Klebsiella bacteraemia: community versus nosocomial infection

Abstract

In the period 1988-1993, 241 patients had Klebsiella bacteraemia at our medical centre. The annual number of patients with positive blood cultures increased from 306 in 1988 to 622 in 1993, representing a 4.5-6% positivity rate of drawn cultures. After E. coli, Klebsiella was the leading cause of Gram-negative bacteraemia. During this period, the absolute number of Klebsiella bacteraemia increased from 25 in 1988 to 84 in 1993; this represents a true increase in Klebsiellaa bacteraemia, from 6-7% of positive cultures in the late 1980s to 12-13% in more recent years. There were 210 cases with K. pneumoniae and 31 with K. oxytoca. A representative sample of 80 records was retrieved and subdivided into two groups: community-acquired Klebsiella bacteraemia (CAKB) vs. hospital-acquired Klebsiella bacteraemia (HAKB). Urinary tract infection was the underlying source of 58% of CAKB vs 28% of HAKB (p < 0.01); pneumonia occurred significantly more often in HAKB (25%) than in CAKB (7%) (p < 0.01). In HAKB, as compared to CAKB, serious manifestations of illness were more common, e.g. shock (65% vs. 37%, p < 0.046) and respiratory failure (45% vs. 20%, p < 0.046). Overall mortality was 32%, 22% of patients with CAKB died vs. 42% of those with HAKB (p < 0.05). Multiple drug resistance was very common: only 57% of all Klebsiella strains were susceptible to gentamicin, 66% to ceftriaxone, 70% to ciprofloxacin, and 83% to amikacin. The susceptibility rates of Klebsiella spp isolated from patients with HAKB were significantly lower (p < 0.001). Sepsis due to multiple-drug-resistant Klebsiellaa has become frequent, carrying significant morbidity and mortality. Restriction of broad-spectrum antimicrobials in the hospital and the community as well as implementation of infection control measures are needed to contain this problem.

Evaluation of the Types of Bacteria in the Blood of HIV-1 Patients Attending ART Clinic at the FMC Owo, Nigeria and their Antibiogram Profile

“…Some of the bacterial species implicated in bloodstream infections are Klebsiella sp. and Escherichia coli [6]. This study therefore is to screen the blood of HIV-1 patients in the studied community for the types of bacterial pathogens present and to know the antibiogram profile of these microorganisms.…”

CD44 Deficiency Is Associated with Increased Bacterial Clearance but Enhanced Lung Inflammation During Gram-Negative Pneumonia

“…Klebsiella (K.) pneumoniae is a frequently isolated causative pathogen in lower respiratory tract infection. [1][2][3] The high incidence of pneumonia and the increasing resistance of respiratory pathogens to antimicrobial agents stress the importance of gaining more insight into the pathogenesis of this infection. 1,4 CD44 is a transmembrane adhesion molecule known to be involved in binding and metabolism of hyaluronan (HA).…”

Management of infection in systemic lupus erythematosus

“…Some studies showed that Klebsiella was one of the leading causes of Gram-negative bacteraemia in the general population [25]. SLE patients infected with Klebsiella were found to have lower probabilities of 14-day survival [26] in a study analysing the short-term survival of patients with SLE after bacteraemia episodes.…”