KLF5-trancripted miR-125b-5p is involved in enhancing the radio-sensitivity of breast cancer cells by targeting BRCA1

Gong, Ting; Jia, Bin; Gu, Liyan; Yu, Tao

doi:10.1007/s13273-021-00177-y

Cited by 3 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, KLFs also play a critical role in response to radiotherapy. KLF5 is an upstream transcription factor that promotes the expression of miR-125b-5p, which hinders cell proliferation and strengthens radio sensitivity in BC ( 222 ). In lung cancer, KLF11 overexpresses after radiotherapy, which induces apoptosis and inhibits cell proliferation by increasing intracellular reactive oxygen levels ( 147 ).…”

Section: Applications Of Klfs In Precision Medicinementioning

confidence: 99%

Krüppel-like factors in tumors: Key regulators and therapeutic avenues

Zhang

Yao

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with multiple essential functions in various cellular processes, including proliferation, migration, inflammation, and angiogenesis. The aberrant expression of KLFs is often found in tumor tissues and is essential for tumor development. At the molecular level, KLFs regulate multiple signaling pathways and mediate crosstalk among them. Some KLFs may also be molecular switches for specific biological signals, driving their transition from tumor suppressors to promoters. At the histological level, the abnormal expression of KLFs is closely associated with tumor cell stemness, proliferation, apoptosis, and alterations in the tumor microenvironment. Notably, the role of each KLF in tumors varies according to tumor type and different stages of tumor development rather than being invariant. In this review, we focus on the advances in the molecular biology of KLFs, particularly the regulations of several classical signaling pathways by these factors, and the critical role of KLFs in tumor development. We also highlight their strong potential as molecular targets in tumor therapy and suggest potential directions for clinical translational research.

show abstract

Section: Applications Of Klfs In Precision Medicinementioning

confidence: 99%

Krüppel-like factors in tumors: Key regulators and therapeutic avenues

Zhang

Yao

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…miR-146a-5p overexpression promoted the apoptosis and radiosensitivity of liver cancer cells [83], and its radiation targets NUCKS1, YAP1, and RNF4 were identified (Table 2). miR-125b-5p overexpression improved the radiosensitivity of breast cancer cells [84], and its radiation target TLK2 was identified (Table 2). miR-29a-3p enhanced the radiosensitivity of oral cancer cells [85], and its radiation targets CCND2 and MDM2 were identified (Table 2).…”

Section: Some Natural-product-regulated Mirnas Can Function As Radios...mentioning

confidence: 99%

Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis

Tang

Chuang

Shiau

et al. 2023

IJMS

View full text Add to dashboard Cite

Exosomes are cell-derived membranous structures primarily involved in the delivery of the payload to the recipient cells, and they play central roles in carcinogenesis and metastasis. Radiotherapy is a common cancer treatment that occasionally generates exosomal miRNA-associated modulation to regulate the therapeutic anticancer function and side effects. Combining radiotherapy and natural products may modulate the radioprotective and radiosensitizing responses of non-cancer and cancer cells, but there is a knowledge gap regarding the connection of this combined treatment with exosomal miRNAs and their downstream targets for radiation and exosome biogenesis. This review focuses on radioprotective natural products in terms of their impacts on exosomal miRNAs to target radiation-modulating and exosome biogenesis (secretion and assembly) genes. Several natural products have individually demonstrated radioprotective and miRNA-modulating effects. However, the impact of natural-product-modulated miRNAs on radiation response and exosome biogenesis remains unclear. In this review, by searching through PubMed/Google Scholar, available reports on potential functions that show radioprotection for non-cancer tissues and radiosensitization for cancer among these natural-product-modulated miRNAs were assessed. Next, by accessing the miRNA database (miRDB), the predicted targets of the radiation- and exosome biogenesis-modulating genes from the Gene Ontology database (MGI) were retrieved bioinformatically based on these miRNAs. Moreover, the target-centric analysis showed that several natural products share the same miRNAs and targets to regulate radiation response and exosome biogenesis. As a result, the miRNA–radiomodulation (radioprotection and radiosensitization)–exosome biogenesis axis in regard to natural-product-mediated radiotherapeutic effects is well organized. This review focuses on natural products and their regulating effects on miRNAs to assess the potential impacts of radiomodulation and exosome biogenesis for both the radiosensitization of cancer cells and the radioprotection of non-cancer cells.

show abstract

“…Meiotic recombination 11 (MRE11) is recruited at the DSB site by PARylation, and is involved in DNA end resection and HR selection [ 38 ]. The function of breast cancer type 1 (BRCA1) is regulated by PARylation [ 39 , 40 ]. BRCA1 is recruited by PARylation at the DSB site, and PARylated BRCA1 regulates DNA recombination [ 41 ].…”

Section: Role Of Parylation In Dna Damage Response and Repairmentioning

confidence: 99%

A Double-Edged Sword: The Two Faces of PARylation

Kang

Park

et al. 2022

IJMS

View full text Add to dashboard Cite

Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage. Originally, studies on PARylation were confined to PARP-1 activation in the DNA repair pathway. However, the interplay between PARylation and DNA repair suggests that PARylation is important for the efficiency and accuracy of DNA repair. PARylation has contradicting roles; however, recent evidence implicates its importance in inflammation, metabolism, and cell death. These differences might be dependent on specific cellular conditions or experimental models used, and suggest that PARylation may play two opposing roles in cellular homeostasis. Understanding the role of PARylation in cellular function is not only important for identifying novel therapeutic approaches; it is also essential for gaining insight into the mechanisms of unexplored diseases. In this review, we discuss recent reports on the role of PARylation in mediating diverse cellular functions and homeostasis, such as DNA repair, inflammation, metabolism, and cell death.

show abstract

KLF5-trancripted miR-125b-5p is involved in enhancing the radio-sensitivity of breast cancer cells by targeting BRCA1

Cited by 3 publications

References 37 publications

Krüppel-like factors in tumors: Key regulators and therapeutic avenues

Krüppel-like factors in tumors: Key regulators and therapeutic avenues

Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis

A Double-Edged Sword: The Two Faces of PARylation

Contact Info

Product

Resources

About