Kinetik der Decarboxylierung von p‐Aminosalicylsäure

Abstract

3, 652 (1948).

EFFECT OF CHANGING pH UPON THE RATE AND MECHANISM OF DECARBOXYLATION OF SUBSTITUTED ANTHRANILIC ACIDS

“…[9] would become equivalent to eq. [5] which does not fit the data. Equation [lo] also requires an isotope effect since k* cannot be eliminated from the equation in this pH range.…”

“…Willi and Stocker (5) found that the rate reaches a inaximum a t the isoelectric point and concluded that the rate-controlling step involves the protonation of 9-aminosalicylate anion, A-, a t the 1-position of the aroinatic ring. I-Iolvever, they found that, although the rate decreases as the pH is decreased below the isoelectric point, it does not decrease as fast as does the calculated value of [H+][A-1.…”

“…The first possibility is the one suggested by Willi (4,5) and requires a rate expression of the form: or its kinetic equivalent. Substituting eq.…”

Identity of a Major Chromogen in p-Aminosalicylic Acid and Sodium p-Aminosalicylate Dosage Forms

“…59.1 mc./mmole)l, phosphorylribose-1-pyrophosphate2, nicotinamide monon~cleotide~, salicylic 1 Amersham Searle. 2 Mann Research Lab. …”

“…Decarboxylation of p-aminosalicylic acid into maminophenol and carbon dioxide was extensively studied (1)(2)(3)(4). It seems generally agreed that m-aminophenol did not have a significant role in the adverse reactions of p-aminosalicylic acid but that the chromogenic factors probably did'.…”