Kinetics of estimated human muscle capillary blood flow during recovery from exercise

Ferreira, Leonardo F.; Harper, Allison J.; Townsend, Dana K.; Lutjemeier, Barbara J.; Barstow, Thomas J.

doi:10.1113/expphysiol.2005.030189

Cited by 45 publications

(64 citation statements)

References 56 publications

(150 reference statements)

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“…Nevertheless, it is important to note that our data support the notion that both INT exercise protocols display similar increased O 2 delivery conditions as has been observed within the light-intensity knee-extension exercise domain (Lutjemeier et al 2005). Moreover, Ferreira et al (2005a) showed that the drop in muscle capillary blood flow is larger upon the immediate cessation of moderate-intensity compared to light-intensity cycling and suggested that the removal of the muscle pump was responsible for this decline. In light of this, the inclusion of the moderate work rate during the recovery of INT 2 may increase the muscle pump effect and account for the decrease in DHHb/VO 2 during INT2 compared to INT1.…”

Section: Improved Blood Flow Distribution During Int 2 Versus Intsupporting

confidence: 84%

“…Our data suggest that the increase in power output of the recovery period of INT 2 is accompanied by greater oxidative phosphorylation contribution during the 10 s work period to meet the energy demands. The elevated VO 2 during INT2 may be associated with the speeding of VO 2 kinetics over the recovery work transition compared to INT 1, as a function of the improved blood flow distribution at the onset of the work period that has been observed elsewhere (DiMenna et al 2010;Ferreira et al 2005aFerreira et al , 2005bFerreira et al , 2006Ferreira et al , 2005cFerreira et al , 2005dHarper et al 2006;Hughson et al 1996). In particular, Grassi et al (2000) observed an *25% speeding in VO 2 kinetics at the onset of a highintensity exercise in a model in which blood flow was elevated before the onset of exercise to meet the O 2 requirements expected during an abrupt transition to highintensity exercise.…”

Section: Improved Blood Flow Distribution During Int 2 Versus Intmentioning

confidence: 95%

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The effects of short recovery duration on VO2 and muscle deoxygenation during intermittent exercise

et al. 2011

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This study compared the oxygen uptake (VO(2)) and muscle deoxygenation (∆HHb) of two intermittent protocols to responses during continuous constant load cycle exercise in males (24 year ± 2, n = 7). Subjects performed three protocols: (1) 10 s work/5 s active recovery (R), R at 20 W (INT1): (2) 10 s work/5 s R, R at moderate intensity (INT2); and (3) continuous exercise (CONT), all for 10 min, on separate days. The work rate of CONT and the 10 s work of INT1 and INT2 were set within the heavy intensity domain. VO(2) and ∆HHb data were filtered and averaged to 5 s bins. Average VO(2) (80-420 s) was highest during CONT (3.77 L/min), lower in INT2 (3.04 L/min), and lowest during INT1 (2.81 L/min), all (p < 0.05). Average ∆HHb (80-420 s) was higher during CONT (p < 0.05) than both INT exercise protocols (CONT; 25.7 ± 0.9 a.u. INT1; 16.4 ± 0.8 a.u., and INT2; 15.8 ± 0.8 a.u.). The repeated changes in metabolic rate elicited oscillations in ΔHHb in both intermittent protocols, whereas oscillations in VO(2) were only observed during INT1. The greater ΔHHb during CONT suggests a reduction in oxygen delivery compared to oxygen consumption relative to INT. The higher VO(2) for INT 2 versus INT 1 and similar ΔHHb during INT suggests an increase in oxygen delivery during INT 2. Thus the different demands of INT1, INT2, and CONT protocols elicited differing physiological responses to a similar heavy intensity power output. These intermittent exercise models seem to elicit an elevated O(2) delivery condition compared to CONT.

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Section: Improved Blood Flow Distribution During Int 2 Versus Intsupporting

confidence: 84%

Section: Improved Blood Flow Distribution During Int 2 Versus Intmentioning

confidence: 95%

The effects of short recovery duration on VO2 and muscle deoxygenation during intermittent exercise

et al. 2011

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“…Therefore HHb kinetics are considered a more accurate marker of muscle tissue oxygenation than O 2 Hb kinetics [23,26,27]. As demonstrated by Ferreira et al [5], HHb recovery kinetics following submaximal exercise can be adequately assessed by the mean response time (i.e. time delay+time constant of mono-exponential decrease), approximating the time to reach 63 % of the response.…”

Section: Nirsmentioning

confidence: 98%

“…Whereas O 2 delivery is determined by muscle blood flow and arterial O 2 content, O 2 utilization is associated with oxidative capacity of skeletal muscles. Studies in healthy untrained individuals have provided evidence that metabolic recovery is limited by O 2 utilization, rather than O 2 delivery [5][6][7]. In CHF patients, both impairments in muscle blood flow [8,9] and muscle oxidative capacity [10,11] have been documented.…”

