Kinetic roughening of the Kossel (100) surface: comparison of classical criteria with Monte Carlo results

Early Onset of Kinetic Roughening due to a Finite Step Width in Hematin Crystallization

“…Hematin crystallization is the main pathway employed by malaria parasites to sequester toxic hematin, released during hemoglobin digestion [31]; its inhibition is considered the most successful target for antimalarial drugs [32]. Here, we use in situ atomic force microscopy (AFM) to show that the transition occurs at a supersaturation significantly lower than that predicted by published criteria [9,10,14,22,[33][34][35][36]. We demonstrate that the transition is controlled by the balance between nucleation of new layers and their coalescence into smooth surfaces.…”

“…The hematin crystal structure [38] in Supplemental Material [26] implies that the coordination number of the hematin molecules in the crystal is Z ¼ 8. The mean ψ ¼ 2jΔH Criteria for the onset of kinetic roughening include vanishing R c (critical radius of the 2D nucleus) and the corresponding barrier for 2D nucleation, ΔG Ã , at high supersaturation [9,10,[35][36][37]. According to the classical nucleation theory (CNT), applied to 2D islands on a crystal substrate [39], island nuclei form as a result of fluctuations of the concentration of molecules on the surface.…”

“…Two characteristic length scales have been put forth: the correlation length of the step contour ξ, illustrated in Fig. 2(b) [41], or the size of one solute molecule a [10,35,36].…”

Needle Crystal Morphology Explained

“…Above this threshold driving force the face also becomes rough and therefore rounded off. One then speaks of kinetical roughening [3,4].…”

Materials Engineering of Solid-State Dosage Forms

“…Uncovering the mechanistic role played by solvent in enhancing or inhibiting crystal growth has been evolved in two general thoughts. In one theory, it is suggested that solventsurface interactions result in the change of interfacial tension, causing so-called surface roughening and variations in growth rate of crystal faces (2). Alternatively, it is proposed that solvent molecules act in a similar way to additives, preferentially adsorbed on specific faces, posing an additional energy barrier for solute molecules to attach to solid surfaces (3).…”