Kisspeptins, Estrogens and Male Fertility

Chianese, Rosanna; Cobellis, Gilda; Chioccarelli, Teresa; Ciaramella, Vincenza; Migliaccio, Marina; Fasano, Silvia; Pierantoni, Riccardo; Meccariello, Rosaria

doi:10.2174/0929867323666160902155434

Cited by 51 publications

(37 citation statements)

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“…Mammalian spermatogenesis is a complex and finely regulated progression of germ cells with morphological distinguishable characteristics [255][256][257]. Hence, the idea to systematically identify the complicate transcriptome of each cell type.…”

Section: Circrnas: From Testis To Embryomentioning

confidence: 99%

Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality

Chioccarelli

Pierantoni

Manfrevola

et al. 2020

JCM

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Spermatozoa (SPZ) are motile cells, characterized by a cargo of epigenetic information including histone post-translational modifications (histone PTMs) and non-coding RNAs. Specific histone PTMs are present in developing germ cells, with a key role in spermatogenic events such as self-renewal and commitment of spermatogonia (SPG), meiotic recombination, nuclear condensation in spermatids (SPT). Nuclear condensation is related to chromatin remodeling events and requires a massive histone-to-protamine exchange. After this event a small percentage of chromatin is condensed by histones and SPZ contain nucleoprotamines and a small fraction of nucleohistone chromatin carrying a landascape of histone PTMs. Circular RNAs (circRNAs), a new class of non-coding RNAs, characterized by a nonlinear back-spliced junction, able to play as microRNA (miRNA) sponges, protein scaffolds and translation templates, have been recently characterized in both human and mouse SPZ. Since their abundance in eukaryote tissues, it is challenging to deepen their biological function, especially in the field of reproduction. Here we review the critical role of histone PTMs in male germ cells and the profile of circRNAs in mouse and human SPZ. Furthermore, we discuss their suggested role as novel epigenetic biomarkers to assess sperm quality and improve artificial insemination procedure.

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Section: Circrnas: From Testis To Embryomentioning

confidence: 99%

Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality

Chioccarelli

Pierantoni

Manfrevola

et al. 2020

JCM

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“…Furthermore, re-expression of KISS1R in GnRH neurons is insufficient to normalise testicular function, suggesting a potential direct role of KISS1/KISS1R in testis physiology [15]. Studies in primates [16][17][18], rodents [19][20][21], amphibians [22][23][24] and fish [25,26] have observed potential regulatory roles of kisspeptin in germ cell progression, modulation of sperm function and testicular steroidogenesis. In this review, we discuss evidence of local expression of KISS1/KISS1R system in the testes and its role in direct testicular functions.…”

Section: Introductionmentioning

confidence: 99%

Kisspeptin and Testicular Function—Is It Necessary?

Sharma

Thaventhiran

Minhas

et al. 2020

IJMS

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The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigating the distribution, regulation and effects of kisspeptin and its receptor (KISS1/KISS1R) within the testes of species studied to date. There is substantial evidence of localised KISS1/KISS1R expression and peptide distribution in the testes. However, variability is observed in the testicular cell types expressing KISS1/KISS1R. Evidence is presented for modulation of steroidogenesis and sperm function by kisspeptin signaling. However, the physiological importance of such effects, and whether these are paracrine or endocrine manifestations, remain unclear.

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“…Spermatogenesis is a complex biological process that requires the self-renewal and the commitment of diploid spermatogonia for proliferation, the meiosis of spermatocytes and the post-meiotic differentiation of haploid spermatids into mature spermatozoa. This process strongly depends on endocrine control through the hypothalamus-pituitary-gonad (HPG) axis and requires intratesticular autocrine and paracrine communications between germ and somatic cells 1 – 5 . Environment and diet influence spermatogenesis with known consequences on male fertility 6 .…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation

Chianese

Viggiano

Urbanek

et al. 2018

Sci Rep

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Spermatogenesis depends on endocrine, autocrine and paracrine communications along the hypothalamus-pituitary-gonad axis. Bisphenol A (BPA), an estrogen-mimic endocrine disrupting chemical, is an environmental contaminant used to manufacture polycarbonate plastics and epoxy resins with toxic effects for male reproduction. Here we investigated whether the chronic exposure to low BPA doses affects spermatogenesis through the modulation of SIRT1, a NAD+-dependent deacetylase involved in the progression of spermatogenesis, with outcomes on apoptosis, oxidative stress, metabolism and energy homeostasis. BPA exposure via placenta first, and lactation and drinking water later, affected the body weight gain in male offspring at 45 postnatal days and the first round of spermatogenesis, with impairment of blood testis barrier, reactive oxygen species production, DNA damage and decreased expression of SIRT1. The analysis of SIRT1 downstream molecular pathways revealed the increase of acetyl-p53Lys370, γH2AX foci, the decrease of oxidative stress defenses and the higher apoptotic rate in the testis of treated animals, with partial rescue at sex maturation. In conclusion, SIRT1 pathways disruption after BPA exposure can have serious consequences on the first round of spermatogenesis.

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Kisspeptins, Estrogens and Male Fertility

Abstract: This review summarizes the upcoming data from experimental models and humans concerning the testicular activity of kisspeptins and estrogens to preserve male fertility. Mutual enhancement of kisspeptin and estradiol signalling for the progression of spermatogenesis has also been discussed.

Cited by 51 publications

References 0 publications

Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality

Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality

Kisspeptin and Testicular Function—Is It Necessary?

Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation

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