2019
DOI: 10.1128/aem.00438-19
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Kinetics of Enzymatic Mercury Methylation at Nanomolar Concentrations Catalyzed by HgcAB

Abstract: Methylmercury (MeHg) is a potent bioaccumulative neurotoxin that is produced by certain anaerobic bacteria and archaea. Mercury (Hg) methylation has been linked to the gene pair hgcAB, which encodes a membrane-associated corrinoid protein and a ferredoxin. Although microbial Hg methylation has been characterized in vivo, the cellular biochemistry and the specific roles of the gene products HgcA and HgcB in Hg methylation are not well understood. Here, we report the kinetics of Hg methylation in cell lysates of… Show more

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Cited by 27 publications
(18 citation statements)
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“…The coordination of Hg to 3 Cys residues of HgcB could itself contribute to our observation of a possible Hg-S 3 species, although the reported abundance of HgcAB in cells is very low. 55,56 The hgcAB gene cluster responsible for MeHg production is expressed constitutively and is not responsive to Hg. 57 Therefore, Hg biouptake to the cytosol so that Hg reaches the HgcAB active sites is likely the foremost cause for Hgmethylation.…”
Section: (B)mentioning
confidence: 99%
“…The coordination of Hg to 3 Cys residues of HgcB could itself contribute to our observation of a possible Hg-S 3 species, although the reported abundance of HgcAB in cells is very low. 55,56 The hgcAB gene cluster responsible for MeHg production is expressed constitutively and is not responsive to Hg. 57 Therefore, Hg biouptake to the cytosol so that Hg reaches the HgcAB active sites is likely the foremost cause for Hgmethylation.…”
Section: (B)mentioning
confidence: 99%
“…Additionally, as a consequence of processes such as chlor-alkali and gold mining add mercury into the nature. In addition, the inorganic mercury pollutants possess capability to absorb and transform into organic ones by bacteria and microbes [8][9][10][11][12]. The most abundant and stable forms of mercury present in nature, are in its +2 oxidation state.…”
Section: Introductionmentioning
confidence: 99%
“…The gene products of the HgcAB gene cluster catalyze the methylation of mercury by a variety of anaerobic microbes. Date et al (2019) provided an important study of the kinetics of mercury methylation by Desulfovibrio desulfuricans HgcAB.…”
Section: Bacteriamentioning
confidence: 99%