Kiwifruit extract enhances markers of innate and acquired immunity in a murine model

Qin, Shu; Silva, Ushani Mendis De; Chen, Song; Peng, Wenduo; Ahmed, Munawar; Lu, Guangjin; Yin, Yinjia; Liu, Aihua; Drummond, Lynley

doi:10.1080/09540100802117198

Cited by 22 publications

(13 citation statements)

References 36 publications

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“…Similar results were found for the aqueous green KFE to aqueous gold KFE, with decreased expression levels across sixteen gene sets related to the adaptive immune response and T-cell activation within colon samples from C57BL/6J, but not Il10 − / − , mice fed the KFE-supplemented diet. Other mouse studies have demonstrated that gold and green kiwifruit enhance the adaptive immune response to vaccination in otherwise healthy mice, including increased antigen-specific T-cell activation and Ig production ( 13 , 14 ) . A pilot human study investigating the effects of an aqueous extract of gold kiwifruit on ex vivo blood samples has found that incubation of blood cells with the KFE enhanced T-cell activation, phagocytosis, oxidative burst and natural killer cell activity ( 57 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Kiwifruit, the fruit of the Actinidia genus, contain a number of nutritionally important compounds, including vitamin C, folate, K, Mg and fibre ( 4 , 5 ) , as well as many plant secondary compounds such as carotenoids, polyphenols and terpenoids ( 6 – 8 ) . Several health benefits have been demonstrated for kiwifruit, including protection against carcinogenesis ( 9 ) , protection against oxidative stress and DNA damage ( 10 – 12 ) , enhanced adaptive immune response ( 13 , 14 ) and improved laxity ( 15 , 16 ) . In addition, extracts from gold kiwifruit ( Actinidia chinensis ‘Hort16A’) and green kiwifruit ( A. deliciosa ‘Hayward’) have been reported to suppress Toll-like receptor (TLR) signalling by innate immune cells in vitro , reducing the secretion of pro-inflammatory mediators such as NO or cytokines after cellular activation by bacterial antigens ( 12 , 17 – 19 ) .…”

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confidence: 99%

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Effects of kiwifruit extracts on colonic gene and protein expression levels in IL-10 gene-deficient mice

et al. 2011

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Inflammatory bowel disease (IBD) is a collective term for conditions characterised by chronic inflammation of the gastrointestinal tract involving an inappropriate immune response to commensal micro-organisms in a genetically susceptible host. Previously, aqueous and ethyl acetate extracts of gold kiwifruit (Actinidia chinensis) or green kiwifruit (A. deliciosa) have demonstrated anti-inflammatory activity using in vitro models of IBD. The present study examined whether these kiwifruit extracts (KFE) had immune-modulating effects in vivo against inflammatory processes that are known to be increased in patients with IBD. KFE were used as a dietary intervention in IL-10-genedeficient (Il10 2/2 ) mice (an in vivo model of IBD) and the C57BL/6J background strain in a 3 £ 2 factorial design. While all Il10 2/2 mice developed significant colonic inflammation compared with C57BL/6J mice, this was not affected by the inclusion of KFE in the diet. These findings are in direct contrast to our previous study where KFE reduced inflammatory signalling in primary cells isolated from Il10 2/2 and C57BL/6J mice. Whole-genome gene and protein expression level profiling indicated that KFE influenced immune signalling pathways and metabolic processes within the colonic tissue; however, the effects were subtle. In particular, expression levels across gene sets related to adaptive immune pathways were significantly reduced using three of the four KFE in C57BL/6J mice. The present study highlights the importance of investigating food components identified by cell-based assays with appropriate in vivo models before making dietary recommendations, as a food that looks promising in vitro may not be effective in vivo.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Effects of kiwifruit extracts on colonic gene and protein expression levels in IL-10 gene-deficient mice

et al. 2011

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“…Consumption of the aqueous extracts of whole fresh fruit of Hort16Aat 375 mg/kg for 12 days enhanced both innate and acquired immunity in cholera vaccine and tetanus/diphtheria vaccine models in Balb/c mice, showing a beneficial effect on healthy (Shu et al, 2008). The homopolysaccharide derivatived by O-sulfation from the roots of A. chinensis at concentration of 10 and 50 μg/ml activated phagocytic activity and increased NO production of RAW 264.7 macrophages, and the activity of sulfated polysaccharides is strongly related to the degree of the sulfation (Niu et al, 2016), and treatment with 50-300 μg/ml water-soluble polysaccharides dose-dependently stimulated NO production and phagocytic activity of RAW 264.7macrophages (Zhang et al, 2015).…”

Section: Chemical Compositionmentioning

confidence: 99%

Actinidia chinensis Planch.: A Review of Chemistry and Pharmacology

Fang

Chen

et al. 2019

Front. Pharmacol.

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Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or additive in food products and as folk medicine in China. It is a good source of triterpenoids, polyphenols, vitamin C, carbohydrate, amino acid, and minerals. These constituents render the A. chinensis with a wide range of pharmacological properties including antitumor, antioxidant, anti-inflammatory, immunoregulatory, hypolipemic, antidiabetic, and cardiovascular protective activities, suggesting that it may possibly be value in the prevention and treatment of pathologies associated to cancer, oxidative stress, and aging. This minireview provides a brief knowledge about the recent advances in chemistry, biological activities, utilization, and storage of Chinese kiwifruit. Future research directions on how to better use of this crop are suggested.

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“…Further, the observed antiinflammatory effect of the extracts in vitro was absent in an in vivo mouse model for inflammatory bowel disease, where only mild changes in adaptive immune signaling were observed (Edmunds et al, 2012). In another study involving mice, kiwifruit extracts significantly enhanced specific intestinal mucosal responses to vaccines (Shu et al, 2008).…”

Section: Modulation Of Inflammationmentioning

confidence: 97%

Putative mechanisms of kiwifruit on maintenance of normal gastrointestinal function

Bayer

Gearry

Drummond³

2017

Critical Reviews in Food Science and Nutrition

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Kiwifruit are recognized as providing relief from constipation and symptoms of constipation-predominant irritable bowel syndrome (IBS-C). However, the underlying mechanisms, specifically in regards to gastrointestinal transit time and motility, are still not completely understood. This review provides an overview on the physiological and pathophysiological processes underlying constipation and IBS-C, the composition of kiwifruit, and recent advances in the research of kiwifruit and abdominal comfort. Additionally, gaps in the research are highlighted and scientific studies of other foods with known effects on the gastrointestinal tract are consulted to find likely mechanisms of action. While the effects of kiwifruit fiber are well documented, observed increases in gastrointestinal motility caused by kiwifruit are not fully characterized. There are a number of identified mechanism that may be activated by kiwifruit compounds, such as the induction of motility via protease-activated signaling, modulation of microflora, changes in colonic methane status, bile flux, or mediation of inflammatory processes.

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Kiwifruit extract enhances markers of innate and acquired immunity in a murine model

Cited by 22 publications

References 36 publications

Effects of kiwifruit extracts on colonic gene and protein expression levels in IL-10 gene-deficient mice

Effects of kiwifruit extracts on colonic gene and protein expression levels in IL-10 gene-deficient mice

Actinidia chinensis Planch.: A Review of Chemistry and Pharmacology

Putative mechanisms of kiwifruit on maintenance of normal gastrointestinal function

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