

Lim

2021

Journal of Surgical Case Reports

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Kimura’s disease is a rare chronic inflammatory disorder of unknown etiology which typically presents with subcutaneous nodules in the head and neck region and is frequently associated with regional lymphadenopathy or salivary gland enlargement. Peripheral blood eosinophilia and elevated serum immunoglobulin E levels are constant features of the disease. We present herein a 31-year-old male patient who presented with chronic neck lymphadenopathy. Kimura’s disease was diagnosed on fine needle aspiration cytology, the patient initially decided not to have further intervention. He presented 6 years later with lymphadenopathy and was treated with surgery. The diagnosis of Kimura’s disease was confirmed on histopathology. This patient had the disease for 6 years and did not have the typical features of peripheral eosinophilia and raise serum IgE level.

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Kimura’s Disease: A Diagnostic and Therapeutic Challenge

Cited by 10 publications

References 4 publications

Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge

Kimura disease as an uncommon cause of persistent hypereosinophilia: a diagnostic challenge

Kimura's disease as a mimicker of cavernous hemangioma: A case report and literature review

Kimura’s disease: a rare cause of chronic neck lymphadenopathy

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