Klebsiella pneumoniae Urinary Tract Infections Associated with Long-term Catherterizaton and Spinal Cord Injuries

bint-e-Mas, Madahiah; Saba, Noor-us; Samad, Abdul; Qazilbash, Ali Abbas

doi:10.3923/jms.2002.227.229

Cited by 7 publications

(1 citation statement)

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“…(Manikandan and Amsath,2013). In this study high level of resistance was seen in Nitrofurantoin (89.5%) which is higher than the study of Masood that reported resistance of Klebsiella pneumoniae to Nitrofurantoin (67%) which was isolated from urine samples in Islamabad, Pakistan by (Masood et al, 2002). The Klebsiella pneumoniae isolates are generally susceptible to the tested antibiotics except Nitrofurantoin.…”

Section: Discussioncontrasting

confidence: 62%

Antimicrobial Resistant Pattern of Klebsiella pneumoniae Isolated from the Stool of Healthy Volunteers of Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State

Germany,

Bunu,

Adebola

2023

Preprint

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Background Klebsiella pneumoniae bacteria is a normal flora of the human intestinal tract where they do not cause disease in normal circumstances but can also act as a human opportunistic pathogenic infection when it proliferates in increased amounts, where it may cause a host of health complaints and symptoms ranging from mild to serious infections (pneumonia, septicemia, Urinary tract infections). The virulence factors like capsule, lipopolysaccharide, and type 1 or type 3 fimbriae are responsible for K. pneumoniae to form biofilm. Klebsiella pneumonia responsible for serious outbreaks of multi-drug resistant diseases may be due to uncontrolled usage of antibiotics. Method The samples were isolated and identified using standard microbiological methods. The isolates were screened for possible virulence traits using the Blood agar test and Congo-Red test. Antibiotic susceptibility screening was carried out for the isolates. Results In this study (25.3%) Klebsiella pneumoniae isolates were recovered from the 300 stool samples of the healthy student volunteers, of which 29(38.2%) were from males and 47(61.8%) from females. The 76 Klebsiella pneumoniae isolates screened are biofilm producers while none produced hemolysin. The antimicrobial susceptibility pattern for the 76 Klebsiella pneumoniae isolates in this study revealed (Co-trimoxazole 3.9%, Ciprofloxacin 11.8%, Cefotaxime 9.2%, Ceftazidime 6.6% and Gentamicin 9.2%, Imipenem 17.1% and Ertapenem 40.8% and Nitrofurantoin (89.5%). In this study (17.1%) Klebsiella pneumoniae isolates exhibited multi-drug resistance. Conclusion Drug resistance surveillance has revealed that asymptomatic carriers in the community are often colonized with resistant bacteria that subsequently lead to infections.

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Section: Discussioncontrasting

confidence: 62%

Antimicrobial Resistant Pattern of Klebsiella pneumoniae Isolated from the Stool of Healthy Volunteers of Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State

Germany,

Bunu,

Adebola

2023

Preprint

View full text Add to dashboard Cite

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Molecular characterization of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from King Abdulaziz Specialist Hospital at Taif City, Saudi Arabia

Lagha

Abdallah

ALKhammash

et al. 2021

Journal of Infection and Public Health

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Investigation of Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Klebsiella pneumoniae

Karimi

Zarei

Sedighi

et al. 2021

International Journal of Microbiology

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Aim. Klebsiella pneumoniae (K. pneumoniae) is an encapsulated Gram-negative bacterium that can lead to 14–20% of nosocomial infections. The ability of biofilm formation in this bacterium decreases the host immune response and antibiotic efficacy. This may impose a huge impact on patients and healthcare settings. This study aimed to evaluate the antibiotic resistance pattern and biofilm formation in K. pneumoniae strains isolated from two major Hamadan hospitals, west of Iran. Methods. A total of 83 K. pneumoniae strains were isolated from clinical samples of patients in different wards of Hamadan hospitals from September 2018 to March 2019. Determination of antimicrobial susceptibility was performed using the disk diffusion method. Biofilm formation was evaluated by the crystal violet method. Data were analyzed by the SPSS software and chi-square test. Results. The results showed that clinical samples included 18 urinary tract samples (22%), 6 wound samples (7%), 6 blood samples (7%), 17 tracheal tube aspiration samples (20%), 32 throat cultures (38%), 2 sputum samples (2.5%), and 2 abscess drain cultures (2.5%). High-level resistance to cefotaxime was detected in 92%, and all of isolates were susceptible to colistin. Biofilm formation was seen in 62 (75%) isolates. Strong biofilm formation was observed in 17 (20%) strains. A significant correlation was seen between biofilm formation and antibiotic resistance ( P value <0.05). Conclusion. Our findings emphasize the need for proper diagnosis, control, and treatment of infections caused by K. pneumoniae especially in respiratory tract infections due to the strong biofilm formation and high antibiotic resistance in these strains.

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Klebsiella pneumoniae Urinary Tract Infections Associated with Long-term Catherterizaton and Spinal Cord Injuries

Cited by 7 publications

References 0 publications

Antimicrobial Resistant Pattern of Klebsiella pneumoniae Isolated from the Stool of Healthy Volunteers of Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State

Antimicrobial Resistant Pattern of Klebsiella pneumoniae Isolated from the Stool of Healthy Volunteers of Niger Delta University, Wilberforce Island, Amassoma, Bayelsa State

Molecular characterization of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from King Abdulaziz Specialist Hospital at Taif City, Saudi Arabia

Investigation of Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Klebsiella pneumoniae

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