1965
DOI: 10.1172/jci105290
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Kinetics of triglyceride turnover of very low density lipoproteins of human plasma.

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Cited by 219 publications
(69 citation statements)
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“…In this study, multicompartmental analysis of VLDL-TG kinetics following injection of labeled glycerol was employed in an attempt to distinguish between these two mechanisms for hypertriglyceridemia and to determine which is predominant. Farquhar et al (20) introduced the use of radioactive glycerol as a precursor for investigation of VLDL-TG kinetics, and they have employed it in a series of studies on causation of hypertriglyceridemia (1,2,22,23). Their studies were carried out for relatively short periods in fasting patients; specific activities of VLDL-TG were usually estimated for 12 h after injection of [3H]glycerol.…”
Section: Discussionmentioning
confidence: 99%
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“…In this study, multicompartmental analysis of VLDL-TG kinetics following injection of labeled glycerol was employed in an attempt to distinguish between these two mechanisms for hypertriglyceridemia and to determine which is predominant. Farquhar et al (20) introduced the use of radioactive glycerol as a precursor for investigation of VLDL-TG kinetics, and they have employed it in a series of studies on causation of hypertriglyceridemia (1,2,22,23). Their studies were carried out for relatively short periods in fasting patients; specific activities of VLDL-TG were usually estimated for 12 h after injection of [3H]glycerol.…”
Section: Discussionmentioning
confidence: 99%
“…Using single-exponential analysis, Farquhar et al (1,2,20,22,23) have suggested that most instances of hypertriglyceridemia are due to increased influx of VLDL-TG. Specifically, they concluded that concentrations of VLDL-TG are roughly proportional to influx rates up to a relatively fixed point of saturation of TG removal mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…This was done according to a previously reported method (25,31), which is briefly summarized as follows: [3H]glycerol is injected intravenously and becomes incorporated into plasma VLDL-TG molecules. The specific activity decay curve of the endogenously labeled VLDL-TG is measured, and from this curve, the fractional loss rate of the labeled VLDL-TG is calculated.…”
Section: Methodsmentioning
confidence: 99%
“…Since the VLDL-TG concentration is in a steady state throughout the study, the VLDL-TG removal rate is equal to the VLDL-TG production rate (25,31).…”
Section: Methodsmentioning
confidence: 99%
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