Kinetic characteristics of de novo and secondary AML cells influence their response to haemopoietic growth factor (HGF) priming and correlate with clinical outcome

Ma, Smith; Smith, J. T.; Pallister, C. J.; Singer, Charles R.J.

doi:10.1016/s0145-2126(99)00125-3

Cited by 9 publications

(2 citation statements)

References 26 publications

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“…However, the readout can depend on the culture conditions 3 . Another possibility is assessment of cell surface receptors, however experimental data suggest that presence of growth factor receptors not automatically implies response of cells to these factors 58 . Further complications arise from evidence suggesting that hematopoietic growth factors can interact with their receptors inside the cell, which would imply that autocrine loops not necessarily depend on surface receptor expression 59 .…”

Section: Discussionmentioning

confidence: 99%

Mathematical modeling of the impact of cytokine response of acute myeloid leukemia cells on patient prognosis

Stiehl

Marciniak–Czochra

2018

Sci Rep

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Acute myeloid leukemia (AML) is a heterogeneous disease. One reason for the heterogeneity may originate from inter-individual differences in the responses of leukemic cells to endogenous cytokines. On the basis of mathematical modeling, computer simulations and patient data, we have provided evidence that cytokine-independent leukemic cell proliferation may be linked to early relapses and poor overall survival. Depending whether the model of cytokine-dependent or cytokine-independent leukemic cell proliferation fits to the clinical data, patients can be assigned to two groups that differ significantly with respect to overall survival. The modeling approach further enables us to identify parameter constellations that can explain unexpected responses of some patients to external cytokines such as blast crisis or remission without chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Mathematical modeling of the impact of cytokine response of acute myeloid leukemia cells on patient prognosis

Stiehl

Marciniak–Czochra

2018

Sci Rep

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“…A similar approach is already well documented in ANLL, where G-CSF is given concomitantly with fludarabine and cytosine arabinoside (FLAG). Our group has shown variable kinetic and clonogenic responses of ANLL progenitors to SCF in combination with other cytokines [64, 65]. Given this observation, if priming with cytokines is to be exploited it may become necessary to undertake individual pre-treatment testing.…”

Section: Scf As a Priming Agent In Anllmentioning

confidence: 99%

Stem Cell Factor: Biology and Relevance to Clinical Practice

Pallister

Smith

2001

Acta Haematol

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The type III tyrosine kinase receptor c-KIT and its ligand stem cell factor (SCF; also known as KIT ligand, mast cell growth factor and steel factor) are closely involved in the regulation of a wide range of tissues at different stages of life. This review provides an outline of the discovery, structure and expression of SCF and c-KIT but concentrates on their respective roles in the regulation of human haemopoiesis and how this knowledge might be exploited in the clinical setting.

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Haemopoietic cytokines

Lewis¹,

Gordon²

2003

The Cytokine Handbook

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Kinetic characteristics of de novo and secondary AML cells influence their response to haemopoietic growth factor (HGF) priming and correlate with clinical outcome

Cited by 9 publications

References 26 publications

Mathematical modeling of the impact of cytokine response of acute myeloid leukemia cells on patient prognosis

Mathematical modeling of the impact of cytokine response of acute myeloid leukemia cells on patient prognosis

Stem Cell Factor: Biology and Relevance to Clinical Practice

Haemopoietic cytokines

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