2018
DOI: 10.1038/s41598-018-21430-w
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Kinesthetic stimulation for obstructive sleep apnea syndrome: An “on-off” proof of concept trial

Abstract: Obstructive sleep apnea (OSA) occurs when the upper airway narrows or collapses due to the loss of upper airway muscle activation at sleep onset. This study investigated the effectiveness of triggered kinesthetic stimulation in patients with OSA. This proof-of-concept, open-label, multicenter prospective study was conducted on 24 patients with severe OSA. During a one night evaluation, kinesthetic stimulation was intermittently delivered in 30 minute periods. The duration of apneas and hypopneas during Stimon … Show more

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Cited by 6 publications
(5 citation statements)
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“…Studies in humans and animals have suggested that compared with direct unilateral hypoglossal nerve stimulation, sciatic nerve stimulation, 87 esophageal distention, 88 electrical auricular stimulation, 89 and pulsed nasal insufflation of heated and humidified air 90 can activate and upregulate respiratory brainstem motor nuclei. 91 Such reflexes seem to engage a coordinated brainstem response involving several cranial nerves and upper airway muscles, perhaps more broadly than targeted efferent stimulation approaches. Early findings suggest a role for sensory stimulation in ameliorating OSA.…”
Section: Upper Airway Afferent Activationmentioning
confidence: 99%
“…Studies in humans and animals have suggested that compared with direct unilateral hypoglossal nerve stimulation, sciatic nerve stimulation, 87 esophageal distention, 88 electrical auricular stimulation, 89 and pulsed nasal insufflation of heated and humidified air 90 can activate and upregulate respiratory brainstem motor nuclei. 91 Such reflexes seem to engage a coordinated brainstem response involving several cranial nerves and upper airway muscles, perhaps more broadly than targeted efferent stimulation approaches. Early findings suggest a role for sensory stimulation in ameliorating OSA.…”
Section: Upper Airway Afferent Activationmentioning
confidence: 99%
“…A first description of our system and our preliminary results showing reduction in apneas duration and desaturations were described in [2]. In [1], we studied 24 patients from 5 centers, compared to 8 patients in a single center in the work by Waeber et al Our results in a larger population extended the knowledge by demonstrating that responses to stimulation therapy are clearly patient-specific, requiring to adapt stimulation intensity over time. Further development of our solution was based on the optimal, patient-specific and adaptive mechanical stimulation.…”
mentioning
confidence: 65%
“…The PSG system used was a Deltamed BrainBox 1042 (Natus, France) with the Cohrence software version 6.1.3.405, a Nonin Xpod Oximeter and a Braebon Ultima Airflow Pressure sensor. PSG data acquired during the HYPNOS study were evaluated by a single scorer at the core-laboratory of the project (CHU Grenoble), with quality assured by an intra-scorer quality control process [27]. Annotations included the instant of occurrence of obstructive, central and mixed apneas, hypopneas, the sleep state and body position, among others.…”
Section: B Clinical Datamentioning
confidence: 99%