Kinetics of the Extraction of Succinic Acid with Tri‐<i>n</i>‐octylamine in 1‐Octanol Solution

Jun, Young‐Si; Huh, Yun Suk; Hong, Won Hi; Hong, Yeon Ki

doi:10.1021/bp050083t

Cited by 24 publications

(13 citation statements)

References 25 publications

(47 reference statements)

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“…Most conventional extraction agents show very unfavorable distribution coefficients for organic acids. Reactive extraction is considered to be an effective primary separation step for the recovery of carboxylic acids [118] and long‐chain aliphatic primary, secondary, and tertiary amines have been proposed [119–122]. Reactive extraction with aliphatic amines depends on many factors [123]: if the separation process enables the recycling of costly amines efficiently, then an optimized reactive extraction processes might serve a role in industrial production of bio‐succinic acid, although it is better suited to the processing of higher value compounds.…”

Section: Downstream Processing Factorsmentioning

confidence: 99%

Succinate production in Escherichia coli

Thakker

Martínez

San

et al. 2011

Biotechnology Journal

169

108

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Succinate has been recognized as an important platform chemical that can be produced from biomass. While a number of organisms are capable of succinate production naturally, this review focuses on the engineering of Escherichia coli for production of the four-carbon dicarboxylic acid. Important features of a succinate production system are to achieve optimal balance of reducing equivalents generated by consumption of the feedstock, while maximizing the amount of carbon that is channeled to the product. Aerobic and anaerobic production strains have been developed and applied to production from glucose as well as other abundant carbon sources. Metabolic engineering methods and strain evolution have been used and supplemented by the recent application of systems biology and in silico modeling tools to construct optimal production strains. The metabolic capacity of the production strain, as well as the requirement for efficient recovery of succinate and the reliability of the performance under scale-up are important in the overall process. The costs of the overall biorefinery compatible process will determine the economical commercialization of succinate and its impact in larger chemical markets.

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Section: Downstream Processing Factorsmentioning

confidence: 99%

Succinate production in Escherichia coli

Thakker

Martínez

San

et al. 2011

Biotechnology Journal

169

108

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“…Based on the previous reports, the individual mass transfer coefficients of 3-DMC in the aqueous and organic phase were determined from the diffusion experiments of water and chloroform system [27,28]. The mass transfer coefficients of 3-DMC in the aqueous and organic phase were correlated (Fig.…”

Section: Determination Of Mass Transfer Coefficientsmentioning

confidence: 99%

Enhanced extraction of 3‐demethylated colchicine from fermentation broth of Bacillus megaterium: Optimization of process parameters by statistical experimental design

Dubey¹,

Jawed

Haque

2011

Engineering in Life Sciences

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Biotransformation of colchicine into its pharmacologically active regiospecific derivative 3‐demethylated colchicine (3‐DMC) mediated by microbial monooxygenases is an economic and promising strategy for the production of this inexpensive and potent anti‐cancer drug. Response surface methodology (RSM), with central composite design (CCD) model, was employed with three extraction variables (temperature, pH, and process time) for optimization; which most significantly affected recovery of 3‐DMC. The validity of the model was ascertained by running the predicted values in an individual run; and the optimum parameters, temperature (50°C), pH (10), and process time (120 min) resulted in a maximum recovery of 3‐DMC 4128 mg/L when chloroform (1% v/v) was used as an extraction solvent. RSM in our experiments showed to be a good tool for the extraction of 3‐DMC from the fermentation medium.

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“…Therefore, there is a desire of a highly efficient downstream method for the recovery of the acid after fermentation. Hence, with cumulative prospects of its industrial application, there is an upturn in the requirement of a competent method for the recovery of the pyruvic acid …”

Section: Introductionmentioning

confidence: 99%

Reactive Extraction of Pyruvic Acid Using Tri-n-octylamine Diluted in Decanol/Kerosene: Equilibrium and Effect of Temperature

et al. 2015

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Demand of pyruvic acid is increasing many fold due to its multifarious applications in the food, agro, and chemical industries. Pyruvic acid production through biotechnological methods has emerged as efficient, low cost, and sustainable technology with few challenges at downstream stage (separation and purification). Reactive extraction is gaining attention over other existing method of separation of carboxylic acids from fermentation broth due to its various peculiar advantages like energy efficiency, high yield and selectivity, low cost, and environmental friendliness. In this context, reactive extraction of pyruvic acid (0.03 kmol•m −3 to 0.4 kmol•m −3 ) using tri-n-octylamine (TOA, 0.114 to 0.343 kmol•m −3 ) as an extractant and decanol and kerosene as a diluents has been studied at T = 303 K ± 1 K. The extraction efficiency using only diluent was found inferior to extractant−diluent system. Physical equilibria were interpreted in terms of partition factor (Ψ) and dimerization factor (Φ).Chemical equilibrium was treated according to mass action model and results are presented in terms of distribution coefficient (D C ), loading factor (L r ), and percent extraction (% η). Estimation of equilibrium complexation constant (β e (x,y) ) and complex stoichiometry (x:y) was ascertained by following two different methods. For (TOA + decanol) system, both (1:1) and (2:1) type acid:amine complex was proposed, whereas only (1:1) type was with (TOA + kerosene). Extraction equilibrium complexation constant for (1:1) acid:amine complex were evaluated to 133.90 m 3 •kmol −1 and 5.51 m 3 •kmol −1 for (TOA + decanol) and (TOA + kerosene) extraction system, respectively. Effect of temperature (303 K to 343 K) on the extraction was also visualized, wherein extraction decreases on increasing temperature. Enthalpy change (ΔH) for the extraction of pyruvic acid using (TOA + decanol) and (TOA + kerosene) are estimated to be −21.92 kJ•mol −1 and −10.57 kJ•mol −1 , respectively. Change in free energy (ΔG) and change in entropy (ΔS) was also computed. Up to 98 % pyruvic acid (0.05 kmol• m −3 ) could be recovered using tri-n-octylamine (0.343 kmol•m −3 ) in decanol. (TOA + decanol) is found to be a better extraction system than (TOA +kerosene) for separation of pyruvic acid. Results obtained could be utilized for design of extractor.

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Kinetics of the Extraction of Succinic Acid with Tri‐n‐octylamine in 1‐Octanol Solution

Cited by 24 publications

References 25 publications

Succinate production in Escherichia coli

Succinate production in Escherichia coli

Enhanced extraction of 3‐demethylated colchicine from fermentation broth of Bacillus megaterium: Optimization of process parameters by statistical experimental design

Reactive Extraction of Pyruvic Acid Using Tri-n-octylamine Diluted in Decanol/Kerosene: Equilibrium and Effect of Temperature

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