Klassifikation der Bandscheibendegeneration des Hundes in der nativen Computertomographie und der Hochfeld-Magnetresonanztomographie

Harder, Lisa; Ludwig, Davina C; Galindo-Zamora, Vladimir; Wefstaedt, Patrick; Nolte, Ingo

doi:10.15654/tpk-140228

Cited by 4 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reviewed MRI records were transverse T2 weighted Fast Field Echo images (Time to echo 120 ms, repetition time 4.5–12.2 s, slice thickness 1.8–5 mm) obtained in a 3.0 T Highfield MRI 3 . Analysis of IVD degeneration in non-contrast CT (using a self-developed classification system) and MRI (using the Pfirrmann scoring system) had already been carried out as part of another study using identical non-contrast MRI and CT data sets from the same dogs [ 11 ]. The results of these evaluations were used for comparison with the colour-coded analysis carried out in the study described here.…”

Section: Methodsmentioning

confidence: 99%

“…Three observers with different degrees of experience in evaluating computed tomographic images (observer 1, 2 years of experience (LH); observer 2, 5 years of experience (VGZ); observer 3, 24 years of experience (IN)) evaluated all images on standard computer screens using ImageJ. A self-developed scoring system was used to evaluate IVD degeneration (Table 1 ) [ 11 ]. The observers were familiarised with the scoring system, being given several examples of the various grades of IVD degeneration in colour-coded images (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, CT imaging of the IVD and displaced disc material have been reported [ 8 – 10 ]. Recently, the authors of this study suggested a grading system for evaluating IVD degeneration in CT [ 11 ]. In comparison to T2 weighted magnetic resonance imaging, initial degenerative changes in IVD morphology were not seen in non-contrast CT images [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the authors of this study suggested a grading system for evaluating IVD degeneration in CT [ 11 ]. In comparison to T2 weighted magnetic resonance imaging, initial degenerative changes in IVD morphology were not seen in non-contrast CT images [ 11 ]. CT images consist of Hounsfield Units, which are depending on the attenuation of the exposed structure and tissue [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of canine intervertebral disc degeneration in colour-coded computed tomography

et al. 2015

View full text Add to dashboard Cite

BackgroundCanine intervertebral disc degeneration can lead to intervertebral disc disease. Mild degenerative changes in the structure of the canine intervertebral disc can be identified in magnetic resonance images, whereas these changes are not visible in computed tomographic images. Therefore, one aim of this study was to detect whether colour-coded computed tomography enhances the visibility of mild degenerative changes in the canine disc structure compared to non-contrast computed tomography. Furthermore, the study aimed to detect if intervertebral disc degeneration could be classified with a higher reliability in colour-coded images than in non-contrast images.ResultsComputed tomographic image studies of 144 canine intervertebral discs were coloured using three different lookup tables. Canine intervertebral disc degeneration was evaluated by three observers using a 5-grade classification system and compared to the evaluation of non-contrast CT and MRI images. A moderate to almost perfect intraobserver and a moderate to substantial interobserver agreement were found depending on the used colour code. On comparing non-contrast and colour-coded CT significant differences were found by one observer only. Significant differences in evaluation were found in grading intervertebral disc degeneration in MRI and colour-coded CT.ConclusionsIntervertebral disc degeneration could not be classified with a higher reliability on colour-coded images compared to non-contrast images. Furthermore, colour-coded CT did not enhance the visibility of mild degenerative changes in disc structure compared to non-contrast CT.However, the better intraobserver agreement and the subjective impression of the observers highlighted that the usage of colour encoded CT data sets with a wide range of tonal values of few primary and secondary colours may facilitate evaluation.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of canine intervertebral disc degeneration in colour-coded computed tomography

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Bei einem akuten Bandscheiben -Tab. 1 Klassifikationsschema zur Beurteilung der Bandscheibendegeneration des Hundes in der Computertomographie (33) Table 1 Grading system for the classification of intervertebral disc degeneration on computed tomographic images (33). Ist das dislozierte Bandscheibenmaterial nicht direkt identifizierbar, lassen sich weitere Veränderungen im CT-Bild heranziehen, die für einen Bandscheibenvorfall sprechen.…”

Section: Pathologische Befundeunclassified

Bandscheibenveränderungen des Hundes in der bildgebenden Diagnostik

Harder

2016

Tierarztl Prax Ausg K

View full text Add to dashboard Cite

Intervertebral disc degeneration can cause intervertebral disc herniation. Diagnostic imaging, including radiography, computed tomography and magnetic resonance imaging, is the most important tool in diagnosis. Firstly, an overview of macroscopic and biochemical physiology and pathology of the intervertebral disc will be given. Subsequently, the physics of diagnostic imaging and the appearance of intervertebral disc degeneration and displacement in several imaging methods are described.

show abstract

Inflammatory profiles in canine intervertebral disc degeneration

et al. 2016

View full text Add to dashboard Cite

BackgroundIntervertebral disc (IVD) disease is a common spinal disorder in dogs and degeneration and inflammation are significant components of the pathological cascade. Only limited studies have studied the cytokine and chemokine profiles in IVD degeneration in dogs, and mainly focused on gene expression. A better understanding is needed in order to develop biological therapies that address both pain and degeneration in IVD disease. Therefore, in this study, we determined the levels of prostaglandin E2 (PGE2), cytokines, chemokines, and matrix components in IVDs from chondrodystrophic (CD) and non-chondrodystrophic (NCD) dogs with and without clinical signs of IVD disease, and correlated these to degeneration grade (according to Pfirrmann), or herniation type (according to Hansen). In addition, we investigated cyclooxygenase 2 (COX-2) expression and signs of inflammation in histological IVD samples of CD and NCD dogs.ResultsPGE2 levels were significantly higher in the nucleus pulposus (NP) of degenerated IVDs compared with non-degenerated IVDs, and in herniated IVDs from NCD dogs compared with non-herniated IVDs of NCD dogs. COX-2 expression in the NP and annulus fibrosus (AF), and proliferation of fibroblasts and numbers of macrophages in the AF significantly increased with increased degeneration grade. GAG content did not significantly change with degeneration grade or herniation type. Cytokines interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, immune protein (IP)-10, tumor necrosis factor (TNF)-α, and granulocyte macrophage colony-stimulating factor (GM-CSF) were not detectable in the samples. Chemokine (C-C) motif ligand (CCL)2 levels in the NP from extruded samples were significantly higher compared with the AF of these samples and the NP from protrusion samples.ConclusionsPGE2 levels and CCL2 levels in degenerated and herniated IVDs were significantly higher compared with non-degenerated and non-herniated IVDs. COX-2 expression in the NP and AF and reactive changes in the AF increased with advancing degeneration stages. Although macrophages invaded the AF as degeneration progressed, the production of inflammatory mediators seemed most pronounced in degenerated NP tissue. Future studies are needed to investigate if inhibition of PGE2 levels in degenerated IVDs provides effective analgesia and exerts a protective role in the process of IVD degeneration and the development of IVD disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-016-0635-6) contains supplementary material, which is available to authorized users.

show abstract

Klassifikation der Bandscheibendegeneration des Hundes in der nativen Computertomographie und der Hochfeld-Magnetresonanztomographie

Cited by 4 publications

References 34 publications

Evaluation of canine intervertebral disc degeneration in colour-coded computed tomography

Evaluation of canine intervertebral disc degeneration in colour-coded computed tomography

Bandscheibenveränderungen des Hundes in der bildgebenden Diagnostik

Inflammatory profiles in canine intervertebral disc degeneration

Contact Info

Product

Resources

About