Kinetic release studies of nitrogen-containing bisphosphonate from gum acacia crosslinked hydrogels

Aderibigbe, B. A.; Varaprasad, Kokkarachedu; Sadiku, Rotimi; Ray, Suprakas Sinha; Mbianda, Xavier Yangkou; Fotsing, Marthe Carine Djuidje; Owonubi, Shesan John; Agwuncha, Stephen C.

doi:10.1016/j.ijbiomac.2014.10.064

Cited by 48 publications

(18 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 GA acts as a natural binding agent, which possesses antimicrobial activity and nds wide use in therapeutic applications like wound dressing materials. 41 Thus, the biphasic drug release prole of PRWSc observed in this study is due to the presence of AV-GA hydrogel base. This might have also contributed to the faster wound healing of the surgical wound sutured with PRWSc by inhibiting microbial colonization on the sutures surface.…”

Section: Discussionmentioning

confidence: 60%

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 60%

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Like guar gum, gum acacia is also cheap, non‐toxic, and biodegradable. Additionally, gum acacia has been reported to have anti‐bacterial and anti‐inflammatory properties …”

Section: Introductionmentioning

confidence: 99%

Development of ionic and non‐ionic natural gum‐based bigels: Prospects for drug delivery application

Sahoo

Singh

Uvanesh

et al. 2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

Recently, much attention has been focused on the development of gel based formulations for controlled drug delivery applications. Herein, we report the effect of the ionic (gum acacia) and the non-ionic (guar gum) gums on the properties of the bigels prepared with fluid-filled organogels. The microscopic study suggested the presence of flocculated structure in guar gum bigel, whereas, a de-flocculated structure was observed in gum acacia bigel. Infrared spectroscopy suggested the presence of polysaccharides in the bigels. The mechanical properties of the guar gum bigel were better than gum acacia bigel. The conductivity and the release properties suggested superior properties of gum acacia bigel. This indicated that the ionic nature of acacia bigel played a major role in controlled drug delivery, making it a potential bigel for desired pharmaceutical applications.

show abstract

“…The natural base materials, AV and GA used together as the drug loading agent, facilitate the sustained drug release. 41,42 AV assists the drug release mechanism through a biphasic mode; initially by breaking the drug embedded polymeric matrix, followed by diffusion. 41 Also, gum acacia possesses the ability to hold the loaded drug in the wound area for a longer duration.…”

Section: In Vitro Drug Release Kineticsmentioning

confidence: 99%

Development of banana (Musa balbisiana) pseudo stem fiber as a surgical bio-tool to avert post-operative wound infections

et al. 2018

View full text Add to dashboard Cite

show abstract

Kinetic release studies of nitrogen-containing bisphosphonate from gum acacia crosslinked hydrogels

Cited by 48 publications

References 43 publications

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

Antimicrobials tethering on suture surface through a hydrogel: a novel strategy to combat postoperative wound infections

Development of ionic and non‐ionic natural gum‐based bigels: Prospects for drug delivery application

Development of banana (Musa balbisiana) pseudo stem fiber as a surgical bio-tool to avert post-operative wound infections

Contact Info

Product

Resources

About