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Павлов, О. В.; Сельков, С. А.; Lalayan, D. V.; Аржанова, О. Н.

doi:10.1023/a:1024621100429

Cited by 2 publications

(2 citation statements)

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“…Similarly as in our previous study [1], we observed a significant (7.5 times) increase in IL-6 production in early spontaneous abortion. However, we previously failed to detect differences in the secretion of IL-1β and TNF-α, while present findings indicate a significant decrease in the production of these proinflammatory cytokines (and antiinflammatory IL-10) in miscarriage.…”

Section: Resultssupporting

confidence: 91%

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Spontaneous and LPS-induced secretion of cytokines by villous chorion tissue

2006

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Secretion of IL-1alpha, IL-1beta, IL-6, IL-10, and TNF-alpha cytokines by villous chorion cultures (7-14 weeks) during normal pregnancy and in spontaneous abortions was studied. Secretion of IL-1alpha and IL-6 increased 4.5 and 7.3 times in miscarriages, while secretion of IL-1beta, IL-10, and TNF-alpha decreased. LPS stimulated the production of IL-1alpha and IL-6 in samples obtained during surgical abortion. LPS stimulated IL-1alpha and TNF-alpha secretion in miscarriages, while the level of IL-6 production decreased significantly. It is hypothesized that increased production of IL-1alpha and IL-6 and attenuation of the antiinflammatory effect of IL-10 play an important role in the pathogenesis of miscarriages at early stages of gestation. The results suggest that cytokine regulation of the fetus rejection is different at early and late stages of gestation.

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Section: Resultssupporting

confidence: 91%

“…We previously studied secretion of proinflammatory cytokines in forming placental tissues in normal and pathological gestation [1]. Here we more precisely evaluated some facts obtained previously for IL-1β, IL-6, TNF-α, and investigated a wider spectrum of cytokines, including antiinflammatory cytokine IL-10 and the α-form of IL-1.…”

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confidence: 98%

Spontaneous and LPS-induced secretion of cytokines by villous chorion tissue

2006

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Methamphetamine: Effects on the brain, gut and immune system

Prakash

Tangalakis

Antonipillai

et al. 2017

Pharmacological Research

159

103

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Methamphetamine (METH) is a powerful central nervous system stimulant which elevates mood, alertness, energy levels and concentration in the short-term. However, chronic use and/or at higher doses METH use often results in psychosis, depression, delusions and violent behavior. METH was formerly used to treat conditions such as obesity and attention deficit hyperactivity disorder, but now is primarily used recreationally. Its addictive nature has led to METH abuse becoming a global problem. At a cellular level, METH exerts a myriad of effects on the central and peripheral nervous systems, immune system and the gastrointestinal system. Here we present how these effects might be linked and their potential contribution to the pathogenesis of neuropsychiatric disorders. In the long term, this pathway could be targeted therapeutically to protect people from the ill effects of METH use. This model of METH use may also provide insight into how gut, nervous and immune systems might break down in other conditions that may also benefit from therapeutic intervention.

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Cited by 2 publications

References 6 publications

Spontaneous and LPS-induced secretion of cytokines by villous chorion tissue

Spontaneous and LPS-induced secretion of cytokines by villous chorion tissue

Methamphetamine: Effects on the brain, gut and immune system

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