Kinetic studies of the immunopharmacologic effects of NPT 15392 in mice

Florentin, I.; Ellis, Taylor; Davigny, M.; Mathé, G; Hadden, John W.

doi:10.1016/0192-0561(82)90052-2

Cited by 13 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very few studies on the mechanisms for the inhibitory effect of tea catechins on type IV allergy have been reported. The difficulty of such an investigation would be due to the complexity of the type IV allergic response (Florentin et al, 1982). In a typical type IV allergic response mediated by appropriately sensitized lymphocytes, early and predominant mononuclear cell infiltration probably occurs (Dietrich and Hess, 1970;Evans et al, 1971).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Tea Catechins andO-Methylated Derivatives of (−)-Epigallocatechin-3-O-gallate on Mouse Type IV Allergy

Suzuki

Yoshino

Maeda‐Yamamoto

et al. 2000

J. Agric. Food Chem.

117

View full text Add to dashboard Cite

The inhibitory effects of tea catechins, the O-methylated derivatives of (-)-epigallocatechin-3-O-gallate (EGCG), and the polyphenol extracts from tea leaves (Camellia sinensis L.) on oxazolone-induced type IV allergy in male ICR mice were investigated. Four major tea catechins and two O-methylated derivatives, (-)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3' 'Me) and (-)-epigallocatechin-3-O-(4-O-methyl)gallate (EGCG4' 'Me), showed significant inhibitory effects on mouse type IV allergy after a percutaneous administration at a dose of 0.13 mg/ear. Among tea catechins, the compounds including galloyl moieties, such as EGCG and (-)-epicatechin-3-O-gallate (ECG), showed the strongest inhibitory activities on mouse type IV allergy. The inhibitory activities of EGCG3' 'Me and EGCG4' 'Me were higher than that of EGCG at a dose of 0.05 mg/ear. Polyphenol extract from tea leaves of Benihomare cultivar, which includes EGCG3' 'Me, strongly inhibited mouse type IV allergy after percutaneous administration in comparison with that from Yabukita cultivar, which does not include EGCG3' 'Me, at doses of 0.05 and 0.13 mg/ear. EGCG3' 'Me is thought to contribute, at least in part, to the inhibitory ability of Benihomare tea leaves on mouse type IV allergy. EGCG and the polyphenol extracts from Benihomare and Yabukita tea leaves also inhibited mouse type IV allergy by oral administration at 1 h before the sensitization and at 1 h before the challenge with oxazolone. Therefore, daily intake of tea drinks could have potential to prevent type IV allergy.

show abstract

Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Tea Catechins andO-Methylated Derivatives of (−)-Epigallocatechin-3-O-gallate on Mouse Type IV Allergy

Suzuki

Yoshino

Maeda‐Yamamoto

et al. 2000

J. Agric. Food Chem.

117

View full text Add to dashboard Cite

show abstract

“…Having established two different models of stress-induced immunosuppression, experiments were undertaken to evaluate effects of the study drugs. The selected test drug formulations were administered orally to the animals before exposing them to stress as per the principles of pro-host therapy [ 36 ]. As there is no pharmacokinetic data available for plant drugs, it was decided to pre-treat the animals with the drugs to ensure attainment of adequate concentrations at the site before subjecting them to the insult.…”

Section: Discussionmentioning

confidence: 99%

Effects of two formulations containing Phyllanthus emblica and Tinospora cordifolia with and without Ocimum sanctum in immunocompromised mice

Malve

2021

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Background Current pandemic has led us to explore the role of traditional system of medicine to look for formulations that enhance immunity. Objective The obejctive of this experimental study was to evaluate the immunomodulatory effects of two formulations, Tinospora cordifolia (Tc) and Phyllanthus emblica (Pe) with and without coating of Ocimum sanctum (Os). Materials and methods After obtaining Institutional Animal Ethics Committee approval, present experimental study was conducted to evaluate the immunomodulatory effects of plant drug formulations against infection induced in mice subjected to major surgical stress. Hemisplenectomy was selected to induce major stress and the procedure for hemisplenectomy was standardized. A model of secondary fungal infection after hemisplenectomy was established followed by the treatment of mice with plant drugs and controls. They were subjected to hemisplenectomy or sham operation and 10 5 C. albicans were injected intravenously. The therapy continued for next 14 days. Kidneys were isolated to estimate fungal load. Fungal load of the kidneys was estimated on post-operative Day 15. Results The test formulations Tc + Pe and Tc + Pe + Os showed significant reduction in the fungal burden of kidneys as compared to hemisplenectomized control group. However, Tc alone exerted better degree of protection as compared to Tc + Pe and Tc + Pe + Os. Conclusion The formulations, Tc + Pe and Tc + Pe + Os that were developed on the basis of theoretical concepts were not found to be superior to Tc. Though the individual ingredients have been shown to possess immunnostimulant activities, in combination, Pe and Os blunted the effects of Tc. The basis for this drug interaction needs further exploration. Thus, the current experimental study validates immunomodulatory role of Tc. However, the addition of Pe with bhavana of Os does not lead to any augmentation of immunomodulatory activity of Tc. This study also underlines the need to generate data on Ayurveda formulations to understand the rationality of the multi-ingredient Ayurvedic formulations.

show abstract

Prohost Modulation of Immunity by Isoprinosine and NPT 15392

Desimone

Hadden

1987

Antibiosis and Host Immunity

View full text Add to dashboard Cite

Kinetic studies of the immunopharmacologic effects of NPT 15392 in mice

Cited by 13 publications

References 2 publications

Inhibitory Effects of Tea Catechins andO-Methylated Derivatives of (−)-Epigallocatechin-3-O-gallate on Mouse Type IV Allergy

Inhibitory Effects of Tea Catechins andO-Methylated Derivatives of (−)-Epigallocatechin-3-O-gallate on Mouse Type IV Allergy

Effects of two formulations containing Phyllanthus emblica and Tinospora cordifolia with and without Ocimum sanctum in immunocompromised mice

Prohost Modulation of Immunity by Isoprinosine and NPT 15392

Contact Info

Product

Resources

About