Kinetics of Cell Adhesion to a Hydrophilic-Hydrophobic Copolymer Model System

Rosen, Jonathan J.; Schway, Michael B.

doi:10.1007/978-1-4613-9786-1_13

Cited by 14 publications

(18 citation statements)

References 7 publications

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“…These materials have shown a great potential in some biomedical applications (such as contact lenses, artificial implants, and drug delivery systems) 7–9. However, cell adhesion to hydrophilic polymers such as poly(hydroxyethyl methacrylate), PHEMA and poly(hydroxyethyl acrylate), PHEA has been reported to be poor 10, 11. The water‐uptake of the system has been controlled by synthesizing random copolymers using hydrophilic and hydrophobic comonomers and, normally, cell response improves as the content of the hydrophobic component does 10, 12.…”

Section: Introductionmentioning

confidence: 99%

“…However, cell adhesion to hydrophilic polymers such as poly(hydroxyethyl methacrylate), PHEMA and poly(hydroxyethyl acrylate), PHEA has been reported to be poor 10, 11. The water‐uptake of the system has been controlled by synthesizing random copolymers using hydrophilic and hydrophobic comonomers and, normally, cell response improves as the content of the hydrophobic component does 10, 12. Even the hydrophilization of polycaprolactone, the well‐known degradable polymer with repeating unit that of the endcapped part of the methacrylate used in this study, has been proposed to improve the cell adhesion 13…”

Section: Introductionmentioning

confidence: 99%

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Structure and properties of methacrylate‐endcapped caprolactone networks with modulated water uptake for biomedical applications

et al. 2007

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Methacrylate-endcapped caprolactone (CLMA) networks were synthesized and copolymerized with 2-hydroxyethyl acrylate (HEA) seeking to tailor the hydrophilicity of the system. The resulting structure of the copolymer network is investigated by differential scanning calorimetry, thermogravimetry, and Fourier transform infrared spectroscopy. The dynamic swelling behavior and the equilibrium water sorption is measured and correlated with the microstructure. The experimental results allow one to conclude that the new material is a random copolymer of both components, HEA and CLMA. The effect of cell attachment and proliferation on the new copolymer networks was observed by in vitro culture of human chondrocytes up to 8 days. Enhanced cellular adhesion, similar to that obtained with tissue culture polystyrene (TCPS), was obtained in the hydrophilized systems. The new copolymers are appropriate for the fabrication of scaffolds with controlled porosity for tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure and properties of methacrylate‐endcapped caprolactone networks with modulated water uptake for biomedical applications

et al. 2007

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“…[28,29] We then measured the static contact angles of the air bubble on the cross-linked membrane-type materials in water. The values measured at 10, 25, and 40 8C are shown in Figure 2.…”

Section: Surface Estimation By Wettability and Xps Measurementmentioning

confidence: 99%

Preparation of Cross‐Linked Poly[(ε‐caprolactone)‐co‐lactide] and Biocompatibility Studies for Tissue Engineering Materials

Miyasako

Yamamoto

Nakao

et al. 2007

Macromolecular Bioscience

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In this study, cross-linked materials were prepared using the branched macromonomer with different CL/LA molar ratios, and feasibility studies for tissue engineering were carried out. The thermal and mechanical properties of these materials depended on the CL/LA compositions; however, there was no change in the wettability of each material. The HeLa cells adhesion and growth on the CL-LA7030c were equal to that on the commercially available polystyrene dish. The protein absorption experiment using the FBS proteins revealed that the materials with well-grown cells showed better adhesion of the proteins. [photo: see text]

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“…Scaffolds made of a combination of hydrophobic and hydrophilic materials seem to be more suitable in cell culture [32][33][34][35][36]. Hydrophobic groups improve cell anchor and hydrophilic groups make easier water diffusion.…”

Section: Porous Polymersmentioning

confidence: 99%

Synthesis and characterisation of macroporous poly(methyl methacrylate) with plasma-polymerised hydrophilic coating

Serrano‐Aroca¹

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Kinetics of Cell Adhesion to a Hydrophilic-Hydrophobic Copolymer Model System

Cited by 14 publications

References 7 publications

Structure and properties of methacrylate‐endcapped caprolactone networks with modulated water uptake for biomedical applications

Structure and properties of methacrylate‐endcapped caprolactone networks with modulated water uptake for biomedical applications

Preparation of Cross‐Linked Poly[(ε‐caprolactone)‐co‐lactide] and Biocompatibility Studies for Tissue Engineering Materials

Synthesis and characterisation of macroporous poly(methyl methacrylate) with plasma-polymerised hydrophilic coating

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