Kinetics and Longevity of Antibody Response to Influenza A H5N1 Virus Infection in Humans

Kitphati, Rungrueng; Pooruk, Phisanu; Lerdsamran, Hatairat; Poosuwan, Siriwan; Louisirirotchanakul, Suda; Auewarakul, Prasert; Chokphaibulkit, Kulkanya; Noisumdaeng, Pirom; Sawanpanyalert, Pathom; Puthavathana, Pilaipan

doi:10.1128/cvi.00062-09

Cited by 43 publications

(44 citation statements)

References 10 publications

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“…[21][22][23][24] Looking at the kinetics of immune responses from a different angle, antibody responses to influenza A H5N1 virus infection in fatal cases and survivors showed that high neutralizing antibody titers were achieved only 2 to 3 weeks after symptom onset in the majority of H5N1-infected individuals tested. 25 Further, only one out of five patients had a significant antibody response within 5 d after the onset of disease. Infection should be an even stronger antigen challenge than any vaccination, so these data demonstrate that clinically relevant antibody responses are unlikely to occur within the first 7 d.…”

Section: Discussionmentioning

confidence: 99%

A randomized, placebo-controlled phase I study assessing the safety and immunogenicity of aPseudomonas aeruginosahybrid outer membrane protein OprF/I vaccine (IC43) in healthy volunteers

Westritschnig

Hochreiter

Wallner

et al. 2013

Human Vaccines & Immunotherapeutics

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Section: Discussionmentioning

confidence: 99%

A randomized, placebo-controlled phase I study assessing the safety and immunogenicity of aPseudomonas aeruginosahybrid outer membrane protein OprF/I vaccine (IC43) in healthy volunteers

Westritschnig

Hochreiter

Wallner

et al. 2013

Human Vaccines & Immunotherapeutics

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“…Pada saat gejala dini pada umumnya dokter lebih sering menduga penyakit lain yang lebih sering terjadi seperti infeksi dengue. 25 Rapid diagnostic test untuk influenza memiliki sensitivitas rendah untuk dapat mendeteksi H5N1, sehingga adanya gejala klinis dan riwayat pajanan lebih membantu mengindentifikasi infeksi virus H5N1. 27 Mayoritas kasus bepergian ke atau tinggal di area terinfeksi (72,97%), keadaan ini sangat berisiko bagi anak untuk terjadinya kontak baik secara langsung maupun tidak langsung dengan sumber infeksi.…”

Section: Pembahasanunclassified

Karakteristik Klinis dan Epidemiologis Avian Influenza A (H5N1) Anak Di Indonesia, Tahun 2005-2007

Murniati¹,

Giriputro²,

Hadinegoro³

2016

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Latar belakang. Indonesia merupakan negara tertinggi di dunia yang melaporkan kasus avian influenza A(H5N1) dengan proporsi kematian yang tinggi (83%). Sampai saat ini belum banyak penelitian kasus avian influenza A(H5N1) anak di Indonesia. Tujuan. Mengetahui pola epidemiologis, klinis, laboratoris, dan radiologis dalam hubungannya dengan kesembuhan atau kematian kasus avian influenza A (H5N1) anak. Metode. Studi retrospektif dari 37 kasus konfirmasi avian influenza anak di Indonesia berdasarkan data Badan Litbangkes dan Dirjen P2PL, Depkes RI serta WHO Indonesia dan disajikan secara deskriptif. Hasil. Riwayat kontak secara langsung dan tidak langsung dengan unggas (37,84%) sebanding dengan kontak pada kasus konfirmasi avian influenza (35,14%), 12 kasus diantaranya merupakan anggota kluster keluarga. Kasus terbanyak pada kelompok umur 5-<12 tahun (50,62%). Domisili kasus anak terutama di tiga propinsi Indonesia yaitu DKI Jakarta, Jawa Barat dan Banten. Proporsi kematian avian influenza anak Indonesia lebih rendah (67,57%) dibanding proporsi kematian nasional (82,8%) tetapi masih sedikit lebih tinggi dari proporsi kematian global (59,45%). Gejala klinis utama yaitu demam (100%), batuk (86,49%), sesak (81,08%), serta penurunan kesadaran (62,16%). Pneumonia terjadi pada 59,46% kasus dengan proporsi kematian 68,18%. Kelompok yang mendapat oseltamivir (37%) mempunyai peluang hidup lebih besar dari pada kelompok yang tidak mendapat oseltamivir (20%), demikian pula lama awitan sakit dan dosis awal oseltamivir pada kelompok nonfatal lebih pendek (median 5,5 hari dengan rentang waktu 2-10 hari) dibanding kelompok yang fatal (median 8,5 hari, rentang 3-22 hari) menunjukkan makin cepat mendapat terapi oseltamivir memberi peluang hidup lebih baik. Kesimpulan. Spektrum klinis avian influenza yang luas menempatkan penyakit ini sebagai diagnosis banding yang perlu dipertimbangkan termasuk kematian yang tidak jelas penyakitnya pada kluster keluarga atau sakit berat lainnya. Terapi oseltamivir memberi peluang hidup lebih baik disamping penemuan kasus dini serta perawatan secepatnya. Sari Pediatri 2011;12(5):347-58.Kata kunci: human avian influenza, anak, oseltamivir.

