Kinetic solubility and dissolution velocity of rutin nanocrystals

Mauludin, Rachmat; Müller, Rainer H.; Keck, Cornelia M.

doi:10.1016/j.ejps.2008.12.002

Cited by 147 publications

(87 citation statements)

References 32 publications

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“…So the nanocrystal suspension (nanosuspension) containing nano-sized particles shows enhanced solubility. The enhancement of solubility of CUR-NS was consistent with the previous studies of nanosuspension for poorly soluble drugs such as asulacrine and rutin (Ganta et al, 2008;Mauludin et al, 2009).…”

Section: Characterization Of Cur-nssupporting

confidence: 79%

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Preparation and characterization of intravenously injectable curcumin nanosuspension

Gao

Sun

et al. 2010

Drug Delivery

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Section: Characterization Of Cur-nssupporting

confidence: 79%

“…Solubility of CUR-NS or PM was determined by shake-flask method (Mauludin et al, 2009). Excess amount of CUR, dried nanosuspension powder, and PM were added in water and equilibrated in a shaker water bath (HZ-92 1K, Taicang Instrument Ltd., Taicang, China) at 37°C for 48 h, respectively.…”

Section: Solubility Measurementmentioning

confidence: 99%

Preparation and characterization of intravenously injectable curcumin nanosuspension

Gao

Sun

et al. 2010

Drug Delivery

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“…As the driving force of precipitation is gradually reduced, the concentration of the bulk solution finally reaches a plateau, which is the constant saturation solubility, C s (ie, the equilibrium solubility). The concentration of the bulk solution C x , usually measured in practice, is called the kinetic solubility, 8 which is a metastable state, and eventually returns to the equilibrium solubility ( Figure 8B). This process happens when the concentration gradient is high enough.…”

Section: Solubility Of Coenzyme Q 10 Nanocrystals and Bulk Drugmentioning

confidence: 99%

“…Increasing the solubility and dissolution rate is a promising approach. In this context, nanonization, ie, a reduction in particle size so that at least one dimension measures less than 1000 nm, has been developed based on theoretical considerations, such as the Ostwald-Freundlich equation, 2,3,5,7,8 the Noyes-Whitney equation, 2,4,6-8 the Prandtl equation, 2,5,9 and Ostwald ripening. 7 Among these theories, the Ostwald-Freundlich equation is specific to nanonization as opposed to micronization, and has been used widely in the pharmaceutical industry, although it has attracted some controversy and has not as yet been thoroughly proven.…”

Section: Introductionmentioning

confidence: 99%

Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals

Sun¹,

Wang²,

Sui³

et al. 2012

IJN

101

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In this paper work, four naked nanocrystals (size range 80–700 nm) were prepared without any surfactant or polymer using the solvent/nonsolvent method. The effects of particle size on their solubility, dissolution, and oral bioavailability were investigated. Solubility and dissolution testing were performed in three types of dissolution medium, and the studies demonstrated that the equilibrium solubilities of coenzyme Q 10 nanocrystals and bulk drugs were not affected by the dissolution media but the kinetic solubilities were. Kinetic solubility curves and changes in particle size distribution were determined and well explained by the proposed solubilization model for the nanocrystals and bulk drugs. The particle size effect on dissolution was clearly influenced by the diffusion coefficients of the various dissolution media, and the dissolution velocity of coenzyme Q 10 increased as particle size decreased. The bioavailability of coenzyme Q 10 after oral administration in beagle dogs was improved by reducing the particle size. For 700 nm nanocrystals, the AUC 0–48 was 4.4-fold greater than that for the coarse suspensions, but a further decrease in particle size from 700 nm to 120 nm did not contribute to improvement in bioavailability until the particle size was reduced to 80 nm, when bioavailability was increased by 7.3-fold.

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“…27,28 Excess amounts of coarse BCN, BCN-SNS, and physical mixture were added in water and equilibrated in a shaker water bath (HZ-92 1K; Taicang Instrument, Taicang, People's Republic of China) at 37°C for 48 hours. Vials were sealed to avoid loss due to evaporation and shielded from light to prevent any degradation of BCN.…”

Section: Powder X-ray Diffractionmentioning

confidence: 99%