Section: Introductionmentioning

confidence: 97%

Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O2 delivery than O2 utilization

et al. 2010

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CHF (chronic heart failure) is associated with a prolonged recovery of skeletal muscle energy stores following submaximal exercise, limiting the ability to perform repetitive daily activities.However, the pathophysiological background of this impairment is not well established. The aim of the present study was to investigate whether muscle metabolic recovery following submaximal exercise in patients with CHF is limited by O2 delivery or O2 utilization. A total of 13 stable CHF patients (New York Heart Association classes II-III) and eight healthy subjects, matched for age and BMI (body mass index), were included. All subjects performed repetitive submaximal dynamic single leg extensions in the supine position. Post-exercise PCr (phosphocreatine) resynthesis was assessed by 31P-MRS (magnetic resonance spectroscopy). NIRS (near-IR spectroscopy) was applied simultaneously, using the rate of decrease in HHb (deoxygenated haemoglobin) as an index of post-exercise muscle re-oxygenation. As expected, PCr recovery was slower in CHF patients than in control subjects (time constant, 47+/-10 compared with 35+/-12 s respectively; P=0.04). HHb recovery kinetics were also prolonged in CHF patients (mean response time, 74+/-41 compared with 44+/-17 s respectively; P=0.04). In the patient group, HHb recovery kinetics were slower than PCr recovery kinetics (P=0.02), whereas no difference existed in the control group(P=0.32). In conclusion, prolonged metabolic recovery in CHF patients is associated with an even slower muscle tissue re-oxygenation, indicating a lower O(2) delivery relative to metabolic demands. Therefore we postulate that the impaired ability to perform repetitive daily activities in these patients depends more on a reduced muscle blood flow than on limitations in O(2) utilization.

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“…Such investigations require the ability to follow the dynamics of V O 2 and Q o 2 in separatum, the latter of which has proven more challenging. However, inferences regarding Q o 2 at the level of the microvasculature have been performed using near infrared spectroscopy in conjunction with pulmonary measures of V O 2 to approximate muscle V O 2 during the transition from rest to steady-state exercise and during ramp exercise protocols (7,8). Although each of these approaches have their own set of caveats, such techniques may prove useful in providing further insight to the centrally mediated peripheral dysfunction in CHF and other diseases.…”

mentioning

confidence: 99%

Integrative research: the key to unlocking the mysteries of chronic heart failure and skeletal muscle dysfunction

Trinity

Richardson

2010

American Journal of Physiology-Heart and Circulatory Physiology

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REDUCTIONS IN EXERCISE CAPACITY in patients with chronic heart failure (CHF) were originally linked solely to central limitations associated with a malfunctioning cardiac pump. However, over the last 20 years, peripheral factors related to skeletal muscle and the vascular/skeletal muscle interface have been implicated in this phenomenon. Specifically, muscle atrophy, fiber-type alterations, reduced mitochondrial enzymes, decreased mitochondrial volume density, and decreased capillarity (3,4,9,(12)(13)(14)22) have gained attention since these changes have been associated with CHF. Most certainly, the central and peripheral alterations are intimately linked, requiring an integrative approach to understanding the limitations and mechanisms responsible for the diminished work capacity in this patient population.In this issue of the American Journal of Physiology-Heart and Circulatory Physiology, Copp et al.(1) employed an integrative approach to examine peripheral dysfunction in CHF as measured by the off-transient or recovery kinetics of microvascular O 2 pressure (Pmv O 2 ) and coupled this peripheral measure with central hemodynamic and morphological indexes of heart failure. The most novel and important findings of this study were that 1) progressive CHF increasingly slowed the recovery of Pmv O 2 in a mixed fiber-type muscle, 2) mean response time of the off-transient (MRT off ) and the MRT off-on differences (a measure of the asymmetry between on-and off-transients) correlated with central hemodynamic and morphological indexes of heart failure, and 3) off-transient differences may be present despite a lack of on-transient alterations. A recognized limitation of this study is the finding that the correlations of off-transient and central indexes of cardiac failure were likely driven by the inclusion of four animals with the most severe heart failure; this group could be increased in number to solidify these conclusions. Despite this concern regarding the relatively small cohort of severe CHF in the study of Copp et al. (1), these findings have potential importance in terms of functional capacity and may provide insight into why work and exercise tolerance as well as the ability to perform activities of daily living are reduced in patients with CHF.The technique of phosphorescence quenching (20), as used by Copp et al. (1), allowed the direct determination of Pmv O 2 during the transition from exercise to rest in the muscle of mixed fiber type (spinotrapezius). The spinotrapezius was chosen since the muscle fiber-type composition and oxidative capacity are similar to the human quadriceps (21), thereby making this model a relevant and potentially translational animal model. Pmv O 2 is determined by the relationship of delivery and uptake of O 2 (Q o 2 to V O 2 ), which in turn facilitates blood-to-tissue O 2 flux and has an impact on the regulation of cellular metabolism (6,15,17 (1), in the muscle of rats with CHF likely interferes with the ability to recover from muscular contractions, thereby accelerating fati...

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Kinetics of estimated human muscle capillary blood flow during recovery from exercise

Cited by 45 publications

References 56 publications

The effects of short recovery duration on VO2 and muscle deoxygenation during intermittent exercise

The effects of short recovery duration on VO2 and muscle deoxygenation during intermittent exercise

Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O2 delivery than O2 utilization

Integrative research: the key to unlocking the mysteries of chronic heart failure and skeletal muscle dysfunction

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