Brice, SM, Doma, K, and Spratford, W. Effect of footwear on the biomechanics of loaded back squats to volitional exhaustion in skilled lifters. J Strength Cond Res 36(10): 2676-2684, 2022-This study examined whether footwear influences the movement dynamics of barbell back squats to volitional exhaustion in experienced lifters. Eleven men (1 repetition maximum [1RM] 5 138 6 19 kg; 1RM % body mass 5 168 6 18%) performed 3 sets (5-12 6 4 repetitions per set) of loaded barbell back squats to volitional exhaustion using raised-heel and flat-heel footwear. Barbell motion as well as moments, angles, angular velocity, and power in the sagittal plane at the ankle, knee, hip, and lumbopelvis were examined during the second repetition of the first set (T second ) and the final repetition of the third set (T final ). There were significant reductions (p , 0.05) in lower-limb concentric angular velocity and power output for both footwear conditions. For the raised-heel condition at T final , hip and knee concentric angular velocities were significantly slower (p , 0.05), and knee concentric power output was significantly less (p , 0.05) compared with the flat-heel condition. A reduction in barbell velocity was not observed for the raised-heel condition despite there being reduction in hip and knee angular velocities. Furthermore, no differences were identified in lower-limb joint moments or any of the biomechanical characteristics of the lumbopelvis between the footwear conditions. The findings of this study suggest that neither type of footwear reduced joint loading or improved joint range-of-motion.