2010
DOI: 10.1042/cs20090220
|View full text |Cite
|
Sign up to set email alerts
|

Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O2 delivery than O2 utilization

Abstract: CHF (chronic heart failure) is associated with a prolonged recovery of skeletal muscle energy stores following submaximal exercise, limiting the ability to perform repetitive daily activities.However, the pathophysiological background of this impairment is not well established. The aim of the present study was to investigate whether muscle metabolic recovery following submaximal exercise in patients with CHF is limited by O2 delivery or O2 utilization. A total of 13 stable CHF patients (New York Heart Associat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

2
25
0

Year Published

2010
2010
2016
2016

Publication Types

Select...
5
4

Relationship

1
8

Authors

Journals

citations
Cited by 38 publications
(27 citation statements)
references
References 41 publications
2
25
0
Order By: Relevance
“…5), it does not provide clear insights into tissue that is more representative of human locomotor muscle(s). The present observation that progressive CHF slows the increase in Pmv O 2 during the recovery from contractions in the mixed fiber-type spinotrapezius muscle is consistent with the slowed pulmonary V O 2 (8,9,45), skeletal muscle oxygenation (8,17,24), and PCr (9,24,37,48) recovery kinetics after exercise in CHF patients. The Pmv O 2 asymmetry between the on-and off-transients (MRT off-on ) evident for all groups in the present investigation was expected based on similar observations in young healthy (33), aged (19), and slow-twitch CHF (34) muscle.…”
Section: Discussionsupporting
confidence: 84%
“…5), it does not provide clear insights into tissue that is more representative of human locomotor muscle(s). The present observation that progressive CHF slows the increase in Pmv O 2 during the recovery from contractions in the mixed fiber-type spinotrapezius muscle is consistent with the slowed pulmonary V O 2 (8,9,45), skeletal muscle oxygenation (8,17,24), and PCr (9,24,37,48) recovery kinetics after exercise in CHF patients. The Pmv O 2 asymmetry between the on-and off-transients (MRT off-on ) evident for all groups in the present investigation was expected based on similar observations in young healthy (33), aged (19), and slow-twitch CHF (34) muscle.…”
Section: Discussionsupporting
confidence: 84%
“…Changes in mitochondrial function have been associated with several disorders, including diabetes [21] and chronic heart failure [22]. In vivo mitochondrial capacity in these patients is quantified by the PCr recovery method [23]. In addition, often, muscle biopsy samples are obtained to determine whether a prolonged PCr recovery period is a result of a decreased number of mitochondria or intrinsic mitochondrial dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…NIRS was introduced in the 1970s by Jöbsis2 to study cerebral and myocardial blood flow. The technique is currently used in clinical testing to investigate muscle,3 breast tumors,4, 5 cerebral tissue,6, 7 peripheral and cerebrovascular disease,8, 9 and congestive heart failure 10. The advantages of the NIRS technique are its non‐invasiveness, ease of application, and low signal–noise during exercise.…”
Section: Discussionmentioning
confidence: 99%