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Beketov, V. I.; Voronina, R. D.; Филатова, Д. Г.; Зоров, Н. Б.

doi:10.1023/a:1026658802618

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…159 A similar increase in sensitivity was observed in the determination of amino acids, when in the reaction with OPA the thiol 2-ME was replaced not only by SO 3 2but also by CN -. 160 In the latter reaction, a derivative of 1-cyanoisoindole was formed. Such compounds were isolated 161,162 under synthetic conditions in a reaction of OPA with CNions and primary amines.…”

Section: Reagents Prepared By Reaction Of Orthophthalaldehyde With Nu...mentioning

confidence: 99%

Reactions of Orthophthalaldehyde with Nucleophiles

Zuman

2004

Chem. Rev.

127

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Contents 1. Introduction 3217 2. Addition of a Single Nucleophile to OPA 3218 2.1. Addition of Water and Hydroxide Ions 3218 2.2. Addition of Alcohols 3219 2.3. Addition of Ammonia and Primary Amines 3219 2.4. Reactions with Hydrazine 3219 2.5. Reactions with Amino Acids 3220 2.6. Reactions with Amides, Urea, and Thiourea 3221 2.7. Reactions with Carbanions 3221 2.8. Reactions with Thiols and Other Sulfur Compounds3222 3. Reactions in the Presence of Two Nucleophiles 3223 3.1. Reagents 3224 3.1.1. Role of the Carbonyl Compound 3224 3.1.2. Stability of the Mixed Reagent 3224 3.1.3. Structure of the Thiol 3224 3.1.4. Structures of Amino Acids and Amines 3225 3.2. Sequence of Addition 3225 3.3. Reaction Medium 3225 3.4. Kinetics of the Formation of the Primary Product 3227 3.5. Consecutive Reactions of the Isoindole DerivativesStability of the Product of the Analytical Reaction 3228 3.6. Proposed Reaction Schemes 3232 3.6.1. Scheme Proposed by Simmons and Johnson 3232 3.6.2. Scheme Proposed by Wong, Sternson, and Schowen 3232 3.6.3. Scheme Proposed by Sternson, Stobaugh, and Repta 3233 3.6.4. Scheme Proposed by Gladilovich, Kartsova, and Zakharova 3233 3.6.5. Scheme of the Degradation of the Derivative of 2-Mercaptoethanol 3233 3.6.6.Scheme for Autoxidation of the Isoindole 3234 3.6.7. Conclusions Regarding Reaction Scheme 3234 3.7. Techniques Used 3234 3.8. Other Uses of the Reagent Formed in Reaction of OPA with Thiols 3235 3.9. Reagents Prepared by Reaction of Orthophthalaldehyde with Nucleophiles Other than Thiols 3235 3.10. Some Biochemical Applications 3236 4. Conclusions 3237 5. Acknowledgment 3237 6. References 3237

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Section: Reagents Prepared By Reaction Of Orthophthalaldehyde With Nu...mentioning

confidence: 99%

Reactions of Orthophthalaldehyde with Nucleophiles

Zuman

2004

Chem. Rev.

127

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A simple and rapid high‐performance liquid chromatography method for determination of alendronate sodium in beagle dog plasma with application to preclinical pharmacokinetic study

Meng

Zheng

2009

Biomedical Chromatography

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A simple and rapid high performance liquid chromatographic (HPLC) method for quantifying alendronate in beagle dog plasma was developed, validated and applied to a pharmacokinetic study. The sample preparation involved coprecipitation with CaCl(2) and derivatization with o-phthalaldehyde. Chromatographic separation was achieved on a Diamonsil C(18 )(250 x 4.6 mm, 5 microm) using acetonitrile-0.4% EDTA-Na(2) (16:84, v/v) containing 0.034% of NaOH as mobile phase. The fluorimetric detector was operated at 339 nm (excitation) and 447 nm (emission). The linearity over the concentration range of 5.00-600 ng/mL for alendronate was obtained and the lower limit of quantification was 5.00 ng/mL. For each level of quality control samples, inter-day and intra-day precisions were less than 8.52 and 7.42% and accuracies were less than 9.07%. The assay was applied to the analysis of samples from a pharmacokinetic study. Following the oral administration of 70 mg alendronate sodium to beagle dogs, the maximum plasma concentration (C(max)) and elimination half-life were 152 +/- 27.3 and 1.75 +/- 0.267 h, respectively. The method was demonstrated to be highly feasible and reproducible for pharmacokinetic studies.

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Chemiluminescence determination of 20 amino acids and the mechanism study

Liu

2010

Chinese Chemical Letters

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Cited by 5 publications

References 6 publications

Reactions of Orthophthalaldehyde with Nucleophiles

Reactions of Orthophthalaldehyde with Nucleophiles

A simple and rapid high‐performance liquid chromatography method for determination of alendronate sodium in beagle dog plasma with application to preclinical pharmacokinetic study

Chemiluminescence determination of 20 amino acids and the mechanism study

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