KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?

Harihar, Sitaram; Welch, Danny R.

doi:10.1007/s10555-023-10090-6

Cited by 10 publications

(6 citation statements)

References 159 publications

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“…This evidence revealed that high KISS1R expression in Human Epidermal Growth Factor Receptor (HER) 2-negative carcinoma could show alternate pathway to stimulate the tumor cells proliferation upon low HER 2 expression. The recent study also reported that KISS1 can be a potential therapeutic target for treating metastasized cancers via the elimination of quiescent cells or by the long-term induction of dormancy in tumor cells [26]. The kisspeptins family is generated from proteolytic cleavage by KISS1 and could affect the metastatic ability of ovarian cancer cells.…”

Section: Discussionmentioning

confidence: 99%

CDCA2 promotes breast cancer progression by downregulating KISS1 expression

2024

EJGO

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Breast cancer is a females' prevalent malignancy, resulting in higher mortality rates than other cancers. Therefore, exploring effective therapeutic targets and diagnostic biomarkers is critical for improving drugs' curative effect in treating breast cancer patients. The MDA-MB-231 and Michigan Cancer Foundation-7 (MCF-7) cells were transfected by pc-CDCA2, Small interfering RNA Negative Control (siNC), siCDCA2, and pc-KISS1 to investigate the effects of cell division cycle associated 2 (CDCA2) and kisspeptin 1 (KISS1) protein on breast cancer cell's viability, migration and invasion. Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) was used to examine the CDCA2 mRNA expression. Impact of CDCA2 and KISS1 on invasion ability, motility and viability of breast cancer cells were detected via colony-forming unit, Cell Counting Kit-8 (CCK-8) and transwell assay. The Annexin V-Fluorescein Isothiocyanate (annexin V-FITC) staining was employed to determine the cellular apoptosis ratio based on flow cytometry. Findings indicated that CDCA2 expression got increased in breast cancer tissues, which greatly enhanced the cell proliferation, migration and invasion ability. Moreover, the regulation of CDCA2 may suppress the activation of KISS1 in breast cancer cells. In summary, the findings depicted that in breast cancer cells, the CDCA2 expression was enhanced to promote cells motility, invasiveness and viability through inhibition of KISS1 expression. Therefore, targeted gene therapy to suppress the expression levels of CDCA2 and upregulation of the KISS1 have the potential to be promising therapeutic strategies for treating breast cancer metastasis.

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Section: Discussionmentioning

confidence: 99%

CDCA2 promotes breast cancer progression by downregulating KISS1 expression

2024

EJGO

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“…Until the present day, a wide range of NPs, including metallic NPs, polymeric NPs, semiconductor NPs, nanorods, ceramic NPs, lipid NPs, and dendrimers, have been studied and used as drug delivery applications for natural agents, including phytochemicals, in preclinical or clinical settings (Mondal et al, 2022;Spyratou et al, 2017;Zhang et al, 2017). Accumulating evidence underscores the ability of various nanoformulations of phytochemicals to enhance their aqueous solubility, bioavailability, and tumor cell specificity, as well as to limit multidrug resistance (Fakhri et al, 2023;Ghanbari-Movahed et al, 2022;Kashyap et al, 2021;Lagoa et al, 2020).…”

Section: Anticancer Activity Of Capsaicin-loaded Npsmentioning

confidence: 99%

Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression

Mondal,

Banerjee,

Terang

et al. 2024

Phytotherapy Research

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Cancer profoundly influences morbidity and fatality rates worldwide. Patients often have dismal prognoses despite recent improvements in cancer therapy regimens. However, potent biomolecules derived from natural sources, including medicinal and dietary plants, contain biological and pharmacological properties to prevent and treat various human malignancies. Capsaicin is a bioactive phytocompound present in red hot chili peppers. Capsaicin has demonstrated many biological effects, including antioxidant, anti‐inflammatory, antimicrobial, and anticarcinogenic capabilities. This review highlights the cellular and molecular pathways through which capsaicin exhibits antineoplastic activities. Our work also depicts the synergistic anticancer properties of capsaicin in conjunction with other natural bioactive components and approved anticancer drugs. Capsaicin inhibits proliferation in various cancerous cells, and its antineoplastic actions in numerous in vitro and in vivo carcinoma models impact oncogenesis, tumor‐promoting and suppressor genes, and associated signaling pathways. Capsaicin alone or combined with other phytocompounds or approved antineoplastic drugs triggers cell cycle progression arrest, generating reactive oxygen species and disrupting mitochondrial membrane integrity, ultimately stimulating caspases and promoting death. Furthermore, capsaicin alone or in combination can promote apoptosis in carcinoma cells by enhancing the p53 and c‐Myc gene expressions. In conclusion, capsaicin alone or in combination can have enormous potential for cancer prevention and intervention, but further high‐quality studies are needed to firmly establish the clinical efficacy of this phytocompound.

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“…Metastasis suppressor inhibits metastasis by keeping the disseminated tumor cells in a state of dormancy. 40 RECK is a membrane-anchored protein regulator, which is often downregulated in several types of cancers. As described by Yoko et al , enforced expression of RECK in tumor cells by a potent RECK-inducer, DSK638, inhibits metastasis.…”

Section: Therapeutic Approaches For Tumor Metastasismentioning

confidence: 99%