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“…Serum/plasma samples were aliquoted and kept frozen at Ϫ20°C until tested. These samples were previously investigated by HI and microNT assays using KAN-1 virus as the test antigen, and the results were reported (8). Archival serum samples were obtained from 20 H1N1pdm-infected patients with a median age of 20 years (range, 18 to 42 years).…”

Section: Methodsmentioning

confidence: 99%

“…To accomplish this aim, reverse-genetics-derived H4N1 viruses with N1 genomic segments from various origins (rgH4N1 viruses) were constructed and used as test antigens for NI antibody measurement in an enzyme-linked lectin assay (ELLA). (8). This study found that 3 of the H5N1 survivors had mounted an NI antibody response against the homologous and all of the heterologous NAs used (Table 1).…”

mentioning

confidence: 96%

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Kinetics, Longevity, and Cross-Reactivity of Antineuraminidase Antibody after Natural Infection with Influenza A Viruses

Changsom

Jiang

Lerdsamran

et al. 2017

Clin Vaccine Immunol

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The kinetics, longevity, and breadth of antibodies to influenza virus neuraminidase (NA) in archival, sequential serum/plasma samples from influenza A virus (IAV) H5N1 infection survivors and from patients infected with the 2009 pandemic IAV (H1N1) virus were determined using an enzyme-linked lectin-based assay. The reverse-genetics-derived H4N1 viruses harboring a hemagglutinin (HA) segment from A/duck/Shan Tou/461/2000 (H4N9) and an NA segment derived from either IAV H5N1 clade 1, IAV H5N1 clade 2.3.4, the 2009 pandemic IAV (H1N1) (H1N1pdm), or A/Puerto Rico/8/1934 (H1N1) virus were used as the test antigens. These serum/ plasma samples were also investigated by microneutralization (MN) and/or hemagglutination inhibition (HI) assays. Neuraminidase-inhibiting (NI) antibodies against N1 NA of both homologous and heterologous viruses were observed in H5N1 survivors and H1N1pdm patients. H5N1 survivors who were never exposed to H1N1pdm virus developed NI antibodies to H1N1pdm NA. Seroconversion of NI antibodies was observed in 65% of the H1N1pdm patients at day 7 after disease onset, but an increase in titer was not observed in serum samples obtained late in infection. On the other hand, an increase in seroconversion rate with the HI assay was observed in the follow-up series of sera obtained on days 7, 14, 28, and 90 after infection. The study also showed that NI antibodies are broadly reactive, while MN and HI antibodies are more strain specific.

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Kinetics and Longevity of Antibody Response to Influenza A H5N1 Virus Infection in Humans

Cited by 43 publications

References 10 publications

A randomized, placebo-controlled phase I study assessing the safety and immunogenicity of aPseudomonas aeruginosahybrid outer membrane protein OprF/I vaccine (IC43) in healthy volunteers

A randomized, placebo-controlled phase I study assessing the safety and immunogenicity of aPseudomonas aeruginosahybrid outer membrane protein OprF/I vaccine (IC43) in healthy volunteers

Karakteristik Klinis dan Epidemiologis Avian Influenza A (H5N1) Anak Di Indonesia, Tahun 2005-2007

Kinetics, Longevity, and Cross-Reactivity of Antineuraminidase Antibody after Natural Infection with Influenza A Viruses

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