Kinetics of Plasma Cytokines, Angiopoietin-2, and C-Reactive Protein in Dogs With Gastric Dilatation Volvulus

Brunner, Anna; Schüller, Simone; Hettlich, Bianca Felicitas; Marti, Eliane; Lehmann, Anna; Peters, Laureen M.; Adamik, Katja‐Nicole

doi:10.3389/fvets.2021.652479

Cited by 5 publications

(19 citation statements)

References 51 publications

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“…Exclusion criteria were known history of kidney disease and administration of nephrotoxic drugs (such as non-steroidal analgesic drugs) within 14 days before inclusion in the study. Some data from the dogs in the non-lidocaine group were used in a previous study (9). Additionally, 18 healthy dogs, which were part of a previous study, served as a healthy control group for pCr, uNGAL and UNCR (23).…”

Section: Subjectsmentioning

confidence: 99%

“…All GDV dogs underwent standardized stabilization, anesthesia, surgery, and post-operative monitoring as described in a previous study by the same institution (9). For cardiovascular stabilization, supplemental oxygen and IV isotonic balanced and buffered crystalloids (Plasma-Lyte A R , Baxter AG, Switzerland) was administered at the clinician's discretion.…”

Section: Interventions General Treatment Protocolmentioning

confidence: 99%

“…No significant difference in concentrations of pCr and pNGAL was found between the healthy control group and GDV dogs at T 0 (Table 3). At T 1 , dogs with GDV had significantly lower pCr and Mentation score (28): 0, Normal; 1, able to stand unassisted, responsive but dull; 2, can stand only when assisted, responsive but dull; 3, unable to stand, responsive; 4, unable to stand, unresponsive; SBP, systolic blood pressure assessed with oscillometry (SunTech R Vet20 TM blood pressure monitor, Morrisville, NC, USA); t clinicals signs, duration of clinical signs prior to fluid therapy in minutes; t T0-surgery; duration of time between admission and surgery in minutes; gastric wall changes according to reference (9).…”

Section: Plasmatic Renal Biomarkersmentioning

confidence: 99%

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Concentrations and kinetics of renal biomarkers in dogs with gastric dilatation-volvulus with and without 24-h intravenous lidocaine

et al. 2023

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BackgroundGastric dilatation volvulus (GDV) can lead to organ failure including acute kidney injury (AKI). Due to its cytoprotective, antioxidant and anti-inflammatory effects, lidocaine has a potential to prevent AKI in dogs with GDV.Design and settingProspective, observational cohort study in client-owned dogs with GDV.ObjectiveTo determine concentrations of renal biomarkers for AKI in dogs with GDV with and without intravenous (IV) lidocaine therapy.MethodsThirty-two dogs were randomized to receive either IV lidocaine (2 mg/kg, followed by a lidocaine constant rate infusion at a dose of 50 μg/kg/min over 24 h; n = 17) or no lidocaine (n = 15). Blood and urine samples were taken at admission (T0) (only blood), during or immediately after surgery (T1), and 24 (T24) and 48 (T48) h after surgery. Plasma creatinine (pCr), plasma neutrophil gelatinase-associated lipocalin (pNGAL), urinary NGAL (uNGAL), uNGAL to creatinine ratio (UNCR), and urinary gamma-glutamyl transferase to creatinine ratio (uGGT/uCr) were evaluated. Biomarker concentrations were compared between dogs with and without IV lidocaine and the course of each marker was determined in comparison to its admission value.ResultsIn the entire population, a significantly higher pCr at T0 (median, 95 μmol/L, interquartile range, 82–105) compared with T1 (69 μmol/L, 60–78), T24 (63 μmol/L, 52–78), and T48 (78 μmol/L, 65–87) (P < 0.001) was found. Plasma NGAL increased significantly between T0 (5.66 ng/mL, 3.58–7.43) and T24 (7.50 ng/mL, 4.01–11.89) (P = 0.006) and T48 (9.86 ng/mL, 5.52–13.92) (P < 0.001), respectively. Urinary NGAL increased significantly between T1 (0.61 ng/mL, 0.30–2.59) and T24 (2.62 ng/mL, 1.86–10.92) (P = 0.001) and T48 (4.79 ng/mL, 1.96–34.97 (P < 0.001), respectively. UNCR increased significantly between T1 (0.15 μg/mmol, 0.09–0.54) and T24 (1.14 μg/mmol, 0.41–3.58) (P = 0.0015) and T48 (1.34 μg/mmol, 0.30–7.42) (P < 0.001), respectively. Concentrations of uGGT/uCr increased significantly from T0 highest at T24 (6.20 U/mmol, 3.90–9.90) and significantly decreased at T48 (3.76 U/mmol, 2.84–6.22) (P < 0.001). No significant differences in any renal biomarker concentration were found between dogs with and without IV lidocaine therapy.Conclusion and clinical relevancePlasma NGAL, uNGAL and UNCR remained increased up to 48 h post-surgery. No evidence of lidocaine-associated renoprotection was found.

