Kinin receptors mediating the effect of bradykinin on gastric acid secretion

A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa

“…It has been reported that acetylcholine increased pepsin and acid secretion when added to the luminal or serosal surface of isolated toad mucosae incubated under an O 2 pressure of 2,000 mm Hg (Gonzaga and Alzamora 1981). Similarly, data from our laboratory (Alzamora et al 1998) have shown that the vasodilatory peptide bradykinin increased acid secretion when added to both the luminal and serosal surfaces of frog gastric mucosae incubated under conditions similar to those used by Gonzaga and Alzamora (1981). The involvement of histamine in gastric secretion has long been described.…”

Bradykinin stimulates prostaglandin E2 production and cyclooxygenase activity in equine nonglandular and glandular gastric mucosa in vitro

“…Many of the actions of kinins are mediated via BKstimulated PGs (Regoli and Barabé 1980). In the stomach, BK has been implicated in both gastric acid stimulation and inhibition (Alzamora et al 1998;Lindström et al 2001) and has been shown to mediate protective effects on gastric mucosa. For example, Rydning et al (2004) demonstrated that bradykinin (B 2 ) receptor blockade inhibited degranulation of submucosal mast cells in rat stomach and attenuated local vasodilation both in response to acid back diffusion and after stimulation of sensory neurons with capsaicin.…”