KL probes for robotic-based cellular nano surgery

Lai, King Wai Chiu; Kwong, C.C.H.; Li, Wen J.

doi:10.1109/nano.2003.1231738

Cited by 17 publications

(3 citation statements)

References 6 publications

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“…Recently, research work has been performed to determine the forces involved in the cell injection. Research on bonding a microinjection pipette on the tip of a polyvinylidene fluoride (PVDF) film force sensor to detect the injection forces in fish egg biomanipulation was performed in [7]- [9]. A microelectromechanical system (MEMS)-based two-axis cellular force sensor was developed in [10] to investigate the mechanical properties of mouse oocyte zona pellucida.…”

Section: Introductionmentioning

confidence: 99%

Visual-Based Impedance Control of Out-of-Plane Cell Injection Systems

Huang

Sun

Mills

et al. 2009

IEEE Trans. Automat. Sci. Eng.

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Section: Introductionmentioning

confidence: 99%

Visual-Based Impedance Control of Out-of-Plane Cell Injection Systems

Huang

Sun

Mills

et al. 2009

IEEE Trans. Automat. Sci. Eng.

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“…For a detailed description of the KL etching process, [10] can be referenced. A KL probe fabricated using the KL process is compared with a Turner's probe and an AFM tip as shown in Figure 3.…”

Section: Nanometric Probesmentioning

confidence: 99%

Novel micro gripping, probing, and sensing devices for single-cell surgery

Xi²

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Several novel devices under development in our laboratories to ultimately realize a micro robotic system for single cell nano-scale probing, injection, imaging and surgery is described in this paper. Thus far, we have 1) developed MEMS polymer grippers that can be actuated under water with very large deflection and are capable of gripping 500um embryonic cells in water with ~2V input; 2) developed a probe-etching technique to controllably shape fiber probes into various tip geometries, i.e., fibers with initial diameter of 125um were sharpened into tips with angles ranging from <2.7 -9.7 o and with nano-scale tip diameters of <1um; 3) developed a novel PVDF force sensing system with resolution in the sub-uN range for applications in bio-manipulation, bio-injection, and potentially single cell surgery. Details of these technologies are discussed in this paper.

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“…A nano probe fabricated using the technique developed by our group in [12] is fixed on another manipulator and moves in z direction, which is used to transfer the solution to the microelectrodes. In order to check the precision and quality of solution spots on the chip substrate, a video microscope is implemented to observe the position of the microelectrodes on the chip.…”

Section: A System Architecturementioning

confidence: 99%

Towards Batch Fabrication of Carbon Nanotube Sensors by Combining Microinjection and Dielectrophoretic Manipulation

Lai

Fung

et al.

2004 IEEE International Conference on Robotics and Biomimetics

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-We present the preliminary design and test results of a novel automated Carbon Nanotube (CNT) microinjection system for batch fabrication of a bulk multi-walled carbon nanotubes (MWNT) based sensors. This project will eventually develop an automated system to rapidly and precisely execute the AC electrophoretic manipulation of MWNT bundles on substrates that are used to fabricate nano-sensors. We have already shown that, using dielectrophoretic manipulation, CNTs were successfully and repeatably manipulated between microfabricated electrodes. The CNT devices were demonstrated to potentially serve as novel thermal sensors with low power consumption (~ W) and electronic circuit response of about 100 kHz in constant current mode operation. Besides, preliminary microinjection experiments were conducted which demonstrated the possibility of the automated microinjection of solution with spot size of ~200 m. Based on these experimental evidences, a feasible batch fabrication method for functional CNT sensors by using an automated injection system is under development. The system will ultimately reduce fabrication accuracy and time of nano sensing devices and potentially enable fully automated assembly of CNT and other nano-wire based devices.

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KL probes for robotic-based cellular nano surgery

Cited by 17 publications

References 6 publications

Visual-Based Impedance Control of Out-of-Plane Cell Injection Systems

Visual-Based Impedance Control of Out-of-Plane Cell Injection Systems

Novel micro gripping, probing, and sensing devices for single-cell surgery

Towards Batch Fabrication of Carbon Nanotube Sensors by Combining Microinjection and Dielectrophoretic Manipulation

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