Kinetic study of the inhibition of ionic liquids on the trypsin activity

Fan, Yunchang; Wang, Xin; Li, Jing; Zhang, Lina; Yang, Lei; Gao, Peng-Fu; Zhou, Zhulin

doi:10.1016/j.molliq.2018.01.014

Cited by 18 publications

(2 citation statements)

References 55 publications

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“…Fan et al [38] reported that the inactivation induced by ILs is consistent with reversible, competitive inhibition after investigating the kinetics of trypsin inhibition by various imidazolium-and ammonium-based ILs. After removing the IL, the enzyme can recover its activity ( Figure 2).…”

Section: Current Developments In Enzymatic Reactions In Ilsmentioning

confidence: 96%

Facilitating enzymatic reactions by using ionic liquids: A mini review

Elgharbawy

Moniruzzaman

Goto

2021

Current Opinion in Green and Sustainable Chemistry

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Over the past two decades, ionic liquids (ILs) have been widely used for enzymatic conversions of substratesespecially substrates that are insoluble in common organic solvents and waterresulting in high conversion rates, high selectivity, and improved enzyme stability, wherein the ILs are recoverable and recyclable. Compared with performance in first-generation ILs, researchers recently considerably improved the technological utility of enzymes in second-and third-generation ILs composed of enzyme-benign cations and anions. Use of upgraded ILs with enzymes offers further improved activity and stability compared with research studies in the past decade, rendering IL-assisted biocatalytic processes more environmentally and economically attractive. This short review briefly presents recent developments of enzymatic reactions in ILs. The review covers approaches for and modifications of enzymes and ILs within the past 2 years for improved enzymes performance in ILs.

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Section: Current Developments In Enzymatic Reactions In Ilsmentioning

confidence: 96%

Facilitating enzymatic reactions by using ionic liquids: A mini review

Elgharbawy

Moniruzzaman

Goto

2021

Current Opinion in Green and Sustainable Chemistry

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“…In recent years, ionic liquids (ILs) have been introduced as the solvent in the chemical processes . They have numerous properties, such as nonvolatility, low toxicity, and nonflammability, which increase their applications in catalysis, green chemistry, enzyme and bio‐catalyst, and chemical industries . Moreover, because of the presence of N atom in their structures, some ILs were applied as the solvent for CO 2 capture .…”

Section: Introductionmentioning

confidence: 99%

Theoretical study on ionic liquids based on DBUH⁺: Molecular engineering and hydrogen bond evaluation

Rezaeian

Izadyar

2019

Int J of Quantum Chemistry

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The new generation of the ionic liquids (ILs) based on 1,8-diazobicylo [5,4,0] undec-7-ene (DBU) are applied as the solvent in organic reactions. In this work, by using a theoretical procedure, the most probable interactions between the ion pairs of DBUH + based ILs, including 10 functionalized imidazole anions were investigated. For this purpose, the electrostatic potential surfaces were analyzed to detect the most probable interaction sites of DBUH + . On the basis of the obtained results, hydrogen bond formation between the anions and DBUH + is influenced by the electronic effect of the substituted functional groups. This means that electron donating groups, such as phenyl has a stabilizing effect on the ion pairs, while electronwithdrawing groups, such as nitro, induces a destabilizing effect. These behaviors are described based on the interaction energy values (ΔE int ). To investigate the dispersion interaction effects in ILs formation, M06-2X-D3 functional was applied in energy analysis. The solvent reaction field was investigated by the polarizable continuum model in ethanol and chloroform as the solvent. The results showed that ethanol has a greater effect on the interaction energy of the ILs. Finally, to have a comprehensive understanding of the charge transfer effect on the stability of the studied ILs and to characterize the most probable interactions, natural bond orbital and quantum theory of atoms in molecules analyses were applied and the obtained results were analyzed. K E Y W O R D S dispersion energy, hydrogen bond, imidazole, ionic liquid

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