Kinetics of Ischemia-Modified Albumin Following Exercise-Induced Myocardial Ischemia

Bakula, Miro; Miličević, Goran; Bakula, Maja; Kožić, Irena; Rumenjak, Vlatko; Dominković, Anto

doi:10.7754/clin.lab.2015.150732

Cited by 6 publications

(7 citation statements)

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“…The lack of significant higher IMA levels after ultra marathon distance vs. pre-race vales could be explained by the presence of other mechanisms responsible for training-induced cardio protection include increased shock proteins levels or increased myocardial antioxidant capacity in elite endurance trained athletes. Previous studies reported IMA is an early marker of myocardial ischemia in the diagnosis of coronary artery disease [28,41]. It was revealed that IMA levels may increase during myocardial ischemia as seen during strenuous exercise [27].…”

Section: Discussionmentioning

confidence: 99%

“…Further, several studies used conventional biomarkers such as creatine kinase myocardial band (CKMB) and cardiac specific troponin (cTnT) associated with hypoxia-induced myocardial injury [20,24,25,26]. However, the importance of the use ischemia modified albumin (IMA) and heart-type fatty acid binding protein (H-FABP) measurements as new markers to detect or exclude an early-stage myocardial ischemia has also been available [27,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

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Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon

Żebrowska¹,

Waśkiewicz

Nikolaidis

et al. 2019

JCM

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The aim of the present study was to examine the acute effect of an ultra-endurance performance on N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac specific troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), high sensitive C-reactive protein (hsCRP), ischemia modified albumin (IMA), heart-type fatty acid binding protein (H-FABP) and cardiovascular function. Cardiac biomarkers were evaluated in 14 male ultra-marathoners (age 40 ± 12 years) during a 24 h ultra-marathon at five points (i.e., Pre-race; Marathon, 12-h run, 24-h run, and 48-h post-race). All subjects underwent baseline echocardiography assessment at least 10 days prior to the ultra-marathon and 48 h post-race. The average distance covered during the race was 149.4 ± 33.0 km. Running the ultra-marathon led to a progressive increase in hsCRP and H-FABP concentrations (p < 0.001). CK-MB and cTnT levels were higher after a 24-h run compared to pre-race (p < 0.05). Diastolic function was altered post-race characterized by a reduction in peak early to late diastolic filling (p < 0.01). Running an ultra-marathon significantly stimulates specific cardiac biomarkers; however, the dynamic of secretion of biomarkers linked to myocardium ischemia were differentially regulated during the ultra-marathon race. It is suggested that both exercise duration and intensity play a crucial role in cardiovascular adaptive mechanisms and cause risk of cardiac stress in ultra-marathoners.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon

Żebrowska¹,

Waśkiewicz

Nikolaidis

et al. 2019

JCM

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“…Moreover, due to this altered structure of the endothelium as well as due to hyper production of pro-inflammatory molecules, the capillary permeability is increased. Aggressive production of proinflammatory cytokines is because of the special biochemical interactions between the lipopolysaccharides-binding protein (LBP) and its receptor CD14, situated on the surface of macrophages (Hafizi et al 2012;Luan et al 2015;Ranji et al 2015;Bakula et al 2016;Boursier et al 2016). From the point of view of molecular expression of the pro-inflammatory cells, in the literature it is clearly mentioned that there is an excessive rise in few series of interleukins, like interleukin 1 (IL-1), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 12 (IL-12), interleukin 17 (IL-17), interleukin 13 (IL-13) and interleukin 10 (IL-10) (Daniel Trancȃ et al 2014;Singer 2014;Dumache et al 2015).…”

Section: Pathophysiology Of Sepsismentioning

confidence: 99%

The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs

Păpurică¹,

Rogobete²,

Săndesc³

et al. 2016

Biochem Genet

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Critical polytrauma patients present a series of pathophysiological disturbances, biochemical and molecular dysfunction, which comprise to be the major cause of intensive care unit admission. In regard to molecular damage, there exists a series of factors, which all together contribute to the aggravation of the clinical status leading to increased mortality rate in these patients. One of the most important biochemical factors involved is the nuclear transcription factor B (NF-κB). Impaired NF-κB functioning is reflected on the clinical status of the patient through increased production of pro-inflammatory molecule, leading to multiple organ dysfunction syndrome. In addition to this, through microRNAs interactions, various pathophysiological as well as biochemical disturbances are produced, which altogether further reduce the patient's survival rate. In this paper, we would like to present the modifications seen in the expression of NF-κB in critically polytraumatized patients with sepsis. In additions to this, we would like to discuss the correlation between the microRNAs and its further implications in clinical status of these patients.

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“…CuSO 4 exposure significantly increased the plasma levels of inflammatory cytokines, including IMA, hFABP, cTn-I, and BNP, which are strongly associated with increased risks of myocardial injury and ischemia. It is well known that IMA has been evaluated as a potential biomarker of early myocardial ischemia in clinical models of heart injury recognized by the United States Food and Drug Administration [ 34 , 35 ]; hFABP is a specific biomarker and immediately functions as a myocardial fatty acid transporter when myocardial injury occurs [ 36 ]; cTn-I, a specific contractile protein on the myocardial fibers, is a non-enzymatic serum marker for detecting myocardial injury with high specificity and sensitivity [ 37 ]; and BNP is a validated risk marker in cardiac diseases and can provide a remarkable guidance in cardiovascular complications prediction [ 38 ]; HO-1, a crucial part of the Nrf2/HO-1 signaling pathway, plays a physiological role through its anti-inflammatory and anti-oxidant actions [ 19 , 39 ]. In previous studies, HO-1 up-regulation decreased myocardial ischemia-reperfusion injury and effectively promoted the recovery of cardiac function through the activation of the Nrf2/HO-1 pathway [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Gandouling Mitigates CuSO4-Induced Heart Injury in Rats

Fang

Yang

Zhang

et al. 2022

Animals

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We assessed the protective effects of Gandouling (GDL) on copper sulfate (CuSO4)-induced heart injuries in Sprague–Dawley rats, which were randomly divided into the control, CuSO4, GDL + CuSO4 and penicillamine + CuSO4 groups. The rats received intragastric GDL (400 mg/kg body weight) once per day for 42 consecutive days after 56 days of CuSO4 exposure, and penicillamine was used as a positive control. The levels of plasma inflammatory cytokines (IMA, hFABP, cTn-I and BNP) were determined using the enzyme-linked immunosorbent assay. The histopathological symptoms were evaluated using hematoxylin and eosin staining and transmission electron microscopy. To determine the underlying mechanism, Western blotting was conducted for the detection of the heme oxygenase 1 (HO-1) expression. The results revealed that GDL supplementation alleviated the histopathological symptoms of the rat heart tissue, promoted Cu excretion to attenuate impairment, and significantly decreased inflammatory cytokine levels in the plasma (p < 0.01). In addition, GDL increased the HO-1 expression in the rat hepatic tissue. The protective effect of GDL on the heart was superior to that of penicillamine. Overall, these findings indicate that GDL alleviates hepatic heart injury after a Cu overaccumulation challenge, and GDL supplements can be beneficial for patients with Wilson’s disease.

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Kinetics of Ischemia-Modified Albumin Following Exercise-Induced Myocardial Ischemia

Cited by 6 publications

References 0 publications

Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon

Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon

The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs

Gandouling Mitigates CuSO4-Induced Heart Injury in Rats

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