Kinetics and Thermodynamics of Interfacial Transfer

Measurement of liquid-liquid interfacial kinetics

“…The nicotinate kinetics in the C9, C12, and C15 hydrocarbons were also reported by Guy,60 and the temperature dependence of nicotinate systems was reported by Fleming et al. 61 Other systems investigated with the RDC include transfer of KC1 from n-butyl alcohol,65 phenothiazine transfer with bile salts,66 and phenothiazine transfer with different organic phases.67 Amidon et al 53 investigated progesterone transfer with micelles, and Flynn et al56 used the progesterone-transfer system to investigate the effects of viscosity on the boundary-layer thickness in the kinetic measurements.…”

Modeling Kinetics of Subcellular Disposition of Chemicals

“…A further matter of dispute is the interfacial resistance to transfer of chemicals through the phase interface, which is sometimes found to be an effective barrier to the chemical transfer , and, in other cases, turns out to be negligible. , This phenomenon probably is dependent on the ability of transported chemicals to bind to individual bilayer regions (see sections and ), as shown in MD simulations of trans-bilayer transport …”

Thermodynamics of Partitioning of Benzocaine in Some Organic Solvent/Buffer and Liposome Systems.

“…5 that compares the partition coefficients of drug in ROH/W and CH/W to obtain information related to the hydrogen bond contribution to the partitioning of solutes. 36) D log K ROH/W ϭlog K ROH/W Ϫlog K CH/W (5) Equation 5 may be also written as a quotient relationship in the form D log K ROH/W ϭlog(K ROH/W /K CH/W ), showing the hydrogen bond nature of the interactions between the drug and the solvents according to the specific value, that is, if D log K ROH/W Ͼ0, then this result indicates some contribution by hydrogen bond to the partitioning. Table 4 presents the values of the parameter of Seiler and other analogous parameters for BZC at 30°C, calculated from the different parti- Table 2.…”