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Section: Subjectsmentioning

confidence: 99%

Section: Interventions General Treatment Protocolmentioning

confidence: 99%

Section: Plasmatic Renal Biomarkersmentioning

confidence: 99%

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Concentrations and kinetics of renal biomarkers in dogs with gastric dilatation-volvulus with and without 24-h intravenous lidocaine

et al. 2023

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“…CRP also dropped to the greatest extent in dogs who died, rather than in survivors. In dogs with gastric dilatation, gastric volvulus and urolithiasis CRP was within the normal range, but other authors report a significant increase in CRP concentration 24 and 48 h after the gastric dilatation-volvulus surgery [ 98 ]. Thus, it may be concluded that CRP increases with the severity of the condition, although the rapid decrease over a short time may carry a negative prognostic value and should be taken into consideration by clinicians as well as researchers.…”

Section: Other Diseasesmentioning

confidence: 99%

C-Reactive Protein as a Diagnostic Marker in Dogs: A Review

Malin

2022

Animals

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Acute phase response is a nonspecific reaction to disturbances in homeostasis during which the production of some Acute Phase Proteins (APPs) is stimulated; they are sensitive but nonspecific markers of systemic inflammatory processes. The major positive APP in dogs is the C-reactive protein (CRP). The dynamic of its concentration changes fast, rising and decreasing rapidly with the onset and removal of the inflammatory stimulus. It increases within the first 4–24 h after the stimulus and reaches up to a 50–100-fold increase of the baseline level. It has been documented that this APP’s concentration is elevated during several diseases, such as pyometra, panniculitis, acute pancreatitis, polyarthritis, sepsis, immune-mediated hemolytic anemia, and neoplasia in dogs. In clinical practice, canine CRP is mostly measured to detect and monitor systemic inflammatory activity and the efficacy of treatments, because it is a more sensitive marker than shifts in leukocyte counts. Blood serum CRP concentration is becoming a part of routine biochemistry panels in many countries. In this article, changes in CRP concentration and its clinical application in healthy and diseased dogs are discussed.

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“…Hepatocytes produce CRP when stimulated by pro‐inflammatory cytokines such as interleukin‐6 (IL‐6), tumour necrosis factor‐alpha (TNF‐α) and interleukin‐1‐beta (IL‐1β) 7 . Within the first 24–48 hours of tissue injury, serum CRP (sCRP) increases in response to stimulus before quickly declining and normalising within 8 days 6–10 . In veterinary medicine, sCRP has been shown to be elevated in numerous conditions, such as pyometra, acute pancreatitis, some neoplasias (such as lymphoma) and immune‐mediated diseases (such as steroid‐responsive meningitis‐arteritis) 5,11–15 …”

Section: Introductionmentioning

confidence: 99%

Serum C‐reactive protein concentrations in dogs with structural and idiopathic epilepsy

Mahon¹,

Williams

Alves

2023

Veterinary Record

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BackgroundC‐reactive protein (CRP) is an acute‐phase protein produced by the liver during systemic inflammation. In humans, some epilepsies are associated with increased serum CRP (sCRP) concentrations, but this has yet to be proven in veterinary studies. Dogs with structural epilepsy (SE) and normal interictal neurological examination are hard to distinguish from dogs with idiopathic epilepsy (IE) without the use of advanced imaging.MethodsThe study included eight dogs with SE and 12 dogs with IE from a referral hospital population. This was a retrospective observational cohort study. The Mann–Whitney test was used to compare the sCRP concentrations within 24 hours of the last epileptic seizure between dogs with SE or IE.ResultsDogs with SE had higher sCRP concentrations than dogs with IE (8.9 [range <2.2–53.2] mg/L vs. <2.2 [range <2.2–6.9] mg/L; p = 0.043). Five of the eight (62%) dogs with SE had an sCRP concentration above the reference interval, compared with none of the 12 dogs with IE.LimitationsThe small sample size was the major limitation of this study. Other inflammatory causes were also not exclusively ruled out, although further clinical investigations were not indicated.ConclusionsThis study found that sCRP concentrations were higher in this cohort of dogs with SE than in those with IE. Further studies with larger cohorts of dogs are warranted to validate if sCRP can be used as an additional biomarker for SE.

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Kinetics of Plasma Cytokines, Angiopoietin-2, and C-Reactive Protein in Dogs With Gastric Dilatation Volvulus

Cited by 5 publications

References 51 publications

Concentrations and kinetics of renal biomarkers in dogs with gastric dilatation-volvulus with and without 24-h intravenous lidocaine

Concentrations and kinetics of renal biomarkers in dogs with gastric dilatation-volvulus with and without 24-h intravenous lidocaine

C-Reactive Protein as a Diagnostic Marker in Dogs: A Review

Serum C‐reactive protein concentrations in dogs with structural and idiopathic epilepsy

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