Prohost Modulation of Immunity by Isoprinosine and NPT 15392

Desimone, Claudio; Hadden, John W.

doi:10.1007/978-1-4613-1901-6_32

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…It has been suggested that one of the drug components or even the drug complex itself links to the ribosomes of the infected cells, provoking a steric modification of host ribosomal structure, thus providing an advantage to host cellular RNA over viral RNA in the competition for linkage with the ribosomal combining sites [25]. The consequence would be a non-reading or incorrect reading of the viral genome, with incorrect transcription of the viral genetic code [26].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases

Slíva

Pantzartzi²,

Votava³

2019

Adv Ther

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Inosine pranobex (IP), commonly known as inosine acedoben dimepranol, isoprinosine and methisoprinol, has been proven to positively impact the host's immune system, by enhancing T-cell lymphocyte proliferation and activity of natural killer cells, increasing levels of proinflammatory cytokines, and thereby restoring deficient responses in immunosuppressed patients. At the same time, it has been shown that it can affect viral RNA levels and hence inhibit growth of several viruses. Due to its immunomodulatory and antiviral properties, and its safety profile, it has been widely used since 1971 against viral infections and diseases, among which subacute sclerosis panencephalitis, herpes simplex virus, human papilloma virus, human immunodeficiency virus, influenza and acute respiratory infections, cytomegalovirus and Epstein-Barr virus infections.Following an analysis of almost five decades of scientific literature since its original approval, we here summarize in vivo and in vitro studies manifesting the means in which IP impacts the host's immune system. We also provide a synopsis of therapeutic trials in the majority of which IP was found to have a beneficial effect. Lastly, positive results from limited studies, suggesting the putative future use of IP in new therapeutic indications are briefly described. In order to support use of IP against viral infections apart from those already approved, and to establish its use in clinical practice, further welldesigned and executed trials are warranted. Funding: Ewopharma International.

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Section: Mechanism Of Actionmentioning

confidence: 99%

Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases

Slíva

Pantzartzi²,

Votava³

2019

Adv Ther

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“…Previous studies showed that, although the activity of methisoprinol was somewhat limited in comparison with that of typical antiviral drugs, it could exert an activity against many RNA and DNA viruses (5). From an immunopharmacologic point of view, methisopri-no1 augments the immunological events induced by triggering agents, such as antigens, lymphokines, and mitogenic substances; many, although not all, of the activities of this drug could be termed "thymomimetic" (6).…”

Section: Introductionmentioning

confidence: 99%

Influence of methisoprinol (lsoprinosine) on hiv‐infected human lymphocytes: In vitro immunological, virological, and ultrastructural studies

Simone

DeMarco

Arancia

et al. 1989

Clinical Laboratory Analysis

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Methisoprinol (isoprinosine) is a synthetic compound with reported antiviral and immunomodulating properties. Results of the present study showed that methisoprinol at concentrations greater than or equal to 200 micrograms/ml reduces the p24 and gp120 viral antigen expression on the surface of human immunodeficiency virus (HIV)-infected lymphocytes and the reverse transcriptase levels. In addition, cell viability, the number of the CD4+ cells, and the CD4+/CD8+ cell ratio are higher in methisoprinol-pretreated cell suspensions than in untreated HIV-infected cell cultures. A quantitative freeze-fracture study on the density of the intramembranous particles (IMP) present on both fracture faces of the plasma membrane of lymphocytes has shown that pretreatment with methisoprinol induces a different molecular organization resulting in a nearly three times increase of IMP density.

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Prohost Modulation of Immunity by Isoprinosine and NPT 15392

Cited by 2 publications

References 29 publications

Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases

Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases

Influence of methisoprinol (lsoprinosine) on hiv‐infected human lymphocytes: In vitro immunological, virological, and ultrastructural studies

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