Kinetic and Mechanistic Studies of Oxidation of Paracetamol by Bromamine-T in Acid Solutions

Bromamine-T (TsNBrNa): A Biologically Significant, Versatile Bromo-Organic Reagent

“…Puttaswamy and co-workers found that the oxidation of paracetamol with bromamine-T displays first-order dependence on BAT and fractional-order dependence on both [paracetamol] and [H + ] in HClO 4 medium at 303 K (Scheme 56 ). 81 It was observed that a change in the ionic strength of the medium, the addition of the reduction product of BAT and halide ions did affect the reaction kinetics. However, the dielectric constant of the solvent shows a positive effect on the reaction rate, along with an isotope effect of k ′(H 2 O)/ k ′(D 2 O) = 0.88.…”

“…Gowda et al investigated the kinetics involved in the ruthenium(III) chloride catalysed oxidation of secondary alcohols into their corresponding ketones by bromamine-T (BAT) (Scheme 58 ). 85 2-Propanol, 2-butanol, 2-pentanol, 2-hexanol and 2-heptanol were oxidised in acidic medium (HCl) at 30 °C. The reactions follow first-order kinetics with respect to [BAT] and fractional-order kinetics with respect to [alcohol], [Ru(III)], and [H + ].…”